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ZAFIRLUKAST (ZAFIRLUKAST)
- Maintenance therapy for asthma
10 mg tablet
- 2 tablets (20 mg) by oral route 2 times per day at least 1 hour before or 2 hours after meals
20 mg tablet
- 1 tablet (20 mg) by oral route 2 times per day at least 1 hour before or 2 hours after meals
10 mg tablet
- 2 tablets (20 mg) by oral route 2 times per day at least 1 hour before or 2 hours after meals
20 mg tablet
- 1 tablet (20 mg) by oral route 2 times per day at least 1 hour before or 2 hours after meals
Maintenance therapy for asthma
- 2 tablets (20 mg) by oral route 2 times per day at least 1 hour before or 2 hours after meals
- 2 tablets (20 mg) by oral route every 12 hours at least 1 hour before or 2 hours after meals
- 1 tablet (20 mg) by oral route 2 times per day at least 1 hour before or 2 hours after meals
- 1 tablet (20 mg) by oral route every 12 hours at least 1 hour before or 2 hours after meals
- None
Contraindicated
- None
Severe
Moderate
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- Anaprox
- Anaprox Ds
- Ansaid
- Arthrotec 50
- Caldolor
- Cambia
- Cataflam
- Celebrex
- celecoxib
- Child Ibuprofen
- Children's Advil
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- Cold & Sinus Pain Relief
- Cold-sinus Relief
- Coumadin
- diclofenac epolamine
- diclofenac potassium
- diclofenac sodium
- diclofenac submicronized
- diclofenac-misoprostol
- Duexis
- Ec-naprosyn
- Feldene
- Flanax
- Flector
- flurbiprofen
- hydrocodone-ibuprofen
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-oxycodone
- ibuprofen-phenylephrine HCl
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- Jantoven
- Medi-profen
- Mediproxen
- meloxicam
- Midol (naproxen)
- Mobic
- Motrin Ib
- Motrin Pm
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- Neoprofen (ibuprofen Lysn)(pf)
- piroxicam
- Provil
- pseudoephedrine-ibuprofen
- Reprexain
- Sinus & Cold-d
- Vicoprofen
- Vimovo
- Voltaren-xr
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- warfarin
- Zipsor
- Zorvolex
- Disease of liver
- Hepatic cirrhosis
Contraindicated
- Abnormal hepatic function tests
Severe
Moderate
- Anxiety disorder
- Depression
- Dream disorder
- Hallucinations
- Insomnia
- Mood changes
- Nervousness
- Suicidal ideation
- Tremor
ZAFIRLUKAST (ZAFIRLUKAST)
- Maintenance therapy for asthma
- None
- None
More Frequent
Severe
Less Severe
- None
- Headache disorder
- Nausea
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute hepatic failure
- Agranulocytosis
- Angioedema
- Bruising
- Disease of liver
- Drug-induced hepatitis
- Eosinophilic pneumonia
- Hemorrhage
- Hepatitis
- Hyperbilirubinemia
- Hypersensitivity angiitis
- Neutropenic disorder
- Suicidal
- Suicidal ideation
- Urticaria
Less Severe
- Abdominal pain with cramps
- Aggressive behavior
- Agitation
- Arthralgias
- Depression
- Diarrhea
- Dream disorder
- Dyspepsia
- Edema
- Eosinophilia
- Fever
- Hallucinations
- Insomnia
- Irritability
- Malaise
- Myalgias
- Nervousness
- Pruritus of skin
- Symptoms of anxiety
- Tremor
- Vomiting
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Zafirlukast
Safety and efficacy not established in pediatrics age < 5 years.
Monitor for neuropsychiatric and/or behavioral changes.
- 1 Day – 5 Years
- Safety and efficacy not established in pediatrics age < 5 years.
- Monitor for neuropsychiatric and/or behavioral changes.
- 5 Years – 18 Years
- Safety and efficacy not established in pediatrics age < 5 years.
- Monitor for neuropsychiatric and/or behavioral changes.
Zafirlukast
- Severity Level:
B
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Zafirlukast
Insufficient human data; excreted in low amounts
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Insufficient human data; excreted in low amounts |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Zafirlukast
Elderly may show less improvement in efficacy measures.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | Y | N | N | Y | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Maintenance therapy for asthma | |
| J45 | Asthma |
| J45.2 | Mild intermittent asthma |
| J45.20 | Mild intermittent asthma, uncomplicated |
| J45.3 | Mild persistent asthma |
| J45.30 | Mild persistent asthma, uncomplicated |
| J45.4 | Moderate persistent asthma |
| J45.40 | Moderate persistent asthma, uncomplicated |
| J45.5 | Severe persistent asthma |
| J45.50 | Severe persistent asthma, uncomplicated |
| J45.9 | Other and unspecified asthma |
| J45.90 | Unspecified asthma |
| J45.909 | Unspecified asthma, uncomplicated |
| 0-9 | A-Z |
|---|---|
| J45 | Asthma |
| J45.2 | Mild intermittent asthma |
| J45.20 | Mild intermittent asthma, uncomplicated |
| J45.3 | Mild persistent asthma |
| J45.30 | Mild persistent asthma, uncomplicated |
| J45.4 | Moderate persistent asthma |
| J45.40 | Moderate persistent asthma, uncomplicated |
| J45.5 | Severe persistent asthma |
| J45.50 | Severe persistent asthma, uncomplicated |
| J45.9 | Other and unspecified asthma |
| J45.90 | Unspecified asthma |
| J45.909 | Unspecified asthma, uncomplicated |
Formulary Reference Tool