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NITROFURANTOIN MONO-MACRO (NITROFURANTOIN MONOHYDRATE/MACROCRYSTALS)
- Bacterial urinary tract infection
- E. coli urinary tract infection
- Staphylococcus saprophyticus urinary tract infection
nitrofurantoin monohydrate/macrocrystals 100 mg capsule
- 1 capsule (100 mg) by oral route every 12 hours with food
100 mg capsule
- 1 capsule (100 mg) by oral route every 12 hours with food
Bacterial urinary tract infection
- 1 capsule (100 mg) by oral route every 12 hours with food for 7 days
- 1 capsule (100 mg) by oral route every 12 hours with food
- 1 capsule (100 mg) by oral route 2 times per day with food
- 1 capsule (100 mg) by oral route 2 times per day with food for 7Days
E. coli urinary tract infection
- 1 capsule (100 mg) by oral route every 12 hours with food for 7 days
- 1 capsule (100 mg) by oral route every 12 hours with food
- 1 capsule (100 mg) by oral route 2 times per day with food
- 1 capsule (100 mg) by oral route 2 times per day with food for 7Days
Staphylococcus saprophyticus urinary tract infection
- 1 capsule (100 mg) by oral route every 12 hours with food for 7 days
- 1 capsule (100 mg) by oral route every 12 hours with food
- 1 capsule (100 mg) by oral route 2 times per day with food
- 1 capsule (100 mg) by oral route 2 times per day with food for 7Days
- Al hyd-Mg tr-alg ac-sod bicarb
- Antacid Tablet
- Foaming Antacid
- Gaviscon
- typhoid vaccine
- Vivotif Berna Vaccine
Contraindicated
- None
Severe
Moderate
- None
- Anuria
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Drug-induced hepatitis
- Glucose-6-phosphate dehydrogenase (g6Pd) deficiency
- Hemolytic anemia from PK and g6PD deficiencies
- Oliguria
Contraindicated
- Acute hepatitis
- Cholestatic hepatitis
- Chronic hepatitis
- Clostridium difficile infection
- Interstitial pneumonitis
- Kidney disease with likely reduction in GFR
- Obstructive hyperbilirubinemia
- Optic neuritis
- Peripheral neuropathy
- Pulmonary fibrosis
- Vitamin B deficiency
Severe
Moderate
- Diabetes mellitus
NITROFURANTOIN MONO-MACRO (NITROFURANTOIN MONOHYDRATE/MACROCRYSTALS)
- Bacterial urinary tract infection
- E. coli urinary tract infection
- Staphylococcus saprophyticus urinary tract infection
- Interstitial pneumonitis
- Anorexia
- Headache disorder
- Nausea
- Urine discoloration
- Vomiting
More Frequent
Severe
Less Severe
- Granulocytopenic disorder
- Leukopenia
- Megaloblastic anemia
- Polyneuropathy
- Acute abdominal pain
- Diarrhea
- Flatulence
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Agranulocytosis
- Allergic dermatitis
- Anaphylaxis
- Clostridium difficile infection
- Erythema multiforme
- Exfoliative dermatitis
- Glucose-6-phosphate dehydrogenase deficiency anemia
- Hemolytic anemia
- Hepatic necrosis
- Hepatitis
- Idiopathic intracranial hypertension
- Increased alanine transaminase
- Increased aspartate transaminase
- Lupus-like syndrome
- Methemoglobinemia
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Optic neuritis
- Pancreatitis
- Peripheral neuropathy
- Pruritus of skin
- Pulmonary fibrosis
- Sialoadenitis
- Skin rash
- Stevens-johnson syndrome
- Thrombocytopenic disorder
- Urticaria
- Vasculitis
Less Severe
- Alopecia
- Amblyopia
- Chills
- Constipation
- Dizziness
- Drowsy
- Dyspepsia
- Fever
- General weakness
- Malaise
- Nystagmus
- Vertigo
Contraindicated
Nitrofurantoin
May cause hemolytic anemia in neonates under 1 month of age.
- 1 Day – 29 Days
- 1 May cause hemolytic anemia in neonates under 1 month of age.
Severe Precaution
None
Management or Monitoring Precaution
None
Nitrofurantoin
- Severity Level:
B
- Additional Notes: Contraindicated at term (38 to 42 weeks gestation),d/t risk of hemolytic anemia
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Nitrofurantoin
Contraindicated in g6Pd deficient infants and <1 mo d/t hemolytic anemia risk
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Drug shown to have adverse effect | Contraindicated in g6Pd deficient infants and <1 mo d/t hemolytic anemia risk |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Nitrofurantoin
Renal-Beers Criteria contraindicates use in CrCL<30mL/min. due to increased risk for neuropathy, hepatic/pulmonary fibrosis. Neuro/Psych-Peripheral neuropathy risk particularly with long term UTI suppression and renal dysfunction. Pulmonary-Interstitial pneumonitis/fibrosis risk. Hepatic-Case reports of severe hepatotoxicity in the elderly on long term UTI suppressive therapy.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | N | Y | Y | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- None
| Bacterial urinary tract infection | |
| N30.0 | Acute cystitis |
| N30.00 | Acute cystitis without hematuria |
| N30.01 | Acute cystitis with hematuria |
| N30.9 | Cystitis, unspecified |
| N30.90 | Cystitis, unspecified without hematuria |
| N30.91 | Cystitis, unspecified with hematuria |
| N39.0 | Urinary tract infection, site not specified |
| O23.0 | Infections of kidney in pregnancy |
| O23.00 | Infections of kidney in pregnancy, unspecified trimester |
| O23.01 | Infections of kidney in pregnancy, first trimester |
| O23.02 | Infections of kidney in pregnancy, second trimester |
| O23.03 | Infections of kidney in pregnancy, third trimester |
| O23.1 | Infections of bladder in pregnancy |
| O23.10 | Infections of bladder in pregnancy, unspecified trimester |
| O23.11 | Infections of bladder in pregnancy, first trimester |
| O23.12 | Infections of bladder in pregnancy, second trimester |
| O23.13 | Infections of bladder in pregnancy, third trimester |
| O23.2 | Infections of urethra in pregnancy |
| O23.20 | Infections of urethra in pregnancy, unspecified trimester |
| O23.21 | Infections of urethra in pregnancy, first trimester |
| O23.22 | Infections of urethra in pregnancy, second trimester |
| O23.23 | Infections of urethra in pregnancy, third trimester |
| O23.3 | Infections of other parts of urinary tract in pregnancy |
| O23.30 | Infections of other parts of urinary tract in pregnancy, unspecified trimester |
| O23.31 | Infections of other parts of urinary tract in pregnancy, first trimester |
| O23.32 | Infections of other parts of urinary tract in pregnancy, second trimester |
| O23.33 | Infections of other parts of urinary tract in pregnancy, third trimester |
| O23.4 | Unspecified infection of urinary tract in pregnancy |
| O23.40 | Unspecified infection of urinary tract in pregnancy, unspecified trimester |
| O23.41 | Unspecified infection of urinary tract in pregnancy, first trimester |
| O23.42 | Unspecified infection of urinary tract in pregnancy, second trimester |
| O23.43 | Unspecified infection of urinary tract in pregnancy, third trimester |
| O23.90 | Unspecified genitourinary tract infection in pregnancy, unspecified trimester |
| O23.91 | Unspecified genitourinary tract infection in pregnancy, first trimester |
| O23.92 | Unspecified genitourinary tract infection in pregnancy, second trimester |
| O23.93 | Unspecified genitourinary tract infection in pregnancy, third trimester |
| P39.3 | Neonatal urinary tract infection |
| T83 | Complications of genitourinary prosthetic devices, implants and grafts |
| T83.5 | Infection and inflammatory reaction due to prosthetic device, implant and graft in urinary system |
| T83.51 | Infection and inflammatory reaction due to urinary catheter |
| T83.59 | Infection and inflammatory reaction due to prosthetic device, implant and graft in urinary system |
| T83.6 | Infection and inflammatory reaction due to prosthetic device, implant and graft in genital tract |
| E. coli urinary tract infection | |
| B96.2 | Escherichia coli [e. coli ] as the cause of diseases classified elsewhere |
| B96.20 | Unspecified escherichia coli [e. coli] as the cause of diseases classified elsewhere |
| B96.29 | Other escherichia coli [e. coli] as the cause of diseases classified elsewhere |
| N30.0 | Acute cystitis |
| N30.00 | Acute cystitis without hematuria |
| N30.01 | Acute cystitis with hematuria |
| N30.9 | Cystitis, unspecified |
| N30.90 | Cystitis, unspecified without hematuria |
| N30.91 | Cystitis, unspecified with hematuria |
| N39.0 | Urinary tract infection, site not specified |
| O23.0 | Infections of kidney in pregnancy |
| O23.00 | Infections of kidney in pregnancy, unspecified trimester |
| O23.01 | Infections of kidney in pregnancy, first trimester |
| O23.02 | Infections of kidney in pregnancy, second trimester |
| O23.03 | Infections of kidney in pregnancy, third trimester |
| O23.1 | Infections of bladder in pregnancy |
| O23.10 | Infections of bladder in pregnancy, unspecified trimester |
| O23.11 | Infections of bladder in pregnancy, first trimester |
| O23.12 | Infections of bladder in pregnancy, second trimester |
| O23.13 | Infections of bladder in pregnancy, third trimester |
| O23.2 | Infections of urethra in pregnancy |
| O23.20 | Infections of urethra in pregnancy, unspecified trimester |
| O23.21 | Infections of urethra in pregnancy, first trimester |
| O23.22 | Infections of urethra in pregnancy, second trimester |
| O23.23 | Infections of urethra in pregnancy, third trimester |
| O23.3 | Infections of other parts of urinary tract in pregnancy |
| O23.30 | Infections of other parts of urinary tract in pregnancy, unspecified trimester |
| O23.31 | Infections of other parts of urinary tract in pregnancy, first trimester |
| O23.32 | Infections of other parts of urinary tract in pregnancy, second trimester |
| O23.33 | Infections of other parts of urinary tract in pregnancy, third trimester |
| O23.4 | Unspecified infection of urinary tract in pregnancy |
| O23.40 | Unspecified infection of urinary tract in pregnancy, unspecified trimester |
| O23.41 | Unspecified infection of urinary tract in pregnancy, first trimester |
| O23.42 | Unspecified infection of urinary tract in pregnancy, second trimester |
| O23.43 | Unspecified infection of urinary tract in pregnancy, third trimester |
| O23.9 | Unspecified genitourinary tract infection in pregnancy |
| O23.90 | Unspecified genitourinary tract infection in pregnancy, unspecified trimester |
| O23.91 | Unspecified genitourinary tract infection in pregnancy, first trimester |
| O23.92 | Unspecified genitourinary tract infection in pregnancy, second trimester |
| O23.93 | Unspecified genitourinary tract infection in pregnancy, third trimester |
| Staphylococcus saprophyticus urinary tract infection | |
| B95.7 | Other staphylococcus as the cause of diseases classified elsewhere |
| N30.0 | Acute cystitis |
| N30.00 | Acute cystitis without hematuria |
| N30.01 | Acute cystitis with hematuria |
| N30.9 | Cystitis, unspecified |
| N30.90 | Cystitis, unspecified without hematuria |
| N30.91 | Cystitis, unspecified with hematuria |
| N39.0 | Urinary tract infection, site not specified |
| O03.38 | Urinary tract infection following incomplete spontaneous abortion |
| O03.88 | Urinary tract infection following complete or unspecified spontaneous abortion |
| O04.88 | Urinary tract infection following (induced) termination of pregnancy |
| O07.38 | Urinary tract infection following failed attempted termination of pregnancy |
| O08.83 | Urinary tract infection following an ectopic and molar pregnancy |
| O23.0 | Infections of kidney in pregnancy |
| O23.00 | Infections of kidney in pregnancy, unspecified trimester |
| O23.01 | Infections of kidney in pregnancy, first trimester |
| O23.02 | Infections of kidney in pregnancy, second trimester |
| O23.03 | Infections of kidney in pregnancy, third trimester |
| O23.1 | Infections of bladder in pregnancy |
| O23.10 | Infections of bladder in pregnancy, unspecified trimester |
| O23.11 | Infections of bladder in pregnancy, first trimester |
| O23.12 | Infections of bladder in pregnancy, second trimester |
| O23.13 | Infections of bladder in pregnancy, third trimester |
| O23.2 | Infections of urethra in pregnancy |
| O23.20 | Infections of urethra in pregnancy, unspecified trimester |
| O23.21 | Infections of urethra in pregnancy, first trimester |
| O23.22 | Infections of urethra in pregnancy, second trimester |
| O23.23 | Infections of urethra in pregnancy, third trimester |
| O23.3 | Infections of other parts of urinary tract in pregnancy |
| O23.30 | Infections of other parts of urinary tract in pregnancy, unspecified trimester |
| O23.31 | Infections of other parts of urinary tract in pregnancy, first trimester |
| O23.32 | Infections of other parts of urinary tract in pregnancy, second trimester |
| O23.33 | Infections of other parts of urinary tract in pregnancy, third trimester |
| O23.4 | Unspecified infection of urinary tract in pregnancy |
| O23.40 | Unspecified infection of urinary tract in pregnancy, unspecified trimester |
| O23.41 | Unspecified infection of urinary tract in pregnancy, first trimester |
| O23.42 | Unspecified infection of urinary tract in pregnancy, second trimester |
| O23.43 | Unspecified infection of urinary tract in pregnancy, third trimester |
| O23.9 | Unspecified genitourinary tract infection in pregnancy |
| O23.90 | Unspecified genitourinary tract infection in pregnancy, unspecified trimester |
| O23.91 | Unspecified genitourinary tract infection in pregnancy, first trimester |
| O23.92 | Unspecified genitourinary tract infection in pregnancy, second trimester |
| O23.93 | Unspecified genitourinary tract infection in pregnancy, third trimester |
| O86.2 | Urinary tract infection following delivery |
| O86.20 | Urinary tract infection following delivery, unspecified |
| O86.21 | Infection of kidney following delivery |
| O86.22 | Infection of bladder following delivery |
| O86.29 | Other urinary tract infection following delivery |
| P39.3 | Neonatal urinary tract infection |
| 0-9 | A-Z |
|---|---|
| B95.7 | Other staphylococcus as the cause of diseases classified elsewhere |
| B96.2 | Escherichia coli [e. coli ] as the cause of diseases classified elsewhere |
| B96.20 | Unspecified escherichia coli [e. coli] as the cause of diseases classified elsewhere |
| B96.29 | Other escherichia coli [e. coli] as the cause of diseases classified elsewhere |
| N30.0 | Acute cystitis |
| N30.0 | Acute cystitis |
| N30.0 | Acute cystitis |
| N30.00 | Acute cystitis without hematuria |
| N30.00 | Acute cystitis without hematuria |
| N30.00 | Acute cystitis without hematuria |
| N30.01 | Acute cystitis with hematuria |
| N30.01 | Acute cystitis with hematuria |
| N30.01 | Acute cystitis with hematuria |
| N30.9 | Cystitis, unspecified |
| N30.9 | Cystitis, unspecified |
| N30.9 | Cystitis, unspecified |
| N30.90 | Cystitis, unspecified without hematuria |
| N30.90 | Cystitis, unspecified without hematuria |
| N30.90 | Cystitis, unspecified without hematuria |
| N30.91 | Cystitis, unspecified with hematuria |
| N30.91 | Cystitis, unspecified with hematuria |
| N30.91 | Cystitis, unspecified with hematuria |
| N39.0 | Urinary tract infection, site not specified |
| N39.0 | Urinary tract infection, site not specified |
| N39.0 | Urinary tract infection, site not specified |
| O03.38 | Urinary tract infection following incomplete spontaneous abortion |
| O03.88 | Urinary tract infection following complete or unspecified spontaneous abortion |
| O04.88 | Urinary tract infection following (induced) termination of pregnancy |
| O07.38 | Urinary tract infection following failed attempted termination of pregnancy |
| O08.83 | Urinary tract infection following an ectopic and molar pregnancy |
| O23.0 | Infections of kidney in pregnancy |
| O23.0 | Infections of kidney in pregnancy |
| O23.0 | Infections of kidney in pregnancy |
| O23.00 | Infections of kidney in pregnancy, unspecified trimester |
| O23.00 | Infections of kidney in pregnancy, unspecified trimester |
| O23.00 | Infections of kidney in pregnancy, unspecified trimester |
| O23.01 | Infections of kidney in pregnancy, first trimester |
| O23.01 | Infections of kidney in pregnancy, first trimester |
| O23.01 | Infections of kidney in pregnancy, first trimester |
| O23.02 | Infections of kidney in pregnancy, second trimester |
| O23.02 | Infections of kidney in pregnancy, second trimester |
| O23.02 | Infections of kidney in pregnancy, second trimester |
| O23.03 | Infections of kidney in pregnancy, third trimester |
| O23.03 | Infections of kidney in pregnancy, third trimester |
| O23.03 | Infections of kidney in pregnancy, third trimester |
| O23.1 | Infections of bladder in pregnancy |
| O23.1 | Infections of bladder in pregnancy |
| O23.1 | Infections of bladder in pregnancy |
| O23.10 | Infections of bladder in pregnancy, unspecified trimester |
| O23.10 | Infections of bladder in pregnancy, unspecified trimester |
| O23.10 | Infections of bladder in pregnancy, unspecified trimester |
| O23.11 | Infections of bladder in pregnancy, first trimester |
| O23.11 | Infections of bladder in pregnancy, first trimester |
| O23.11 | Infections of bladder in pregnancy, first trimester |
| O23.12 | Infections of bladder in pregnancy, second trimester |
| O23.12 | Infections of bladder in pregnancy, second trimester |
| O23.12 | Infections of bladder in pregnancy, second trimester |
| O23.13 | Infections of bladder in pregnancy, third trimester |
| O23.13 | Infections of bladder in pregnancy, third trimester |
| O23.13 | Infections of bladder in pregnancy, third trimester |
| O23.2 | Infections of urethra in pregnancy |
| O23.2 | Infections of urethra in pregnancy |
| O23.2 | Infections of urethra in pregnancy |
| O23.20 | Infections of urethra in pregnancy, unspecified trimester |
| O23.20 | Infections of urethra in pregnancy, unspecified trimester |
| O23.20 | Infections of urethra in pregnancy, unspecified trimester |
| O23.21 | Infections of urethra in pregnancy, first trimester |
| O23.21 | Infections of urethra in pregnancy, first trimester |
| O23.21 | Infections of urethra in pregnancy, first trimester |
| O23.22 | Infections of urethra in pregnancy, second trimester |
| O23.22 | Infections of urethra in pregnancy, second trimester |
| O23.22 | Infections of urethra in pregnancy, second trimester |
| O23.23 | Infections of urethra in pregnancy, third trimester |
| O23.23 | Infections of urethra in pregnancy, third trimester |
| O23.23 | Infections of urethra in pregnancy, third trimester |
| O23.3 | Infections of other parts of urinary tract in pregnancy |
| O23.3 | Infections of other parts of urinary tract in pregnancy |
| O23.3 | Infections of other parts of urinary tract in pregnancy |
| O23.30 | Infections of other parts of urinary tract in pregnancy, unspecified trimester |
| O23.30 | Infections of other parts of urinary tract in pregnancy, unspecified trimester |
| O23.30 | Infections of other parts of urinary tract in pregnancy, unspecified trimester |
| O23.31 | Infections of other parts of urinary tract in pregnancy, first trimester |
| O23.31 | Infections of other parts of urinary tract in pregnancy, first trimester |
| O23.31 | Infections of other parts of urinary tract in pregnancy, first trimester |
| O23.32 | Infections of other parts of urinary tract in pregnancy, second trimester |
| O23.32 | Infections of other parts of urinary tract in pregnancy, second trimester |
| O23.32 | Infections of other parts of urinary tract in pregnancy, second trimester |
| O23.33 | Infections of other parts of urinary tract in pregnancy, third trimester |
| O23.33 | Infections of other parts of urinary tract in pregnancy, third trimester |
| O23.33 | Infections of other parts of urinary tract in pregnancy, third trimester |
| O23.4 | Unspecified infection of urinary tract in pregnancy |
| O23.4 | Unspecified infection of urinary tract in pregnancy |
| O23.4 | Unspecified infection of urinary tract in pregnancy |
| O23.40 | Unspecified infection of urinary tract in pregnancy, unspecified trimester |
| O23.40 | Unspecified infection of urinary tract in pregnancy, unspecified trimester |
| O23.40 | Unspecified infection of urinary tract in pregnancy, unspecified trimester |
| O23.41 | Unspecified infection of urinary tract in pregnancy, first trimester |
| O23.41 | Unspecified infection of urinary tract in pregnancy, first trimester |
| O23.41 | Unspecified infection of urinary tract in pregnancy, first trimester |
| O23.42 | Unspecified infection of urinary tract in pregnancy, second trimester |
| O23.42 | Unspecified infection of urinary tract in pregnancy, second trimester |
| O23.42 | Unspecified infection of urinary tract in pregnancy, second trimester |
| O23.43 | Unspecified infection of urinary tract in pregnancy, third trimester |
| O23.43 | Unspecified infection of urinary tract in pregnancy, third trimester |
| O23.43 | Unspecified infection of urinary tract in pregnancy, third trimester |
| O23.9 | Unspecified genitourinary tract infection in pregnancy |
| O23.9 | Unspecified genitourinary tract infection in pregnancy |
| O23.90 | Unspecified genitourinary tract infection in pregnancy, unspecified trimester |
| O23.90 | Unspecified genitourinary tract infection in pregnancy, unspecified trimester |
| O23.90 | Unspecified genitourinary tract infection in pregnancy, unspecified trimester |
| O23.91 | Unspecified genitourinary tract infection in pregnancy, first trimester |
| O23.91 | Unspecified genitourinary tract infection in pregnancy, first trimester |
| O23.91 | Unspecified genitourinary tract infection in pregnancy, first trimester |
| O23.92 | Unspecified genitourinary tract infection in pregnancy, second trimester |
| O23.92 | Unspecified genitourinary tract infection in pregnancy, second trimester |
| O23.92 | Unspecified genitourinary tract infection in pregnancy, second trimester |
| O23.93 | Unspecified genitourinary tract infection in pregnancy, third trimester |
| O23.93 | Unspecified genitourinary tract infection in pregnancy, third trimester |
| O23.93 | Unspecified genitourinary tract infection in pregnancy, third trimester |
| O86.2 | Urinary tract infection following delivery |
| O86.20 | Urinary tract infection following delivery, unspecified |
| O86.21 | Infection of kidney following delivery |
| O86.22 | Infection of bladder following delivery |
| O86.29 | Other urinary tract infection following delivery |
| P39.3 | Neonatal urinary tract infection |
| P39.3 | Neonatal urinary tract infection |
| T83 | Complications of genitourinary prosthetic devices, implants and grafts |
| T83.5 | Infection and inflammatory reaction due to prosthetic device, implant and graft in urinary system |
| T83.51 | Infection and inflammatory reaction due to urinary catheter |
| T83.59 | Infection and inflammatory reaction due to prosthetic device, implant and graft in urinary system |
| T83.6 | Infection and inflammatory reaction due to prosthetic device, implant and graft in genital tract |
Formulary Reference Tool