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JUXTAPID (LOMITAPIDE MESYLATE)
- Homozygous familial hypercholesterolemia
10 mg capsule
- 1 capsule (10 mg) by oral route once daily on an empty stomach, at least 2 hours after the evening meal swallowing whole with water.
20 mg capsule
- 3 capsules (60 mg) by oral route once daily on an empty stomach,at least 2 hours after the evening meal swallowing whole with water.
30 mg capsule
- 1 capsule (30 mg) by oral route once daily on an empty stomach, at least 2 hours after the evening meal swallowing whole with water.
40 mg capsule
- 1 capsule (40 mg) by oral route once daily on an empty stomach, at least 2 hours after the evening meal swallowing whole with water.
5 mg capsule
- 1 capsule (5 mg) by oral route once daily on an empty stomach, at least 2 hours after the evening meal swallowing whole with water.
60 mg capsule
- 1 capsule (60 mg) by oral route once daily on an empty stomach, at least 2 hours after the evening meal swallowing whole with water.
Homozygous familial hypercholesterolemia
- 1 capsule (5 mg) by oral route once daily on an empty stomach, at least 2 hours after the evening meal swallowing whole with water. Donot chew, open, dissolve and/or crush.
- 1 capsule (5 mg) by oral route once daily on an empty stomach, at least 2 hours after the evening meal swallowing whole with water.
- 2 capsules (10 mg) by oral route once daily on an empty stomach,at least 2 hours after the evening meal swallowing whole with water. Do not chew, open, dissolve and/or crush.
- 1 capsule (10 mg) by oral route once daily on an empty stomach, at least 2 hours after the evening meal swallowing whole with water. Do not chew, open, dissolve and/or crush.
- 1 capsule (10 mg) by oral route once daily on an empty stomach, at least 2 hours after the evening meal swallowing whole with water.
- 2 capsules (20 mg) by oral route once daily on an empty stomach,at least 2 hours after the evening meal swallowing whole with water. Do not chew, open, dissolve and/or crush.
- 1 capsule (20 mg) by oral route once daily on an empty stomach, at least 2 hours after the evening meal swallowing whole with water. Do not chew, open, dissolve and/or crush.
- 1 capsule (30 mg) by oral route once daily on an empty stomach, at least 2 hours after the evening meal swallowing whole with water.
- 2 capsules (40 mg) by oral route once daily on an empty stomach,at least 2 hours after the evening meal swallowing whole with water. Do not chew, open, dissolve and/or crush.
- 1 capsule (40 mg) by oral route once daily on an empty stomach, at least 2 hours after the evening meal swallowing whole with water.
- 1 capsule (60 mg) by oral route once daily on an empty stomach, at least 2 hours after the evening meal swallowing whole with water.
- 3 capsules (60 mg) by oral route once daily on an empty stomach,at least 2 hours after the evening meal swallowing whole with water. Do not chew, open, dissolve and/or crush.
- 2 capsules (60 mg) by oral route once daily on an empty stomach,at least 2 hours after the evening meal swallowing whole with water.
- 3 capsules (60 mg) by oral route once daily on an empty stomach,at least 2 hours after the evening meal swallowing whole with water.
- ezetimibe-simvastatin
- Vytorin 10-80
Contraindicated
- ibrutinib
- Imbruvica
- Orap
- pimozide
Severe
Moderate
- AA#9-carnit-dext-cocoa-hrb#128
- Acid Control (ranitidine)
- Acid Reducer (cimetidine)
- Acid Reducer (ranitidine)
- Acid Relief (cimetidine)
- Advicor
- Afinitor
- Afinitor Disperz
- aliskiren-amlodipin-hcthiazide
- aliskiren-amlodipine
- alprazolam
- Alprazolam Intensol
- Altavera (28)
- Altoprev
- Alyacen 1/35 (28)
- Alyacen 7/7/7 (28)
- Alz
- Amethia
- Amethia Lo
- Amethyst
- amiodarone
- amiodarone in dextrose,iso-osm
- amlodipine
- amlodipine-atorvastatin
- amlodipine-benazepril
- amlodipine-olmesartan
- amlodipine-valsartan
- amlodipine-valsartan-hcthiazid
- Amturnide
- Angeliq
- aprepitant
- Apri
- Aranelle (28)
- argin-niac-yohi-gins-ginkgo-hb
- Astagraf Xl
- atorvastatin
- Aubagio
- Aubra
- avanafil
- Aviane
- azithromycin
- Azor
- Azurette (28)
- B6-FA-B12-co Q10-herb no.225
- Balziva (28)
- Beauty & Skin Therapy
- Beyaz
- bicalutamide
- Brevicon (28)
- Briellyn
- Brilinta
- C-Zn-K.ginseng-rose hips-hrb62
- Caduet
- Camila
- Camrese
- Camrese Lo
- Casodex
- Caziant (28)
- Central Vite
- Central-vite Performance
- Chateal
- chlorzoxazone
- cholestyramine (with sugar)
- Cholestyramine Light
- cholestyramine-aspartame
- cilostazol
- cimetidine
- clotrimazole
- Cold & Flu Fighter
- colesevelam
- Colestid
- Colestid Flavored
- colestipol
- Cordarone
- Coumadin
- Covaryx
- Covaryx H.s.
- Cryselle (28)
- Cyclafem 1/35 (28)
- Cyclafem 7/7/7 (28)
- Cyclessa (28)
- cyclosporine
- cyclosporine modified
- D3-red wine-resveratrol-malt
- Daily Multiple
- Daily Multiple For Men 50+
- Dasetta 1/35 (28)
- Dasetta 7/7/7 (28)
- Daysee
- delavirdine
- Depo-provera
- Depo-subq Provera 104
- Deprizine
- desog-e.estradiol/e.estradiol
- Desogen
- desogestrel-ethinyl estradiol
- diet supp#21-calcium phosphate
- drospirenone-e.estradiol-lm.FA
- drospirenone-estradiol
- drospirenone-ethinyl estradiol
- Eemt
- Eemt Hs
- Elinest
- Emend
- Emoquette
- Enpresse
- Enskyce
- Errin
- Estarylla
- estradiol valerate-dienogest
- Estro Support Es
- Estroblend
- estrogens-methyltestosterone
- Estrostep Fe-28
- Estroven Maximum Strength
- Estroven Mood & Memory
- ethynodiol diac-eth estradiol
- etonogestrel
- etonogestrel-ethinyl estradiol
- everolimus
- Exforge
- Exforge Hct
- ezetimibe-atorvastatin
- Falmina (28)
- Femcon Fe
- fluoxetine
- fluvoxamine
- fosaprepitant
- Generess Fe
- Gengraf
- Gianvi (28)
- Gildagia
- Gildess
- Gildess Fe
- Healthy Heart Complex
- Heartburn Relief
- Heartburn Relief (ranitidine)
- Heather
- Hecoria
- Immune Support Complex
- Introvale
- isoniazid
- isoniazid-rifamp-pyrazinamide
- ivacaftor
- Jantoven
- Jencycla
- Jentadueto
- Jolessa
- Jolivette
- Junel 1.5/30 (21)
- Junel 1/20 (21)
- Junel Fe 1.5/30 (28)
- Junel Fe 1/20 (28)
- Kalydeco
- Kariva (28)
- Kelnor 1/35 (28)
- Kurvelo
- L norgest&E estradiol-E estrad
- lapatinib
- Larin 1/20 (21)
- Larin Fe
- Leena 28
- Lessina
- Levonest (28)
- levonorg-eth estrad triphasic
- levonorgestrel
- levonorgestrel-ethinyl estrad
- Levora 0.15/30 (28)
- Levora-28
- linagliptin
- linagliptin-metformin
- Lipitor
- Liptruzet
- Lo Loestrin Fe
- Loestrin 1.5/30 (21)
- Loestrin 1/20 (21)
- Loestrin Fe 1.5/30 (28)
- Loestrin Fe 1/20 (28)
- Lomedia 24 Fe
- Loryna (28)
- Lorzone
- Loseasonique
- Lotrel
- lovastatin
- Low-ogestrel (28)
- Lutera (28)
- Luvox Cr
- Lyza
- Marlissa
- Maximum Daily Green
- medroxyprogesterone
- Megavite
- Megavite Golden Years 55+
- Memory Complex
- Men's 50+ Daily Formula
- Mevacor
- Microgestin 1.5/30 (21)
- Microgestin 1/20 (21)
- Microgestin Fe 1.5/30 (28)
- Microgestin Fe 1/20 (28)
- Minastrin 24 Fe
- Mircette (28)
- Modicon (28)
- Mono-linyah
- Mononessa (28)
- MSM-collag-co Q10-herb no.226
- multivit,Ca,mins-FA-herbal#176
- Multivital Performance
- mv with min-FA-lycopene-ginkgo
- mv,Ca,min-FA-herbal comp #223
- mv,Ca,min-FA-herbal no.157
- mv-FA-D3-K-lycop-lut-herb#220
- mv-iron-FA-Ca-beepoln-hb 101
- mv-iron-min-ginkgo b-ginseng
- mv-mn-FA-herbs190&215-digest#4
- mv-mn-iron-FA-herbal cmplx#190
- mv-mn-lycop-lut-herbal comp219
- My Way
- Myzilra
- Natazia
- Necon 0.5/35 (28)
- Necon 1/35 (28)
- Necon 1/50 (28)
- Necon 10/11 (28)
- Necon 7/7/7 (28)
- Neoral
- Nexplanon
- Next Choice One Dose
- Nexterone
- niacin-lovastatin
- niacin-simvastatin
- nilotinib
- Niravam
- Nor-qd
- Nora-be
- norelgestrom-ethinyl estradiol
- noreth-ethinyl estradiol-iron
- norethin-e.estradiol triphasic
- norethin-eth estrad biphasic
- norethindrone (contraceptive)
- norethindrone ac-eth estradiol
- norethindrone-e.estradiol-iron
- norethindrone-ethin estradiol
- norethindrone-mestranol
- norgestimate-ethinyl estradiol
- norgestrel-ethinyl estradiol
- Norinyl 1+35 (28)
- Norinyl 1+50 (28)
- Nortrel 0.5/35 (28)
- Nortrel 1/35 (21)
- Nortrel 1/35 (28)
- Nortrel 7/7/7 (28)
- Norvasc
- Nuvaring
- Ocella
- Ogestrel (28)
- olanzapine-fluoxetine
- olmesartan-amlodipin-hcthiazid
- One Daily For Men 50+ Advanced
- One Daily Men's 50+
- One Daily Women 50 Plus
- One-a-day Men's 50+ Advantage
- Orsythia
- Ortho Evra
- Ortho Micronor
- Ortho Tri-cyclen (28)
- Ortho Tri-cyclen Lo (28)
- Ortho-cept (28)
- Ortho-cyclen (28)
- Ortho-novum 1/35 (28)
- Ortho-novum 7/7/7 (28)
- Ovcon-35 (28)
- Pacerone
- Parafon Forte Dsc
- pazopanib
- Philith
- Phytomulti
- Pimtrea (28)
- Pirmella
- Plan B One-step
- Pletal
- Portia
- prenatal no.44-iron,car-FA-dha
- prenatal vit#112-folic acid
- Prenate Chewable
- Prenate Mini
- Prevalite
- Previfem
- Prograf
- Pronutrients Fruit-veggie
- Prozac
- Prozac Weekly
- Quartette
- Quasense
- Questran
- Questran Light
- ranitidine HCl
- Reclipsen (28)
- Red Wine Complex
- Red Wine Extract
- Renagel
- Renvela
- Rescriptor
- resve-chrom-grn tea-EGCG-dig#3
- resver-red-bfl-grpsd-pol-C-pom
- resver-wine-bfl-grpsd-pc-C-grp
- Resveratrol Diet
- resveratrol-quercetin
- Rifamate
- rifampin-isoniazid
- Rifater
- Safyral
- Samsca
- Sandimmune
- Sarafem
- Seasonique
- Sentra Pm
- sevelamer carbonate
- sevelamer HCl
- Simcor
- simvastatin
- Spectravite Performance
- Sprintec (28)
- Sronyx
- Stendra
- Super-d3+
- Syeda
- Symbyax
- tacrolimus
- Tagamet Hb
- Tasigna
- Tekamlo
- telmisartan-amlodipine
- teriflunomide
- ticagrelor
- Tilia Fe
- tolvaptan
- Tradjenta
- Tri-estarylla
- Tri-legest Fe
- Tri-linyah
- Tri-norinyl (28)
- Tri-previfem (28)
- Tri-sprintec (28)
- Tribenzor
- Trinessa (28)
- Trivora (28)
- Twynsta
- Tykerb
- Velivet Triphasic Regimen (28)
- Vestura (28)
- Vigraplex
- vinp-hupe-gink-a-cyst-phos-ace
- Viorele (28)
- vit C-St. John wort-elder-hb30
- vit C-vit E-Se-ginkgo biloba
- Votrient
- Vyfemla (28)
- Vytorin 10-10
- Vytorin 10-20
- Vytorin 10-40
- Wal-zan 150
- warfarin
- Welchol
- Wera (28)
- Women's 50+ Daily Formula
- Wymzya Fe
- Xanax
- Xanax Xr
- Yasmin (28)
- Yaz 28
- Zantac
- Zantac Maximum Strength
- Zarah
- Zenchent (28)
- Zenchent Fe
- Zeosa
- zileuton
- Zithromax
- Zithromax Tri-pak
- Zithromax Z-pak
- Zmax
- Zocor
- Zortress
- Zovia 1/35E (28)
- Zovia 1/50E (28)
- Zyflo
- Zyflo Cr
- Drug-induced hepatitis
- Hepatic cirrhosis
- Pregnancy
- Severe hepatic disease
Contraindicated
- Abnormal hepatic function tests
- Alcoholism
- End-stage renal disease
- Hyperbilirubinemia
- Malabsorption states
- Steatosis of liver
Severe
Moderate
- None
JUXTAPID (LOMITAPIDE MESYLATE)
- Homozygous familial hypercholesterolemia
- None
- Acute abdominal pain
- Chest pain
- Diarrhea
- Dyspepsia
- Nausea
- Pharyngitis
- Sore throat
- Vomiting
More Frequent
Severe
Less Severe
- Gastroenteritis
- Increased alanine transaminase
- Increased aspartate transaminase
- Abdominal distension
- Angina
- Back pain
- Constipation
- Dizziness
- Essential fatty acid deficiency
- Fatigue
- Fecal urgency
- Fever
- Flatulence
- Gastroesophageal reflux disease
- Headache disorder
- Influenza
- Nasal congestion
- Palpitations
- Tenesmus
- Vitamin E deficiency
- Weight loss
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Hepatitis
- Severe diarrhea
- Steatosis of liver
Less Severe
- Alopecia
- Myalgias
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Lomitapide
Safety and efficacy not established.
- 1 Day – 18 Years
- Safety and efficacy not established.
Lomitapide
- Severity Level:
X
- Additional Notes: Based on drug pharmacology and animal data, dev tox may occur
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Lomitapide
Insufficient human data available; tumorigenic in rats
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human data available; tumorigenic in rats |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- Lomitapide may rarely cause serious (possibly fatal) liver disease. This medication increases fat in the liver, which may also increase the risk for liver disease. Careful monitoring by your doctor may decrease your risk.<br /><br />Lab and/or medical tests (such as liver function) should be done before starting treatment and while you are taking this medication. Keep all medical and lab appointments. Get medical help right away if you have any symptoms of liver damage, such as nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine.<br /><br /> For patients to receive this medication, all doctors, pharmacists, and patients must agree to, understand, and carefully follow the requirements of the Juxtapid REMS Program. These requirements apply in the United States. If you live in Canada or any other country, consult your doctor and pharmacist for your country's regulations.
Homozygous familial hypercholesterolemia | |
E78.01 | Familial hypercholesterolemia |
0-9 | A-Z |
---|---|
E78.01 | Familial hypercholesterolemia |
Formulary Reference Tool