LOXAPINE (LOXAPINE SUCCINATE)
- Schizophrenia
10 mg capsule
- 2 capsules (20 mg) by oral route 4 times per day
25 mg capsule
- 1 capsule (25 mg) by oral route 3 times per day
5 mg capsule
- 1 capsule (5 mg) by oral route 4 times per day
50 mg capsule
- 1 capsule (50 mg) by oral route 2 times per day
succinate 10 mg capsule
- 2 capsules (20 mg) by oral route 4 times per day
succinate 25 mg capsule
- 1 capsule (25 mg) by oral route 3 times per day
succinate 5 mg capsule
- 1 capsule (5 mg) by oral route 4 times per day
succinate 50 mg capsule
- 1 capsule (50 mg) by oral route 2 times per day
Schizophrenia
- 1 capsule (5 mg) by oral route 4 times per day
- 2 capsules (20 mg) by oral route 4 times per day
- 2 capsules (20 mg) by oral route 2 times per day
- 1 capsule (25 mg) by oral route 3 times per day
- 1 capsule (25 mg) by oral route 4 times per day
- 2 capsules (50 mg) by oral route 2 times per day
- 2 capsules (50 mg) by oral route 3 times per day
- 2 capsules (50 mg) by oral route 4 times per day
- 1 capsule (50 mg) by oral route 2 times per day
- 1 capsule (50 mg) by oral route 3 times per day
- 1 capsule (50 mg) by oral route 4 times per day
- metoclopramide HCl
- Metozolv Odt
- Reglan
Contraindicated
- Apokyn
- apomorphine
- cabergoline
- carbidopa-levodopa
- carbidopa-levodopa-entacapone
- Comtan
- entacapone
- Mirapex
- Mirapex Er
- pramipexole
- Requip
- Requip Xl
- ropinirole
- Sinemet
- Sinemet Cr
- Stalevo 100
- Stalevo 125
- Stalevo 150
- Stalevo 200
- Stalevo 50
- Stalevo 75
Severe
Moderate
- Alagesic Lq
- amobarbital
- Amytal
- Anaspaz
- Aplenzin
- Ascomp With Codeine
- Atropen
- atropine
- belladonna alkaloids-opium
- Belladonna-opium
- Belladonna-phenobarbital
- Bentyl
- benztropine
- Bupap
- Buproban
- bupropion HBr
- bupropion HCl
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- Cantil
- Capacet
- chlordiazepoxide-clidinium
- chlorphen-pseudoeph-bellad alk
- codeine-butalbital-ASA-caff
- Cogentin
- Cuvposa
- dicyclomine
- diphenoxylate-atropine
- Ditropan Xl
- Donnatal
- Duodote
- Ed-spaz
- edrophonium Cl-atropine
- Enlon-plus
- Esgic
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- flavoxate
- Forfivo Xl
- Gelnique
- Glycate
- glycopyrrolate
- Hydrocodone Compound
- hydrocodone-homatropine
- Hydromet
- Hyophen
- hyoscyamine sulfate
- Hyosyne
- Levbid
- Levsin
- Levsin/sl
- Librax (with Clidinium)
- Lomotil
- Luminal
- Margesic
- Marten-tab
- mepenzolate bromide
- methen-hyos-me blue-ba-salicyl
- methen-hyosc-m.blue-sal-naphos
- methen-sod phos-meth blue-hyos
- methscopolamine
- mth-me blue-sod phos-phsal-hyo
- Mysoline
- Nembutal Sodium
- Nulev
- Oscimin
- Oscimin Sl
- Oscimin Sr
- oxybutynin
- oxybutynin chloride
- Oxytrol
- Oxytrol For Women
- Pamine
- Pamine Forte
- pentobarbital sodium
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phosphasal
- pralidoxime-atropine
- primidone
- propantheline
- Prosed/ds (atropine Free)
- Respa-ar
- Robinul
- Robinul Forte
- scopolamine base
- scopolamine HBr
- secobarbital sodium
- Seconal Sodium
- Symax Duotab
- Symax Fastabs
- Symax-sl
- Symax-sr
- Tencon
- Transderm-scop
- trihexyphenidyl
- Tussigon
- Ur N-c
- Urelle
- Uretron D-s
- Uribel
- Urimar-t
- Urin Ds
- Urogesic-blue
- Uryl
- Ustell
- Uta
- Wellbutrin
- Wellbutrin Sr
- Wellbutrin Xl
- Zebutal
- Zyban
- Coma
- Drug-induced CNS depression
- Neuroleptic malignant syndrome
Contraindicated
- Alcoholism
- Carcinoma of breast
- Neutropenic disorder
- Senile dementia
- Tardive dyskinesia
Severe
Moderate
- Glaucoma
- Hyperprolactinemia
- Pigmentary retinopathy
- Seizure disorder
- Severe cardiovascular disease
- Urinary retention
LOXAPINE (LOXAPINE SUCCINATE)
- Schizophrenia
- Akathisia
- Extrapyramidal disease
- Parkinsonism
- Tardive dyskinesia
- Acute confusion
- Drowsy
- Orthostatic hypotension
More Frequent
Severe
Less Severe
- Acquired dystonia
- Allergic dermatitis
- Dysuria
- Hypotension
- Skin rash
- Syncope
- Abnormal sexual function
- Amenorrhea
- Blurred vision
- Constipation
- Decreased sweating
- Dizziness
- Erectile dysfunction
- Facial edema
- Fever
- Galactorrhea not associated with childbirth
- Gynecomastia
- Headache disorder
- Insomnia
- Irregular menstrual periods
- Nasal congestion
- Nausea
- Pruritus of skin
- Skin photosensitivity
- Tachycardia
- Vomiting
- Weight gain
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Accidental fall
- Agranulocytosis
- Hepatitis
- Hepatocellular damage
- Jaundice
- Leukopenia
- Neuroleptic malignant syndrome
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Paralytic ileus
- Seizure disorder
Less Severe
- Alopecia
- Blepharoptosis
- Dyspnea
- Flushing
- Paresthesia
- Polydipsia
- Seborrhea
- Urinary retention
- Weight loss
Contraindicated
None
Severe Precaution
Loxapine
No established safety and efficacy in pediatrics.
- 1 Day – 18 Years
- No established safety and efficacy in pediatrics.
Management or Monitoring Precaution
None
Loxapine
- Severity Level:
C
- Additional Notes: Neonate complications (resp, gi, cns) with exposure in 3rd trimester
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Loxapine
Insufficient human data; manufacturer does not recommend
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human data; manufacturer does not recommend |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Loxapine
Neuro/Psych-Higher risk of tardive dyskinesia in the elderly. Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Increased risk of death in senile dementia. Cardiovascular-May cause orthostatic hypotension at higher doses. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | N | Y | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- There may be a slightly increased risk of serious, possibly fatal side effects (such as heart failure, fast/irregular heartbeat, pneumonia) when this medication is used by older adults with dementia. This medication is not approved for the treatment of dementia-related behavior problems. Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor.
Schizophrenia | |
F20 | Schizophrenia |
F20.0 | Paranoid schizophrenia |
F20.1 | Disorganized schizophrenia |
F20.2 | Catatonic schizophrenia |
F20.3 | Undifferentiated schizophrenia |
F20.5 | Residual schizophrenia |
F20.8 | Other schizophrenia |
F20.81 | Schizophreniform disorder |
F20.89 | Other schizophrenia |
F20.9 | Schizophrenia, unspecified |
0-9 | A-Z |
---|---|
F20 | Schizophrenia |
F20.0 | Paranoid schizophrenia |
F20.1 | Disorganized schizophrenia |
F20.2 | Catatonic schizophrenia |
F20.3 | Undifferentiated schizophrenia |
F20.5 | Residual schizophrenia |
F20.8 | Other schizophrenia |
F20.81 | Schizophreniform disorder |
F20.89 | Other schizophrenia |
F20.9 | Schizophrenia, unspecified |