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MIDAZOLAM HCL (MIDAZOLAM HCL/PF)
- Conscious sedation
- General anesthesia adjunct
- Sedation in intubated patient
- Induce anterograde amnesia
- Local anesthesia adjunct
- Preoperative anxiety
- Midazolam Injection Solution
- Midazolam (pf) Injection Syringe
- Midazolam (pf) Injection Solution
- Midazolam (pf) Injection Cartridge
- By Indication
1 mg/mL injection solution
- Dosage information is not available
5 mg/mL injection solution
- Dosage information is not available
midazolam 1 mg/mL injection solution
- Dosage information is not available
midazolam 5 mg/mL injection solution
- Dosage information is not available
midazolam (PF) 2 mg/2 mL (1 mg/mL) injection syringe
- Dosage information is not available
midazolam (PF) 5 mg/mL injection syringe
- Dosage information is not available
1 mg/mL injection solution
- Dosage information is not available
5 mg/mL injection solution
- Dosage information is not available
midazolam (PF) 1 mg/mL injection solution
- Dosage information is not available
midazolam (PF) 5 mg/mL injection solution
- Dosage information is not available
midazolam (PF) 2 mg/2 mL (1 mg/mL) injection cartridge
- Dosage information is not available
midazolam (PF) 5 mg/mL injection cartridge
- Dosage information is not available
Sedation in intubated patient
- Infuse 20 mcg/kg/hour by continuous infusion route
- Infuse 100 mcg/kg/hour by continuous infusion route
- delavirdine
- Rescriptor
- sodium oxybate
- Xyrem
Contraindicated
- Calan
- Calan Sr
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- clozapine
- Clozaril
- conivaptan in 5 % dextrose
- Dehydrated Alcohol
- Dilacor Xr
- Dilt-xr
- diltiazem HCl
- ethanol (ethyl alcohol)
- ethyl alcohol-herbal drugs
- Fazaclo
- Lydia Pinkham Herbal
- Matzim La
- olanzapine
- olanzapine pamoate
- Tarka
- Taztia Xt
- Tiazac
- trandolapril-verapamil
- Vaprisol
- verapamil
- Verelan
- Verelan Pm
- Versacloz
- Zyprexa
- Zyprexa Relprevv
Severe
Moderate
- AA#9-carnit-dext-cocoa-hrb#128
- Acid Reducer (cimetidine)
- Acid Relief (cimetidine)
- Alz
- amoxicil-clarithromy-lansopraz
- argin-niac-yohi-gins-ginkgo-hb
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- buprenorphine-naloxone
- Central Vite
- Central-vite Performance
- cimetidine
- clarithromycin
- Daily Multiple
- Daily Multiple For Men 50+
- Diflucan
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- Estroblend
- Estroven Mood & Memory
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- Heartburn Relief
- isoniazid-rifamp-pyrazinamide
- itraconazole
- Ketek
- ketoconazole
- Maximum Daily Green
- Megavite Golden Years 55+
- Memory Complex
- Men's 50+ Daily Formula
- Multivital Performance
- mv with min-FA-lycopene-ginkgo
- mv,Ca,min-FA-herbal comp #223
- mv-FA-D3-K-lycop-lut-herb#220
- mv-iron-FA-Ca-beepoln-hb 101
- mv-iron-min-ginkgo b-ginseng
- mv-mn-FA-herbs190&215-digest#4
- Noxafil
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- One Daily For Men 50+ Advanced
- One Daily Men's 50+
- One Daily Women 50 Plus
- One-a-day Men's 50+ Advantage
- Onmel
- posaconazole
- Prevpac
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Sentra Pm
- Spectravite Performance
- Sporanox
- Sporanox Pulsepak
- Suboxone
- Tagamet Hb
- telithromycin
- Vfend
- Vfend Iv
- Vigraplex
- vinp-hupe-gink-a-cyst-phos-ace
- vit C-vit E-Se-ginkgo biloba
- voriconazole
- Women's 50+ Daily Formula
- Zubsolv
- Angle-closure glaucoma
Contraindicated
- Acute renal failure
- Coma
- Hemodynamic instability
- Obstructive pulmonary disease
- Pregnancy
- Shock
Severe
Moderate
- Chronic heart failure
- Hepatic cirrhosis
- Peripheral vasoconstriction
MIDAZOLAM HCL (MIDAZOLAM HCL/PF)
- Conscious sedation
- General anesthesia adjunct
- Sedation in intubated patient
- Induce anterograde amnesia
- Local anesthesia adjunct
- Preoperative anxiety
- Apnea
- Hypotension
- None
More Frequent
Severe
Less Severe
- None
- Cough
- Dizziness
- Drowsy
- Headache disorder
- Hiccups
- Induration of skin
- Injection site sequelae
- Nausea
- Visual changes
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute respiratory insufficiency
- Anaphylaxis
- Bronchospastic pulmonary disease
- Dyspnea
- Hyperventilation
- Involuntary muscle movement
- Laryngismus
- Respiratory depression
- Tachycardia
- Urticaria
- Wheezing
Less Severe
- Agitation
- Blurred vision
- Chills
- Delirium
- Excitement
- Lethargy
- Muscle rigidity
- Muscle weakness
- Nervousness
- Nystagmus
- Paresthesia
- Phlebitis after infusion
- Pruritus of skin
- Sialorrhea
- Skin rash
- Syncope
- Tachypnea
- Tremor
- Voice change
- Yawning
Contraindicated
None
Severe Precaution
Midazolam
Increased risk of hypotension, seizure with rapid injection. Monitor respiration. Decreased clearance.
Respiratory depression risk increases with concurrent opiate use. Use weight based dosing. Monitor closely.
- 1 Day – 29 Days
- Increased risk of hypotension, seizure with rapid injection. Monitor respiration. Decreased clearance.
- Respiratory depression risk increases with concurrent opiate use. Use weight based dosing. Monitor closely.
- 30 Days – 18 Years
- Increased risk of hypotension, seizure with rapid injection. Monitor respiration. Decreased clearance.
- Respiratory depression risk increases with concurrent opiate use. Use weight based dosing. Monitor closely.
Management or Monitoring Precaution
None
Midazolam
- Severity Level:
D
- Additional Notes: Insuff human data; possible risk of congenital malformations w/ benzodiazepines
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Midazolam
Insufficient human data available; manufacturer recommends caution
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Insufficient human data available; manufacturer recommends caution |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Midazolam
General-Increased risk for hypoxia, respiratory and cardiac arrest in the elderly. Use reduced dosages and administer with extreme caution. Neuro/Psych-Increased risk of cognitive impairment, delirium, falls, fractures, and motor vehicle crashes.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | Y | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- Giving midazolam by injection into a vein can sometimes cause severe breathing problems which could rarely lead to brain damage or be fatal. The risk of serious breathing problems is higher with high doses or if midazolam is given too quickly into a vein. Midazolam must be used only under close medical supervision.<br /><br /> Infants, children, older adults, or weak patients are more sensitive to the effects of midazolam. Lower doses should be used for these patients. Lower doses of midazolam should be used if a patient is also receiving other medications that cause drowsiness.<br /><br />Newborns must not be given midazolam by rapid injection because of the risk of very serious side effects. Using midazolam with opioid medications (such as codeine, hydrocodone) may increase your risk of very serious side effects, including death. To lower your risk, your doctor should use or have you use the smallest dose of midazolam that works, and use it for the shortest possible time. Get medical help right away if any of these very serious side effects occur: slow/shallow breathing, unusual lightheadedness, severe drowsiness/dizziness, difficulty waking up.
| Preoperative anxiety | |
| R45.0 | Nervousness |
| 0-9 | A-Z |
|---|---|
| R45.0 | Nervousness |
Formulary Reference Tool