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PROPAFENONE HCL (PROPAFENONE HCL)
- Paroxysmal atrial fibrillation
- Prevention of recurrent atrial fibrillation
- Life-threatening ventricular tachycardia
- Paroxysmal atrial flutter
- Paroxysmal supraventricular tachycardia
150 mg tablet
- 1 tablet (150 mg) by oral route every 8 hours
225 mg tablet
- 1 tablet (225 mg) by oral route every 8 hours
300 mg tablet
- 1 tablet (300 mg) by oral route every 8 hours
propafenone 150 mg tablet
- 1 tablet (150 mg) by oral route every 8 hours
propafenone 225 mg tablet
- 1 tablet (225 mg) by oral route every 8 hours
propafenone 300 mg tablet
- 1 tablet (300 mg) by oral route every 8 hours
150 mg tablet
- 1 tablet (150 mg) by oral route every 8 hours
225 mg tablet
- 1 tablet (225 mg) by oral route every 8 hours
300 mg tablet
- 1 tablet (300 mg) by oral route every 8 hours
Life-threatening ventricular tachycardia
- 1 tablet (150 mg) by oral route every 8 hours
- 1 tablet (225 mg) by oral route every 8 hours
- 2 tablets (300 mg) by oral route every 8 hours
- 1 tablet (300 mg) by oral route every 8 hours
Paroxysmal supraventricular tachycardia
- 1 tablet (150 mg) by oral route every 8 hours
- 1 tablet (225 mg) by oral route every 8 hours
- 2 tablets (300 mg) by oral route every 8 hours
- 1 tablet (300 mg) by oral route every 8 hours
- amiodarone
- amiodarone in dextrose,iso-osm
- Aptivus
- artemether-lumefantrine
- Betapace
- Betapace Af
- Coartem
- Cordarone
- Corvert
- dextromethorphan-quinidine
- disopyramide
- dofetilide
- dronedarone
- droperidol
- fosamprenavir
- ibutilide fumarate
- Invirase
- Kaletra
- Lexiva
- lopinavir-ritonavir
- Multaq
- Nexterone
- Norpace
- Norpace Cr
- Norvir
- Norvir Soft Gelatin
- Nuedexta
- Orap
- Pacerone
- pimozide
- procainamide
- quinidine gluconate
- quinidine sulfate
- ritonavir
- saquinavir mesylate
- Sorine
- sotalol
- Sotalol Af
- Tikosyn
- tipranavir
Contraindicated
- arsenic trioxide
- Caprelsa
- chloroquine phosphate
- chlorpromazine
- dasatinib
- Digox
- digoxin
- Diskets
- Dolophine
- Fareston
- fingolimod
- Geodon
- Gilenya
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Invega
- Invega Sustenna
- isradipine
- Lanoxin
- Lanoxin Pediatric
- methadone
- Methadone Intensol
- Methadose
- mirabegron
- Myrbetriq
- Nebupent
- nilotinib
- norfloxacin
- Noroxin
- paliperidone
- paliperidone palmitate
- Pentam
- pentamidine
- Qualaquin
- quinine sulfate
- Sprycel
- Tasigna
- tetrabenazine
- tizanidine
- toremifene
- Trisenox
- vandetanib
- Xenazine
- Zanaflex
- ziprasidone HCl
- ziprasidone mesylate
Severe
Moderate
- Advair Diskus
- Advair Hfa
- alfuzosin
- amantadine HCl
- Anzemet
- Astagraf Xl
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- Azilect
- bedaquiline
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- clozapine
- Clozaril
- Complera
- Coumadin
- crizotinib
- Diflucan
- dolasetron
- Dutoprol
- Edurant
- Effexor Xr
- emtricitab-rilpivirine-tenofov
- Eovist
- eribulin
- escitalopram oxalate
- ezogabine
- Fazaclo
- felbamate
- Felbatol
- flecainide
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fluoxetine
- fluticasone-salmeterol
- foscarnet
- Foscavir
- gadoxetate
- granisetron
- granisetron (PF)
- Granisol
- Halaven
- Hecoria
- indapamide
- Inderal La
- Inderal Xl
- Innopran Xl
- isoniazid-rifamp-pyrazinamide
- Istodax
- Jantoven
- Ketek
- Lamisil
- lapatinib
- Levaquin
- Levaquin In 5 % Dextrose
- Levitra
- levofloxacin
- levofloxacin in D5W
- Lexapro
- lithium carbonate
- lithium citrate
- Lithobid
- Lopressor
- Lopressor Hct
- metoprolol su-hydrochlorothiaz
- metoprolol succinate
- metoprolol ta-hydrochlorothiaz
- metoprolol tartrate
- moexipril
- moexipril-hydrochlorothiazide
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Mycobutin
- Nexavar
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- Noxafil
- octreotide acetate
- olanzapine-fluoxetine
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- pasireotide
- pazopanib
- posaconazole
- Potiga
- Priftin
- Prograf
- propranolol
- propranolol-hydrochlorothiazid
- Prozac
- Prozac Weekly
- quetiapine
- rasagiline
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- rifapentine
- Rifater
- rilpivirine
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- romidepsin
- salmeterol
- Sancuso
- Sandostatin
- Sandostatin Lar Depot
- Sarafem
- Serevent Diskus
- Seroquel
- Seroquel Xr
- Signifor
- Sirturo
- Soltamox
- sorafenib
- sunitinib
- Sutent
- Symbyax
- tacrolimus
- tamoxifen
- telavancin
- telithromycin
- terbinafine
- Toprol Xl
- Tykerb
- Uniretic
- Univasc
- Uroxatral
- vardenafil
- vemurafenib
- venlafaxine
- Versacloz
- Vfend
- Vfend Iv
- Vibativ
- voriconazole
- Votrient
- warfarin
- Xalkori
- Zelboraf
- Zofran
- Zofran Odt
- Zuplenz
- Acute hypotension
- Agranulocytosis
- Atrioventricular block
- Bradycardia
- Bronchospastic pulmonary disease
- Brugada syndrome
- Bundle branch block
- Cardiogenic shock
- Chronic heart failure
- Hyperkalemia
- Hypokalemia
- Severe chronic obstructive pulmonary disease
- Torsades de pointes
Contraindicated
- 30 day risk period post-myocardial infarction
- Acute myocardial infarction
- Congenital long QT syndrome
- Myasthenia gravis
- Prolonged QT interval
- Severe coronary artery disease
- Sick sinus syndrome
- Structural disorder of heart
Severe
Moderate
- CYp2d6 poor metabolizer
- Disease of liver
- Kidney disease with reduction in GFR
PROPAFENONE HCL (PROPAFENONE HCL)
- Paroxysmal atrial fibrillation
- Prevention of recurrent atrial fibrillation
- Life-threatening ventricular tachycardia
- Paroxysmal atrial flutter
- Paroxysmal supraventricular tachycardia
- Ventricular tachycardia
- Constipation
- Dizziness
- Dysgeusia
- Dyspnea
- Edema
- Influenza
- Palpitations
- Symptoms of anxiety
- Upper respiratory infection
More Frequent
Severe
Less Severe
- Angina
- Atrioventricular block
- Chronic heart failure
- Blurred vision
- Chest pain
- Depression
- Diarrhea
- Ecchymosis
- Fatigue
- General weakness
- Headache disorder
- Nausea
- Rales
- Tremor
- Vomiting
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute myocardial infarction
- Acute respiratory insufficiency
- Agranulocytosis
- Atelectasis
- Atrial flutter
- Bradycardia
- Bundle branch block
- Cardiac arrhythmia
- Cerebrovascular accident
- Diabetes mellitus
- Gastrointestinal obstruction
- Gout
- Hemoptysis
- Hemorrhage
- Hepatomegaly
- Hypertension
- Hypokalemia
- Hypotension
- Neuromuscular blockade
- Neutropenic disorder
- Ocular hemorrhage
- Pancreatitis
- Paralysis
- Paroxysmal supraventricular tachycardia
- Peptic ulcer
- Pleural effusions
- Prolonged QT interval
- Pulmonary congestion
- Rectal bleeding
- Renal failure
- Retinal disorder
- Tendonitis
- Throat constriction
- Thrombocytopenic disorder
- Thromboembolic disorder
- Urinary retention
- Ventricular fibrillation
Less Severe
- Abdominal distension
- Acute abdominal pain
- Alopecia
- Anorexia
- Arthritis
- Ataxia
- Black tarry stools
- Blepharoptosis
- Bursitis
- Cough
- Cramps
- Dehydration
- Dementia
- Dry skin
- Duodenitis
- Dysarthria
- Dyspepsia
- Dysphagia
- Dysuria
- Epistaxis
- Erectile dysfunction
- Eructation
- Erythema
- Fever
- Gait abnormality
- Gastritis
- Gastroesophageal reflux disease
- Gingival bleeding
- Gingival pain
- Glossitis
- Halitosis
- Hypercholesterolemia
- Hyperglycemia
- Hyperhidrosis
- Hypertonia
- Hypesthesia
- Increased urinary frequency
- Insomnia
- Libido changes
- Lymphadenopathy
- Malaise
- Mastalgia
- Memory impairment
- Miosis
- Mood changes
- Muscle spasm
- Myalgias
- Nail disorders
- Neck pain
- Nightmares
- Nocturia
- Ocular inflammation
- Oliguria
- Pain
- Pallor
- Paresthesia
- Petechiae
- Prostatitis
- Pruritus of skin
- Pyuria
- Reduced visual acuity
- Rhinitis
- Sciatica
- Sensation of warmth
- Skin inflammation
- Sleep disorder
- Sore throat
- Sore tongue
- Stomatitis
- Syncope
- Tinnitus
- Urinary incontinence
- Urticaria
- Vertigo
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Propafenone
No safety and efficacy established in pediatrics.
- 1 Day – 18 Years
- No safety and efficacy established in pediatrics.
Propafenone
- Severity Level:
2
- Additional Notes: Limited human data do not suggest a clear association for development toxicity.
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Propafenone
Excretion occurs in humans, manufacturer suggests caution
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Excretion occurs in humans, manufacturer suggests caution |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Propafenone
Renal-Active metabolites excreted. No renal dosing information available. Slow dose escalation in initial treatment. Monitor overdose symptoms: hypotension, somnolence, bradycardia, intra-atrial and ventricular conduction disturbances. Hepatic-Highly metabolized. Decrease by 20-30% for hepatic impairment. Cardiovascular-Progressive AV block and QRS widening observed with increasing doses. Avoid use in patients with sick sinus syndrome.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | Y | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- Though this medication often gives great benefits to people with irregular heartbeat, it may rarely cause a serious new irregular heartbeat. Therefore, when starting treatment with this drug, your doctor may recommend that you stay in the hospital for proper monitoring and emergency medical treatment if needed. Talk with your doctor about the benefits and risks of taking this medication.
| Life-threatening ventricular tachycardia | |
| I47.2 | Ventricular tachycardia |
| Paroxysmal atrial fibrillation | |
| I48.0 | Paroxysmal atrial fibrillation |
| Paroxysmal atrial flutter | |
| I48.3 | Typical atrial flutter |
| I48.4 | Atypical atrial flutter |
| I48.92 | Unspecified atrial flutter |
| Paroxysmal supraventricular tachycardia | |
| I47.1 | Supraventricular tachycardia |
| Prevention of recurrent atrial fibrillation | |
| I48.0 | Paroxysmal atrial fibrillation |
| I48.1 | Persistent atrial fibrillation |
| I48.91 | Unspecified atrial fibrillation |
| 0-9 | A-Z |
|---|---|
| I47.1 | Supraventricular tachycardia |
| I47.2 | Ventricular tachycardia |
| I48.0 | Paroxysmal atrial fibrillation |
| I48.0 | Paroxysmal atrial fibrillation |
| I48.1 | Persistent atrial fibrillation |
| I48.3 | Typical atrial flutter |
| I48.4 | Atypical atrial flutter |
| I48.91 | Unspecified atrial fibrillation |
| I48.92 | Unspecified atrial flutter |
Formulary Reference Tool