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ATENOLOL-CHLORTHALIDONE (atenolol/chlorthalidone)
- Hypertension
- Tenoretic 50 Tablet
- Tenoretic 100 Tablet
- Atenolol-chlorthalidone Tablet
- Atenolol-chlorthalidone Tab
- By Indication
50 mg-25 mg tablet
- 1 tablet by oral route once daily
100 mg-25 mg tablet
- 1 tablet by oral route once daily
atenolol 100 mg-chlorthalidone 25 mg tablet
- 1 tablet by oral route once daily
atenolol 50 mg-chlorthalidone 25 mg tablet
- 1 tablet by oral route once daily
atenolol 100 mg-chlorthalidone 25 mg tablet
- 1 tablet by oral route once daily
atenolol 50 mg-chlorthalidone 25 mg tablet
- 1 tablet by oral route once daily
Hypertension
- 1 tablet by oral route once daily
- 2 tablets by oral route once daily
- dofetilide
- Tikosyn
Contraindicated
- Adrenaclick
- Adrenalin
- Asthmanefrin Refill
- Asthmanefrin Starter Kit
- Auvi-q
- Bronchial Mist
- Bronchial Mist Refill
- bupivacaine-epinephrine
- bupivacaine-epinephrine (PF)
- bupivacaine-epinephrine bitart
- Catapres
- Catapres-tts-1
- Catapres-tts-2
- Catapres-tts-3
- clonidine
- clonidine (PF)
- clonidine-chlorthalidone
- Clorpres
- Corlopam
- Curad Enema
- Disposable Enema
- Duraclon (pf)
- Enema
- Enema Disposable
- epinephrine
- epinephrine (PF)
- epinephrine base (refill)
- epinephrine HCl
- Epipen
- Epipen 2-pak
- Epipen Jr
- Epipen Jr 2-pak
- fenoldopam
- fingolimod
- Fleet Enema
- Fleet Enema Extra
- Fleet Pediatric
- Gilenya
- Kapvay
- lidocaine-epinephrine
- lidocaine-epinephrine (PF)
- lidocaine-epinephrine bit
- lithium carbonate
- lithium citrate
- Lithobid
- Marcaine-epinephrine
- Marcaine-epinephrine (pf)
- Oral Saline Laxative
- Osmoprep
- Phosphate Laxative
- Preparation Cleansing
- racepinephrine
- Ready-to-use Enema
- Reclast
- S2 Racepinephrine
- Sensorcaine-mpf/epinephrine
- Sensorcaine/epinephrine
- sod phos mono-sod phos dibasic
- sodium phosphates
- Xylocaine-epinephrine
- Xylocaine-mpf/epinephrine
- zoledronic acid
- zoledronic acid-mannitol-water
- Zometa
Severe
Moderate
- acarbose
- Adalat Cc
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- Afeditab Cr
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- Amaryl
- Anaprox
- Anaprox Ds
- Ansaid
- Apidra
- Apidra Solostar
- Calan
- Calan Sr
- Caldolor
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- Child Ibuprofen
- Children's Advil
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- cholestyramine (with sugar)
- Cholestyramine Light
- cholestyramine-aspartame
- Cold & Sinus Pain Relief
- Cold-sinus Relief
- Colestid
- Colestid Flavored
- colestipol
- dextromethorphan-quinidine
- Diabeta
- diazoxide
- Digox
- digoxin
- Dilacor Xr
- Dilt-xr
- diltiazem HCl
- Duetact
- Duexis
- Ec-naprosyn
- Feldene
- Flanax
- flurbiprofen
- glimepiride
- glipizide
- glipizide-metformin
- Glucotrol
- Glucotrol Xl
- Glucovance
- glyburide
- glyburide micronized
- glyburide-metformin
- Glynase
- Glyset
- Humalog
- Humalog Kwikpen
- Humalog Mix 50-50
- Humalog Mix 50-50 Kwikpen
- Humalog Mix 75-25
- Humalog Mix 75-25 Kwikpen
- Humulin 70/30
- Humulin N
- Humulin N Kwikpen
- Humulin R
- Humulin R U-500 "Concentrated"
- hydrocodone-ibuprofen
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-oxycodone
- ibuprofen-phenylephrine HCl
- Indocin
- indomethacin
- indomethacin sodium
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- insulin asp prt-insulin aspart
- insulin aspart
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin lispro
- insulin lispro protam-lispro
- insulin NPH and regular human
- insulin regular hum U-500 conc
- insulin regular human
- Lanoxin
- Lanoxin Pediatric
- Lantus
- Lantus Solostar
- Levemir
- Levemir Flexpen
- Matzim La
- Medi-profen
- Mediproxen
- mefloquine
- meloxicam
- Midol (naproxen)
- miglitol
- Minipress
- Mobic
- Motrin Ib
- Motrin Pm
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- nateglinide
- Neoprofen (ibuprofen Lysn)(pf)
- Nifedical Xl
- nifedipine
- Novolin 70/30
- Novolin N
- Novolin R
- Novolog
- Novolog Flexpen
- Novolog Mix 70-30
- Novolog Mix 70-30 Flexpen
- Novolog Penfill
- NPH insulin human recomb
- Nuedexta
- pioglitazone-glimepiride
- piroxicam
- prazosin
- Precose
- Prevalite
- Procardia
- Procardia Xl
- Proglycem
- Provil
- pseudoephedrine-ibuprofen
- Questran
- Questran Light
- quinidine gluconate
- quinidine sulfate
- Reprexain
- Sinus & Cold-d
- Starlix
- sulindac
- Tarka
- Taztia Xt
- Tiazac
- tolazamide
- tolbutamide
- trandolapril-verapamil
- verapamil
- Verelan
- Verelan Pm
- Vicoprofen
- Vimovo
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- Acute decompensated HF requiring IV inotropic therapy
- Anuria
- Cardiogenic shock
- Complete atrioventricular block
- Lactating mother
- Pregnancy
- Second degree atrioventricular heart block
Contraindicated
- Kidney disease with reduction in GFR
- Oliguria
- Pregnancy
- Severe renal impairment
- Sinus bradycardia
Severe
Moderate
- Abnormal hepatic function tests
- Asthma
- Depression
- Gout
- Hypercalcemia
- Hypercholesterolemia
- Hyperuricemia
- Hypochloremic alkalosis
- Hypokalemia
- Hypomagnesemia
- Hyponatremia
- Psoriasis
- Raynaud's phenomenon
- Severe chronic obstructive pulmonary disease
- Sympathectomy
- Type 1 diabetes mellitus
- Type 2 diabetes mellitus
ATENOLOL-CHLORTHALIDONE (atenolol/chlorthalidone)
- Hypertension
- Depression
- Dizziness
- Hypochloremic alkalosis
- Hypokalemia
- Hyponatremia
- Hypotension
- Abnormal sexual function
- Fatigue
More Frequent
Severe
Less Severe
- Bradycardia
- Bronchospastic pulmonary disease
- Chronic heart failure
- Hyperglycemia
- Hypomagnesemia
- Hypotension
- Kidney disease with reduction in GFR
- Peripheral vasoconstriction
- Abdominal pain with cramps
- Abnormal sexual function
- Anorexia
- Diarrhea
- Dizziness
- Dream disorder
- Drowsy
- Dyspnea
- Fatigue
- Lethargy
- Nausea
- Orthostatic hypotension
- Vertigo
- Vomiting
- Wheezing
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute confusion
- Acute pancreatitis
- Agranulocytosis
- Anaphylaxis
- Aplastic anemia
- Cardiac arrhythmia
- Erythema multiforme
- Exfoliative dermatitis
- Gout
- Hallucinations
- Hemolytic anemia
- Hepatitis
- Hypercalcemia
- Hyperparathyroidism
- Hypersensitivity angiitis
- Hyperuricemia
- Interstitial nephritis
- Interstitial pneumonitis
- Jaundice
- Leukopenia
- Lupus-like syndrome
- Myopia
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Orthostatic hypotension
- Peyronie's disease
- Psoriasiform eruption
- Purpura
- Secondary angle-closure glaucoma
- Sick sinus syndrome
- Squamous cell carcinoma of skin
- Stevens-johnson syndrome
- Systemic lupus erythematosus
- Thrombocytopenic disorder
- Toxic epidermal necrolysis
- Vasculitis
Less Severe
- Abnormal hepatic function tests
- Alopecia
- Basal cell carcinoma of skin
- Blurred vision
- Constipation
- Dry eye
- Erectile dysfunction
- Fever
- Gastrointestinal irritation
- General weakness
- Headache disorder
- Hypercholesterolemia
- Hypertriglyceridemia
- Muscle spasm
- Nervousness
- Paresthesia
- Sialoadenitis
- Skin rash
- Urticaria
- Vertigo
- Xanthopsia
- Xerostomia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Atenolol
Safety and efficacy not established. Dosing guidelines available for children.
No safety and efficacy data in children.
- 1 Day – 18 Years
- Safety and efficacy not established. Dosing guidelines available for children.
- 1 Day – 364 Days
- Safety and efficacy not established. Dosing guidelines available for children.
Chlorthalidone
Safety and efficacy not established. Dosing guidelines available for children.
No safety and efficacy data in children.
- 1 Day – 18 Years
- No safety and efficacy data in children.
- 1 Day – 364 Days
- No safety and efficacy data in children.
Atenolol
- Severity Level:
1
- Additional Notes: Reports of intrauterine growth retardation
Chlorthalidone
- Severity Level:
D
- Additional Notes: Avoid as first line treatment for hypertension during pregnancy
Contraindicated
Chlorthalidone
Mfg does not rec, minimal amnts may be excreted; may suppress lactation
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Excreted | Not known; no or inclusive data | Mfg does not rec, minimal amnts may be excreted; may suppress lactation |
Precaution Exists
Atenolol
Monitor for bradycardia & hypotension; 1 case of bradycardia in neonate
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Drug shown to have adverse effect | Monitor for bradycardia & hypotension; 1 case of bradycardia in neonate |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Atenolol
Cardiovascular-Minimize dose to decrease dizziness and falls. Renal-Renally eliminated; use caution with starting dose and dose escalation. When used for hypertension, older adults may require an initial dose of 25 mg/day.
General-More likely to develop hypokalemia, hypomagnesemia, or hyponatremia. Cardiovascular-Elderly are more sensitive to blood pressure changes. Renal-Less effective in severe renal impairment. Endocrine-May exacerbate SIADH.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | N | N | N |
BEERS: N HEDIS: N STOPP: Y
Chlorthalidone
Cardiovascular-Minimize dose to decrease dizziness and falls. Renal-Renally eliminated; use caution with starting dose and dose escalation. When used for hypertension, older adults may require an initial dose of 25 mg/day.
General-More likely to develop hypokalemia, hypomagnesemia, or hyponatremia. Cardiovascular-Elderly are more sensitive to blood pressure changes. Renal-Less effective in severe renal impairment. Endocrine-May exacerbate SIADH.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | N | N | Y |
BEERS: Y HEDIS: N STOPP: Y
No Known Risk
None
- None
| Hypertension | |
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
| 0-9 | A-Z |
|---|---|
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
Formulary Reference Tool