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OMEPRAZOLE (OMEPRAZOLE)
- Duodenal ulcer
- Gastroesophageal reflux disease
- Duodenal ulcer due to h. pylori
- Erosive esophagitis
- Gastric hypersecretion with systemic mastocytosis
- Gastric ulcer
- Heartburn
- Helicobacter pylori gastritis
- Maintenance of healing erosive esophagitis
- Pathological gastric acid hypersecretory condition
- Zollinger-ellison syndrome
20 mg tablet,delayed release
- Dosage information is not available
10 mg capsule,delayed release
- 2 capsules (20 mg) by oral route once daily before a meal
20 mg capsule,delayed release
- 1 capsule (20 mg) by oral route once daily 30 minutes to 1 hour before a meal
40 mg capsule,delayed release
- 1 capsule (40 mg) by oral route once daily before a meal
Duodenal ulcer
- 1 capsule (20 mg) by oral route once daily before a meal
- 1 capsule (20 mg) by oral route once daily before a meal for 14 days
- 2 capsules (20 mg) by oral route once daily before a meal
- 1 capsule (20 mg) by oral route once daily before a meal for 28 days
- 1 capsule (20 mg) by oral route once daily 30 minutes to 1 hour before a meal
Duodenal ulcer due to h. pylori
- 2 capsules (20 mg) by oral route 2 times per day before meals incombination with amoxicillin and clarithromycin
- 2 capsules (20 mg) by oral route once daily before a meal in combination with amoxicillin and clarithromycin
- 2 capsules (20 mg) by oral route once daily before a meal for 18Days in combination with amoxicillin and clarithromycin
- 1 capsule (20 mg) by oral route 2 times per day before meals for10 days in combination with amoxicillin and clarithromycin
- 1 capsule (20 mg) by oral route once daily before a meal for 14 days in combination with clarithromycin
- 1 capsule (40 mg) by oral route once daily before a meal in combination with clarithromycin
- 2 capsules (40 mg) by oral route once daily before a meal for 14Days in combination with clarithromycin
Erosive esophagitis
- 1 capsule (20 mg) by oral route once daily before a meal
- 2 capsules (20 mg) by oral route once daily before a meal
- 1 capsule (20 mg) by oral route once daily before a meal for 28 days
- 1 capsule (20 mg) by oral route once daily before a meal for 56 days
- 1 capsule (20 mg) by oral route once daily 30 minutes to 1 hour before a meal
Gastric hypersecretion with systemic mastocytosis
- 1 capsule (20 mg) by oral route once daily before a meal
- 2 capsules (20 mg) by oral route once daily before a meal
- 1 capsule (20 mg) by oral route once daily 30 minutes to 1 hour before a meal
- 1 capsule (40 mg) by oral route once daily before a meal
- 1 capsule (40 mg) by oral route 2 times per day before a meal
- 1 capsule (40 mg) by oral route 3 times per day before a meal
- 2 capsules (40 mg) by oral route 2 times per day before meals
- 2 capsules (40 mg) by oral route once daily before a meal
- 2 capsules (40 mg) by oral route 3 times per day before meals
- 3 capsules (60 mg) by oral route 3 times per day before meals
- 3 capsules (60 mg) by oral route 2 times per day before meals
- 3 capsules (60 mg) by oral route once daily before a meal
- 2 capsules (80 mg) by oral route once daily before a meal
- 2 capsules (80 mg) by oral route 2 times per day before a meal
- 2 capsules (80 mg) by oral route 3 times per day before a meal
Gastric ulcer
- 2 capsules (40 mg) by oral route once daily before a meal for 28Days
- 2 capsules (40 mg) by oral route once daily before a meal for 56Days
- 1 capsule (40 mg) by oral route once daily before a meal
- 1 capsule (40 mg) by oral route once daily before a meal for 4 weeks
- 1 capsule (40 mg) by oral route once daily before a meal for 8 weeks
- 2 capsules (40 mg) by oral route once daily before a meal
Gastroesophageal reflux disease
- 1 capsule (20 mg) by oral route once daily before a meal
- 2 capsules (20 mg) by oral route once daily before a meal
- 2 capsules (20 mg) by oral route once daily before a meal for 28Days
- 2 capsules (20 mg) by oral route once daily before a meal for 56Days
- 1 capsule (20 mg) by oral route once daily before a meal for 28 days
- 1 capsule (20 mg) by oral route once daily 30 minutes to 1 hour before a meal
Heartburn
- 1 capsule (20 mg) by oral route once daily before a meal
- 1 capsule (20 mg) by oral route once daily before a meal for 28 days
- 1 capsule (20 mg) by oral route once daily 30 minutes to 1 hour before a meal
Helicobacter pylori gastritis
- 2 capsules (20 mg) by oral route 2 times per day before meals incombination with amoxicillin and clarithromycin
- 1 capsule (20 mg) by oral route 2 times per day before meals for10 days in combination with amoxicillin and clarithromycin
- 1 capsule (20 mg) by oral route once daily before a meal for 14 days in combination with clarithromycin
- 2 capsules (20 mg) by oral route 2 times per day before meals for 10 days in combination with amoxicillin and clarithromycin
- 1 capsule (40 mg) by oral route once daily before a meal for 14 days in combination with clarithromycin
- 1 capsule (40 mg) by oral route once daily before a meal in combination with clarithromycin
- 2 capsules (40 mg) by oral route once daily before a meal for 14Days in combination with clarithromycin
Pathological gastric acid hypersecretory condition
- 1 capsule (20 mg) by oral route once daily before a meal
- 2 capsules (20 mg) by oral route once daily before a meal
- 1 capsule (20 mg) by oral route once daily 30 minutes to 1 hour before a meal
- 1 capsule (40 mg) by oral route 2 times per day before a meal
- 1 capsule (40 mg) by oral route 3 times per day before a meal
- 2 capsules (40 mg) by oral route 2 times per day before meals
- 2 capsules (40 mg) by oral route once daily before a meal
- 2 capsules (40 mg) by oral route 3 times per day before meals
- 3 capsules (60 mg) by oral route 3 times per day before meals
- 3 capsules (60 mg) by oral route 2 times per day before meals
- 3 capsules (60 mg) by oral route once daily before a meal
- 2 capsules (80 mg) by oral route once daily before a meal
- 2 capsules (80 mg) by oral route 2 times per day before a meal
- 2 capsules (80 mg) by oral route 3 times per day before a meal
Zollinger-ellison syndrome
- 1 capsule (20 mg) by oral route once daily before a meal
- 2 capsules (20 mg) by oral route once daily before a meal
- 1 capsule (20 mg) by oral route once daily 30 minutes to 1 hour before a meal
- 1 capsule (40 mg) by oral route once daily before a meal
- 1 capsule (40 mg) by oral route 2 times per day before a meal
- 1 capsule (40 mg) by oral route 3 times per day before a meal
- 2 capsules (40 mg) by oral route 2 times per day before meals
- 2 capsules (40 mg) by oral route once daily before a meal
- 2 capsules (40 mg) by oral route 3 times per day before meals
- 3 capsules (60 mg) by oral route 3 times per day before meals
- 3 capsules (60 mg) by oral route 2 times per day before meals
- 3 capsules (60 mg) by oral route once daily before a meal
- 2 capsules (80 mg) by oral route once daily before a meal
- atazanavir
- Complera
- Edurant
- emtricitab-rilpivirine-tenofov
- nelfinavir
- Reyataz
- rilpivirine
- Viracept
Contraindicated
- Bosulif
- bosutinib
- Cellcept
- Cellcept Intravenous
- citalopram
- clobazam
- clopidogrel
- dasatinib
- erlotinib
- itraconazole
- ketoconazole
- methotrexate sodium
- methotrexate sodium (PF)
- mycophenolate mofetil
- mycophenolate mofetil HCl
- nilotinib
- Noxafil
- Onfi
- Onmel
- Plavix
- posaconazole
- Sporanox
- Sporanox Pulsepak
- Sprycel
- Tarceva
- Tasigna
Severe
Moderate
- Adderall
- Adderall Xr
- Amphetamine Salt Combo
- Astagraf Xl
- Ceftin
- cefuroxime axetil
- Celexa
- Cerebyx
- Dexedrine Spansule
- dextroamphetamine
- dextroamphetamine-amphetamine
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- escitalopram oxalate
- ethotoin
- fosphenytoin
- Hecoria
- Isentress
- Lexapro
- Methotrexate (anti-rheumatic)
- Peganone
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- Procentra
- Prograf
- raltegravir
- Rheumatrex
- tacrolimus
- Trexall
- Vfend
- Vfend Iv
- voriconazole
- Zenzedi
- None
Contraindicated
- Clostridium difficile infection
- Interstitial nephritis
- Subacute cutaneous lupus erythematosus
- Systemic lupus erythematosus
Severe
Moderate
- CYp2c19 poor metabolizer
- Disease of liver
- Fracture
- Hypomagnesemia
- Osteoporosis
- Vitamin b12 deficiency
OMEPRAZOLE (OMEPRAZOLE)
- Duodenal ulcer
- Gastroesophageal reflux disease
- Duodenal ulcer due to h. pylori
- Erosive esophagitis
- Gastric hypersecretion with systemic mastocytosis
- Gastric ulcer
- Heartburn
- Helicobacter pylori gastritis
- Maintenance of healing erosive esophagitis
- Pathological gastric acid hypersecretory condition
- Zollinger-ellison syndrome
- None
- Acute abdominal pain
- Diarrhea
- Flatulence
- Headache disorder
- Vomiting
More Frequent
Severe
Less Severe
- None
- Back pain
- Chest pain
- Constipation
- Cough
- Dizziness
- Fever
- General weakness
- Nausea
- Pruritus of skin
- Upper respiratory infection
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Agranulocytosis
- Anaphylaxis
- Anemia
- Angioedema
- Anterior ischemic optic neuropathy
- Atrophic gastritis
- Bradycardia
- Bronchospastic pulmonary disease
- Cardiac arrhythmia
- Cholestatic hepatitis
- Clostridium difficile infection
- Erythema multiforme
- Esophageal candidiasis
- Fracture
- Hematuria
- Hepatic failure
- Hepatitis
- Hyperbilirubinemia
- Hypoglycemic disorder
- Hyponatremia
- Increased alanine transaminase
- Increased aspartate transaminase
- Interstitial nephritis
- Leukocytosis
- Leukopenia
- Neutropenic disorder
- Optic neuritis
- Pancreatitis
- Pancytopenia
- Proteinuria
- Stevens-johnson syndrome
- Subacute cutaneous lupus erythematosus
- Systemic lupus erythematosus
- Thrombocytopenic disorder
- Toxic epidermal necrolysis
- Urticaria
Less Severe
- Abdominal distension
- Alopecia
- Anorexia
- Arthralgias
- Benign fundic gland polyposis of stomach
- Blurred vision
- Cramps
- Diplopia
- Discolored feces
- Dry eye
- Dry skin
- Dysgeusia
- Epistaxis
- Fatigue
- Glycosuria
- Gynecomastia
- Hyperhidrosis
- Hypertension
- Hypomagnesemia
- Irritable bowel syndrome
- Leg pain
- Malaise
- Muscle weakness
- Myalgias
- Ocular irritation
- Pain
- Palpitations
- Paresthesia
- Peripheral edema
- Petechiae
- Purpura
- Skin inflammation
- Skin photosensitivity
- Skin rash
- Sleep disorder
- Sore throat
- Stomatitis
- Tachycardia
- Testicular pain
- Tinnitus
- Tremor
- Urinary tract infection
- Vertigo
- Vitamin b12 deficiency
- Weight gain
- Xerostomia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Omeprazole (Oral)
Safety and efficacy not established age less than 1 year.
- 1 Day – 364 Days
- Safety and efficacy not established age less than 1 year.
Omeprazole
- Severity Level:
2
- Additional Notes: Limited data sug no increased risk for dev tox after 1st trim
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Omeprazole
Insufficient data available; low levels excreted into breast milk
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Insufficient data available; low levels excreted into breast milk |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Omeprazole
General-Prolonged use may dec absorption of Vitamin B-12. Avoid for >8 weeks duration unless for high risk patients (eg. oral corticosteroids or chronic NSAID use), erosive esophagitis, Barrett's esophagitis, pathologic hypersecretory condition, or demonstrated need for maint treatment. Musculoskeletal-Inc risk of fracture with high dose or use >1 year. Gastrointestinal-Long term use may be assoc w/ C. difficile or GI malignancy. Pulmonary-Long term use may be assoc w/pneumonia.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | N | N | Y | N |
BEERS: Y HEDIS: N STOPP: Y
No Known Risk
None
- None
| Duodenal ulcer | |
| K26 | Duodenal ulcer |
| K26.0 | Acute duodenal ulcer with hemorrhage |
| K26.1 | Acute duodenal ulcer with perforation |
| K26.2 | Acute duodenal ulcer with both hemorrhage and perforation |
| K26.3 | Acute duodenal ulcer without hemorrhage or perforation |
| K26.4 | Chronic or unspecified duodenal ulcer with hemorrhage |
| K26.5 | Chronic or unspecified duodenal ulcer with perforation |
| K26.6 | Chronic or unspecified duodenal ulcer with both hemorrhage and perforation |
| K26.7 | Chronic duodenal ulcer without hemorrhage or perforation |
| K26.9 | Duodenal ulcer, unspecified as acute or chronic, without hemorrhage or perforation |
| Duodenal ulcer due to h. pylori | |
| B96.81 | Helicobacter pylori [h. pylori] as the cause of diseases classified elsewhere |
| Erosive esophagitis | |
| K22.1 | Ulcer of esophagus |
| K22.10 | Ulcer of esophagus without bleeding |
| K22.11 | Ulcer of esophagus with bleeding |
| Gastric hypersecretion with systemic mastocytosis | |
| C96.21 | Aggressive systemic mastocytosis |
| D47.02 | Systemic mastocytosis |
| K31.89 | Other diseases of stomach and duodenum |
| Gastric ulcer | |
| K25 | Gastric ulcer |
| K25.0 | Acute gastric ulcer with hemorrhage |
| K25.1 | Acute gastric ulcer with perforation |
| K25.2 | Acute gastric ulcer with both hemorrhage and perforation |
| K25.3 | Acute gastric ulcer without hemorrhage or perforation |
| K25.4 | Chronic or unspecified gastric ulcer with hemorrhage |
| K25.5 | Chronic or unspecified gastric ulcer with perforation |
| K25.6 | Chronic or unspecified gastric ulcer with both hemorrhage and perforation |
| K25.7 | Chronic gastric ulcer without hemorrhage or perforation |
| K25.9 | Gastric ulcer, unspecified as acute or chronic, without hemorrhage or perforation |
| Gastroesophageal reflux disease | |
| K21 | Gastro-esophageal reflux disease |
| K21.0 | Gastro-esophageal reflux disease with esophagitis |
| K21.9 | Gastro-esophageal reflux disease without esophagitis |
| Heartburn | |
| R12 | Heartburn |
| Helicobacter pylori gastritis | |
| B96.81 | Helicobacter pylori [h. pylori] as the cause of diseases classified elsewhere |
| Maintenance of healing erosive esophagitis | |
| K22.1 | Ulcer of esophagus |
| K22.10 | Ulcer of esophagus without bleeding |
| K22.11 | Ulcer of esophagus with bleeding |
| Pathological gastric acid hypersecretory condition | |
| K31.89 | Other diseases of stomach and duodenum |
| Zollinger-ellison syndrome | |
| E16.4 | Increased secretion of gastrin |
| 0-9 | A-Z |
|---|---|
| B96.81 | Helicobacter pylori [h. pylori] as the cause of diseases classified elsewhere |
| B96.81 | Helicobacter pylori [h. pylori] as the cause of diseases classified elsewhere |
| C96.21 | Aggressive systemic mastocytosis |
| D47.02 | Systemic mastocytosis |
| E16.4 | Increased secretion of gastrin |
| K21 | Gastro-esophageal reflux disease |
| K21.0 | Gastro-esophageal reflux disease with esophagitis |
| K21.9 | Gastro-esophageal reflux disease without esophagitis |
| K22.1 | Ulcer of esophagus |
| K22.1 | Ulcer of esophagus |
| K22.10 | Ulcer of esophagus without bleeding |
| K22.10 | Ulcer of esophagus without bleeding |
| K22.11 | Ulcer of esophagus with bleeding |
| K22.11 | Ulcer of esophagus with bleeding |
| K25 | Gastric ulcer |
| K25.0 | Acute gastric ulcer with hemorrhage |
| K25.1 | Acute gastric ulcer with perforation |
| K25.2 | Acute gastric ulcer with both hemorrhage and perforation |
| K25.3 | Acute gastric ulcer without hemorrhage or perforation |
| K25.4 | Chronic or unspecified gastric ulcer with hemorrhage |
| K25.5 | Chronic or unspecified gastric ulcer with perforation |
| K25.6 | Chronic or unspecified gastric ulcer with both hemorrhage and perforation |
| K25.7 | Chronic gastric ulcer without hemorrhage or perforation |
| K25.9 | Gastric ulcer, unspecified as acute or chronic, without hemorrhage or perforation |
| K26 | Duodenal ulcer |
| K26.0 | Acute duodenal ulcer with hemorrhage |
| K26.1 | Acute duodenal ulcer with perforation |
| K26.2 | Acute duodenal ulcer with both hemorrhage and perforation |
| K26.3 | Acute duodenal ulcer without hemorrhage or perforation |
| K26.4 | Chronic or unspecified duodenal ulcer with hemorrhage |
| K26.5 | Chronic or unspecified duodenal ulcer with perforation |
| K26.6 | Chronic or unspecified duodenal ulcer with both hemorrhage and perforation |
| K26.7 | Chronic duodenal ulcer without hemorrhage or perforation |
| K26.9 | Duodenal ulcer, unspecified as acute or chronic, without hemorrhage or perforation |
| K31.89 | Other diseases of stomach and duodenum |
| K31.89 | Other diseases of stomach and duodenum |
| R12 | Heartburn |
Formulary Reference Tool