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COLISTIMETHATE (colistin (as colistimethate sodium))
- E. coli infection
- Enterobacter infection
- Klebsiella infection
- Pseudomonas aeruginosa infection
- Coly-mycin M Parenteral Solution For Injection
- Colistin (colistimethate Sodium) Solution For Injection
- By Indication
150 mg solution for injection
- Dosage information is not available
colistin ( sodium) 150 mg solution for injection
- Dosage information is not available
colistin () 150 mg solution for injection
- Dosage information is not available
E. coli infection
- Inject 1.25 mg/kg by intravenous route 2 times per day
- Inject 2.5 mg/kg by intravenous route 2 times per day
- Inject 1.25 mg/kg by intravenous route every 12 hours
- Inject 2.5 mg/kg by intravenous route every 12 hours
- Inject 1.25 mg/kg by intramuscular route 2 times per day
- Inject 2.5 mg/kg by intramuscular route 2 times per day
- Inject 1.25 mg/kg by intramuscular route every 12 hours
- Inject 2.5 mg/kg by intramuscular route every 12 hours
- Inject 0.625 mg/kg by intramuscular route 4 times per day
- Inject 1.25 mg/kg by intramuscular route 4 times per day
- Inject 0.625 mg/kg by intramuscular route every 6 hours
- Inject 1.25 mg/kg by intramuscular route every 6 hours
Enterobacter infection
- Inject 1.25 mg/kg by intravenous route 2 times per day
- Inject 2.5 mg/kg by intravenous route 2 times per day
- Inject 1.25 mg/kg by intravenous route every 12 hours
- Inject 2.5 mg/kg by intravenous route every 12 hours
- Inject 1.25 mg/kg by intramuscular route 2 times per day
- Inject 2.5 mg/kg by intramuscular route 2 times per day
- Inject 1.25 mg/kg by intramuscular route every 12 hours
- Inject 2.5 mg/kg by intramuscular route every 12 hours
- Inject 0.625 mg/kg by intramuscular route 4 times per day
- Inject 1.25 mg/kg by intramuscular route 4 times per day
- Inject 0.625 mg/kg by intramuscular route every 6 hours
- Inject 1.25 mg/kg by intramuscular route every 6 hours
Klebsiella infection
- Inject 1.25 mg/kg by intravenous route 2 times per day
- Inject 2.5 mg/kg by intravenous route 2 times per day
- Inject 1.25 mg/kg by intravenous route every 12 hours
- Inject 2.5 mg/kg by intravenous route every 12 hours
- Inject 1.25 mg/kg by intramuscular route 2 times per day
- Inject 2.5 mg/kg by intramuscular route 2 times per day
- Inject 1.25 mg/kg by intramuscular route every 12 hours
- Inject 2.5 mg/kg by intramuscular route every 12 hours
- Inject 0.625 mg/kg by intramuscular route 4 times per day
- Inject 1.25 mg/kg by intramuscular route 4 times per day
- Inject 0.625 mg/kg by intramuscular route every 6 hours
- Inject 1.25 mg/kg by intramuscular route every 6 hours
Pseudomonas aeruginosa infection
- Inject 1.25 mg/kg by intravenous route 2 times per day
- Inject 2.5 mg/kg by intravenous route 2 times per day
- Inject 1.25 mg/kg by intravenous route every 12 hours
- Inject 2.5 mg/kg by intravenous route every 12 hours
- Inject 1.25 mg/kg by intramuscular route 2 times per day
- Inject 2.5 mg/kg by intramuscular route 2 times per day
- Inject 1.25 mg/kg by intramuscular route every 12 hours
- Inject 2.5 mg/kg by intramuscular route every 12 hours
- Inject 0.625 mg/kg by intramuscular route 4 times per day
- Inject 1.25 mg/kg by intramuscular route 4 times per day
- Inject 0.625 mg/kg by intramuscular route every 6 hours
- Inject 1.25 mg/kg by intramuscular route every 6 hours
- typhoid vaccine
- Vivotif Berna Vaccine
Contraindicated
- None
Severe
Moderate
- abobotulinumtoxinA
- Anectine
- atracurium
- Botox
- Botox Cosmetic
- cisatracurium
- Dysport
- incobotulinumtoxinA
- Myobloc
- Nimbex
- onabotulinumtoxinA
- pancuronium
- Quelicin
- rimabotulinumtoxinB
- rocuronium
- succinylcholine chloride
- vecuronium bromide
- Xeomin
- Zemuron
- None
Contraindicated
- Clostridium difficile infection
- Kidney disease with reduction in GFR
- Myasthenia gravis
Severe
Moderate
- Neuromuscular blockade
COLISTIMETHATE (colistin (as colistimethate sodium))
- E. coli infection
- Enterobacter infection
- Klebsiella infection
- Pseudomonas aeruginosa infection
- None
- Vertigo
More Frequent
Severe
Less Severe
- Paresthesia
- Dizziness
- Fever
- Gastrointestinal irritation
- Pruritus of skin
- Skin rash
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute respiratory distress syndrome
- Anaphylaxis
- Apnea
- Clostridium difficile infection
- Nephrotoxicity
- Neuromuscular blockade
- Respiration changes
- Seizure disorder
- Slurred speech
- Urticaria
Less Severe
- Oliguria
Contraindicated
None
Severe Precaution
Colistimethate
Monitor renal function to minimize toxicity. Infants and young children unable to report report subjective signs of neurotoxicity.
- 1 Day – 364 Days
- Monitor renal function to minimize toxicity. Infants and young children unable to report report subjective signs of neurotoxicity.
Management or Monitoring Precaution
None
Colistimethate Sodium
- Severity Level:
C
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Colistimethate Sodium
May modify bowel flora of infant
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | May modify bowel flora of infant |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Colistimethate
Renal-Caution with decreased renal function. Increased risk of neurologic side effects. Dose adjust for CLCr< 80 mL/minute.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | N | Y | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| E. coli infection | |
| A04.0 | Enteropathogenic escherichia coli infection |
| A04.1 | Enterotoxigenic escherichia coli infection |
| A04.2 | Enteroinvasive escherichia coli infection |
| A04.3 | Enterohemorrhagic escherichia coli infection |
| A04.4 | Other intestinal escherichia coli infections |
| A41.51 | Sepsis due to escherichia coli [e. coli] |
| B96.2 | Escherichia coli [e. coli ] as the cause of diseases classified elsewhere |
| B96.20 | Unspecified escherichia coli [e. coli] as the cause of diseases classified elsewhere |
| B96.21 | Shiga toxin-producing escherichia coli [e. coli] [STEc] o157 as the cause of diseases classified elsewhere |
| B96.22 | Other specified shiga toxin-producing escherichia coli [e. coli] [STEc] as the cause of diseases classified elsewhere |
| B96.23 | Unspecified shiga toxin-producing escherichia coli [e. coli] [STEc] as the cause of diseases classified elsewhere |
| B96.29 | Other escherichia coli [e. coli] as the cause of diseases classified elsewhere |
| Enterobacter infection | |
| B96.89 | Other specified bacterial agents as the cause of diseases classified elsewhere |
| Klebsiella infection | |
| B96.1 | Klebsiella pneumoniae [k. pneumoniae] as the cause of diseases classified elsewhere |
| J15.0 | Pneumonia due to klebsiella pneumoniae |
| Pseudomonas aeruginosa infection | |
| A41.52 | Sepsis due to pseudomonas |
| B96.5 | Pseudomonas (aeruginosa) (mallei) (pseudomallei) as the cause of diseases classified elsewhere |
| J15.1 | Pneumonia due to pseudomonas |
| P23.5 | Congenital pneumonia due to pseudomonas |
| 0-9 | A-Z |
|---|---|
| A04.0 | Enteropathogenic escherichia coli infection |
| A04.1 | Enterotoxigenic escherichia coli infection |
| A04.2 | Enteroinvasive escherichia coli infection |
| A04.3 | Enterohemorrhagic escherichia coli infection |
| A04.4 | Other intestinal escherichia coli infections |
| A41.51 | Sepsis due to escherichia coli [e. coli] |
| A41.52 | Sepsis due to pseudomonas |
| B96.1 | Klebsiella pneumoniae [k. pneumoniae] as the cause of diseases classified elsewhere |
| B96.2 | Escherichia coli [e. coli ] as the cause of diseases classified elsewhere |
| B96.20 | Unspecified escherichia coli [e. coli] as the cause of diseases classified elsewhere |
| B96.21 | Shiga toxin-producing escherichia coli [e. coli] [STEc] o157 as the cause of diseases classified elsewhere |
| B96.22 | Other specified shiga toxin-producing escherichia coli [e. coli] [STEc] as the cause of diseases classified elsewhere |
| B96.23 | Unspecified shiga toxin-producing escherichia coli [e. coli] [STEc] as the cause of diseases classified elsewhere |
| B96.29 | Other escherichia coli [e. coli] as the cause of diseases classified elsewhere |
| B96.5 | Pseudomonas (aeruginosa) (mallei) (pseudomallei) as the cause of diseases classified elsewhere |
| B96.89 | Other specified bacterial agents as the cause of diseases classified elsewhere |
| J15.0 | Pneumonia due to klebsiella pneumoniae |
| J15.1 | Pneumonia due to pseudomonas |
| P23.5 | Congenital pneumonia due to pseudomonas |
Formulary Reference Tool