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DEFERASIROX (deferasirox)
- Chronic iron overload due to repeated blood transfusions
- Chronic iron overload in NTD thalassemia
- Jadenu Tablet
- Exjade Dispersible Tablet
- Deferasirox Tablet
- Deferasirox Dispersible Tablet
- By Indication
180 mg tablet
- 1 tablet (180 mg) by oral route once daily at the same time eachday
360 mg tablet
- 1 tablet (360 mg) by oral route once daily at the same time eachday
90 mg tablet
- 1 tablet (90 mg) by oral route once daily at the same time each day
125 mg dispersible tablet
- 1 tablet (125 mg) by oral route once daily on an empty stomach. Dissolve tablets in water, orange juice or apple juice and swallow.
250 mg dispersible tablet
- 1 tablet (250 mg) by oral route once daily on an empty stomach. Dissolve tablets in water, orange juice or apple juice and swallow.
500 mg dispersible tablet
- 1 tablet (500 mg) by oral route once daily on an empty stomach. Dissolve tablets in water, orange juice or apple juice and swallow.
180 mg tablet
- 1 tablet (180 mg) by oral route once daily at the same time eachday
360 mg tablet
- 1 tablet (360 mg) by oral route once daily at the same time eachday
90 mg tablet
- 1 tablet (90 mg) by oral route once daily at the same time each day
125 mg dispersible tablet
- 1 tablet (125 mg) by oral route once daily on an empty stomach. Dissolve tablets in water, orange juice or apple juice and swallow.
250 mg dispersible tablet
- 1 tablet (250 mg) by oral route once daily on an empty stomach. Dissolve tablets in water, orange juice or apple juice and swallow.
500 mg dispersible tablet
- 1 tablet (500 mg) by oral route once daily on an empty stomach. Dissolve tablets in water, orange juice or apple juice and swallow.
Chronic iron overload due to repeated blood transfusions
- 20 mg/kg by oral route once daily on an empty stomach. Dissolve tablets in water, orange juice or apple juice and swallow.
- 30 mg/kg by oral route once daily on an empty stomach. Dissolve tablets in water, orange juice or apple juice and swallow.
- 10 mg/kg by oral route once daily on an empty stomach. Dissolve tablets in water, orange juice or apple juice and swallow.
- 14 mg/kg by oral route once daily at the same time each day
- 28 mg/kg by oral route once daily at the same time each day
- 7 mg/kg by oral route once daily at the same time each day
- 21 mg/kg by oral route once daily at the same time each day
- 1 tablet (90 mg) by oral route once daily at the same time each day
- 1 tablet (125 mg) by oral route once daily on an empty stomach. Dissolve tablets in water, orange juice or apple juice and swallow.
- 1 tablet (250 mg) by oral route once daily on an empty stomach. Dissolve tablets in water, orange juice or apple juice and swallow.
- 1 tablet (360 mg) by oral route once daily at the same time eachday
- 1 tablet (500 mg) by oral route once daily on an empty stomach. Dissolve tablets in water, orange juice or apple juice and swallow.
Chronic iron overload in NTD thalassemia
- 20 mg/kg by oral route once daily on an empty stomach. Dissolve tablets in water, orange juice or apple juice and swallow.
- 30 mg/kg by oral route once daily on an empty stomach. Dissolve tablets in water, orange juice or apple juice and swallow.
- 10 mg/kg by oral route once daily on an empty stomach. Dissolve tablets in water, orange juice or apple juice and swallow.
- 14 mg/kg by oral route once daily at the same time each day
- 28 mg/kg by oral route once daily at the same time each day
- 7 mg/kg by oral route once daily at the same time each day
- 21 mg/kg by oral route once daily at the same time each day
- 1 tablet (90 mg) by oral route once daily at the same time each day
- 1 tablet (125 mg) by oral route once daily on an empty stomach. Dissolve tablets in water, orange juice or apple juice and swallow.
- 1 tablet (250 mg) by oral route once daily on an empty stomach. Dissolve tablets in water, orange juice or apple juice and swallow.
- 1 tablet (360 mg) by oral route once daily at the same time eachday
- 1 tablet (500 mg) by oral route once daily on an empty stomach. Dissolve tablets in water, orange juice or apple juice and swallow.
- None
Contraindicated
- Acid Gone
- Acid Gone Antacid
- Advanced Antacid-antigas
- Al hyd-Mg tr-alg ac-sod bicarb
- Almacone
- Almacone-2
- alum-mag hydroxide-simeth
- aluminum hydrox-magnesium carb
- aluminum hydroxide gel
- aluminum-magnesium hydroxide
- aminophylline
- Antacid
- Antacid Anti-gas
- Antacid Anti-gas Double Str
- Antacid Extra Strength
- Antacid Extra-strength
- Antacid Ii Plus Simethicone
- Antacid Liquid
- Antacid M
- Antacid Maximum Strength
- Antacid Plus Anti-gas
- Antacid Plus Extra Strength
- Antacid Regular Strength
- Antacid Tablet
- Antacid With Simethicone
- Antacid-antigas
- Antacid-antigas Ii
- Antacid-simethicone
- Antacid-simethicone Ds
- ASA-acetaminophen-caff-buffers
- aspirin, buffered
- Bayer Plus Extra Strength
- Belladonna-phenobarbital
- Carafate
- Cerebyx
- cholestyramine (with sugar)
- Cholestyramine Light
- cholestyramine-aspartame
- colesevelam
- Colestid
- Colestid Flavored
- colestipol
- Comfort Gel
- Comfort Gel Extra Strength
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Donnatal
- Elixophyllin
- Flanax
- Foaming Antacid
- Foaming Antacid Extra Strength
- fosphenytoin
- Gaviscon
- Gaviscon Extra Strength
- Gelusil Antacid & Anti-gas
- Geri-lanta
- Geri-mox Antacid-antigas
- Heartburn Antacid
- isoniazid-rifamp-pyrazinamide
- Kaletra
- kaolin-pectin
- Liquid Antacid
- lopinavir-ritonavir
- Luminal
- Maalox Advanced
- Maalox Maximum Strength
- Mag-al
- Mag-al Plus
- Mag-al Plus Extra Strength
- magaldrate
- magaldrate-simethicone
- Maglox
- magnesium-aluminum-alginic ac
- Masanti Double Strength
- Mi-acid
- Mintox
- Mintox Maximum Strength
- Mintox Plus
- Mysoline
- Norvir
- Norvir Soft Gelatin
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- Prevalite
- primidone
- Questran
- Questran Light
- Ri-gel
- Ri-gel Ii
- Ri-mag
- Ri-mag Plus
- Ri-mox
- Ri-mox Plus
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Riginic
- ritonavir
- Rulox
- sucralfate
- Theo-24
- Theochron
- theophylline
- theophylline in dextrose 5 %
- tizanidine
- Vanquish
- Welchol
- Zanaflex
Severe
Moderate
- Prandimet
- Prandin
- repaglinide
- repaglinide-metformin
- Acute renal failure
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Gastrointestinal hemorrhage
- Hepatic cirrhosis
- Lactating mother
- Severe hepatic disease
- Severe thrombocytopenia
Contraindicated
- Abnormal hepatic function tests
- Cataracts
- Dehydration
- Disease of liver
- Gastrointestinal ulcer
- Hearing loss
- Hyperbilirubinemia
- Kidney disease with likely reduction in GFR
- Malignancy
- Multiple organ failure
- Myelodysplastic syndrome
- Neutropenic disorder
- Ocular hypertension
- Pregnancy
Severe
Moderate
- Anemia
- Proteinuria
DEFERASIROX (deferasirox)
- Chronic iron overload due to repeated blood transfusions
- Chronic iron overload in NTD thalassemia
- Kidney disease with reduction in GFR
- Acute abdominal pain
- Diarrhea
- Nausea
- Pharyngitis
- Proteinuria
- Skin rash
- Vomiting
More Frequent
Severe
Less Severe
- Urticaria
- Upper respiratory infection
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute renal failure
- Agranulocytosis
- Anaphylaxis
- Anemia
- Angioedema
- Biliary calculus
- Cataracts
- DRESS syndrome
- Erythema multiforme
- Fanconi syndrome
- Gastritis
- Gastrointestinal hemorrhage
- Gastrointestinal perforation
- Gastrointestinal ulcer
- Hearing loss
- Hepatic failure
- Hepatitis
- Hyperbilirubinemia
- Hypersensitivity angiitis
- Hypersensitivity drug reaction
- Increased alanine transaminase
- Increased aspartate transaminase
- Interstitial nephritis
- Maculopathy
- Neutropenic disorder
- Ocular hypertension
- Optic neuritis
- Pancreatitis
- Renal failure
- Stevens-johnson syndrome
- Thrombocytopenic disorder
- Toxic epidermal necrolysis
Less Severe
- Alopecia
- Dizziness
- Edema
- Esophagitis
- Fatigue
- Fever
- Hyperkinesis
- Insomnia
- Purpura
- Symptoms of anxiety
Contraindicated
None
Severe Precaution
Deferasirox
Toxicity with impaired or immature renal function. No safety and efficacy established age < 2 years.
- 1 Day – 2 Years
- Toxicity with impaired or immature renal function. No safety and efficacy established age < 2 years.
Management or Monitoring Precaution
Deferasirox
Interrupt for volume depleting illness (vomiting, diarrhea, decreased oral intake) and monitor renal and hepatic function. Monitor auditory and ophthalmic function.
- 2 Years – 18 Years
- Interrupt for volume depleting illness (vomiting, diarrhea, decreased oral intake) and monitor renal and hepatic function. Monitor auditory and ophthalmic function.
Deferasirox
- Severity Level:
D
- Additional Notes: Insufficient human data available.
Contraindicated
Deferasirox
Drug excreted in rat studies, potential for iron depletion in infant.
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Drug excreted in rat studies, potential for iron depletion in infant. |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Deferasirox
General-Elderly have increased risk for adverse effects. Renal-Contraindicated with CrCL<40mL/min. Reduce dose by 50% for CrCL=40-60 mL/min. Hepatic-Risk for worsened hepatic impairment and failure. Monitor LFTs closely. Gastrointestinal-GI bleed risk. Hematologic-Caution in high risk myelodysplastic syndromes due to increased incidence of toxicities.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | N | Y | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- Deferasirox may rarely cause serious (even fatal) kidney disease, liver disease, and stomach/intestinal bleeding (see also Side Effects section). Kidney disease may be more likely to occur in people with kidney problems and in people with serious blood diseases. Liver disease may be more likely to occur in people with liver problems (such as cirrhosis) and in older adults.<br /><br />Stomach/intestinal bleeding may be more likely to occur in older adults with serious blood diseases (including blood cancers). Consult your doctor for more details. Your doctor will monitor you closely while you are taking this medication. Keep all regular medical and laboratory appointments.
| Chronic iron overload due to repeated blood transfusions | |
| E83.111 | Hemochromatosis due to repeated red blood cell transfusions |
| Chronic iron overload in NTD thalassemia | |
| E83.118 | Other hemochromatosis |
| 0-9 | A-Z |
|---|---|
| E83.111 | Hemochromatosis due to repeated red blood cell transfusions |
| E83.118 | Other hemochromatosis |
Formulary Reference Tool