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TORISEL (TEMSIROLIMUS)
- Renal cell carcinoma
30 mg/3 mL (10 mg/mL) (first dilution) intravenous solution
- Infuse 25 mg over 30-60 minute(s) by intravenous route once weekly
30 mg/3 mL (10 mg/mL) (first dilution) intravenous soln
- Infuse 25 mg over 30-60 minute(s) by intravenous route once weekly
Renal cell carcinoma
- Infuse 25 mg over 30-60 minute(s) by intravenous route once weekly
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- 1-day
- 3 Day Vaginal
- 3-day Vaginal
- Alagesic Lq
- amobarbital
- amoxicil-clarithromy-lansopraz
- Amytal
- Aptivus
- Ascomp With Codeine
- Astagraf Xl
- atazanavir
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- boceprevir
- Bupap
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- butoconazole nitrate
- calcium-mag-B complex-D3-hrb61
- Capacet
- carbamazepine
- Carbatrol
- Cerebyx
- clarithromycin
- clotrimazole
- Clotrimazole 3 Day
- Clotrimazole-3
- Clotrimazole-7
- clozapine
- Clozaril
- codeine-butalbital-ASA-caff
- Cold & Flu Fighter
- Crixivan
- darunavir
- deferiprone
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Diflucan
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Donnatal
- Epitol
- Equetro
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- Esgic
- ethotoin
- Fatigue Relief Complex
- Fazaclo
- Ferriprox
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fosamprenavir
- fosphenytoin
- Gynazole-1
- Gyne-lotrimin
- Gyne-lotrimin 7
- Hecoria
- Incivek
- indinavir
- Invirase
- isoniazid-rifamp-pyrazinamide
- itraconazole
- Kaletra
- Ketek
- ketoconazole
- Lexiva
- lopinavir-ritonavir
- Luminal
- Margesic
- Marten-tab
- miconazole
- Miconazole 7
- miconazole nitrate
- Miconazole-3
- Miconazole-3 Prefil,cream,wipe
- miconazole-skin clnsr17
- Monistat 1 Combo Pack
- Monistat 3
- Monistat 7
- Monistat 7 Cream, Appl, Wipes
- Mycobutin
- Mysoline
- nafcillin
- nafcillin in dextrose iso-osm
- nefazodone
- nelfinavir
- Nembutal Sodium
- Norvir
- Norvir Soft Gelatin
- Noxafil
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Onmel
- Oravig
- Peganone
- pentobarbital sodium
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- posaconazole
- Prevpac
- Prezista
- Priftin
- primidone
- Prograf
- Reyataz
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- rifapentine
- Rifater
- ritonavir
- saquinavir mesylate
- secobarbital sodium
- Seconal Sodium
- Sporanox
- Sporanox Pulsepak
- St. John's wort
- tacrolimus
- Tegretol
- Tegretol Xr
- telaprevir
- telithromycin
- Tencon
- tioconazole
- Tioconazole-1
- tipranavir
- Vagistat-1
- Vagistat-3
- Versacloz
- Vfend
- Vfend Iv
- Victrelis
- Viracept
- vit C-St. John wort-elder-hb30
- voriconazole
- Women's Complex
- Zebutal
Severe
Moderate
- Calan
- Calan Sr
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- cyclosporine
- cyclosporine modified
- Dilacor Xr
- Dilt-xr
- diltiazem HCl
- Gengraf
- Matzim La
- Neoral
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- Sandimmune
- Tarka
- Taztia Xt
- Tiazac
- trandolapril-verapamil
- verapamil
- Verelan
- Verelan Pm
- Hyperbilirubinemia
- Lactating mother
Contraindicated
- Cerebrovascular accident
- Disease of liver
- Gastrointestinal perforation
- Interstitial pneumonitis
- Kidney disease with reduction in GFR
- Pregnancy
- Severe infection
Severe
Moderate
- Cerebral metastases
- Diabetes mellitus
- Hyperlipidemia
- Impaired wound healing
- Invasive surgical procedure
- Malignant brain neoplasm
- Perioperative care
TORISEL (TEMSIROLIMUS)
- Renal cell carcinoma
- Abnormal hepatic function tests
- Anaphylaxis
- Anemia
- Chest pain
- Dyspnea
- Edema
- Fever
- Hyperglycemia
- Hyperlipidemia
- Hypertension
- Hypertriglyceridemia
- Hypokalemia
- Hypophosphatemia
- Immunosuppression
- Infection
- Leukopenia
- Lymphopenia
- Neutropenic disorder
- Stomatitis
- Thrombocytopenic disorder
- Upper respiratory infection
- Urinary tract infection
- Abdominal pain with cramps
- Acne vulgaris
- Anorexia
- Arthralgias
- Back pain
- Chills
- Constipation
- Cough
- Diarrhea
- Dry skin
- Dysgeusia
- Flushing
- General weakness
- Headache disorder
- Insomnia
- Nausea
- Pain
- Pharyngitis
- Pruritus of skin
- Rhinitis
- Skin rash
- Vomiting
- Weight loss
More Frequent
Severe
Less Severe
- Depression
- Diabetes mellitus
- Gastrointestinal hemorrhage
- Interstitial lung disease
- Pleural effusions
- Pneumonia
- Thrombophlebitis
- Venous thrombosis
- Conjunctivitis
- Epistaxis
- Impaired wound healing
- Myalgias
- Nail disorders
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute renal failure
- Angioedema
- Apnea
- Biliary calculus
- Cholecystitis
- Hypersensitivity drug reaction
- Hypotension
- Intestinal perforation
- Intracerebral hemorrhage
- Nephrotic syndrome
- Pancreatitis
- Pericardial effusion
- Pneumocystis jirovecii pneumonia
- Rectal bleeding
- Rhabdomyolysis
- Seizure disorder
- Sepsis
- Stevens-johnson syndrome
Less Severe
- Extravasation injury
- Injection site sequelae
- Proteinuria
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Temsirolimus
Limited data for advanced/refractory solid tumors. Risks of thrombocytopenia, infection, fatigue, leukopenia, anemia, hyperlipidemia.
- 1 Day – 18 Years
- Limited data for advanced/refractory solid tumors. Risks of thrombocytopenia, infection, fatigue, leukopenia, anemia, hyperlipidemia.
Temsirolimus
- Severity Level:
D
- Additional Notes: Based on drug pharmacology developmental toxicity is possible.
Contraindicated
Temsirolimus
Insuff data avail, but concern for severe adverse effects in infant.
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Insuff data avail, but concern for severe adverse effects in infant. |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Temsirolimus
General-May be at increased risk for diarrhea, edema and pneumonia adverse events.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | N | N | Y | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Renal cell carcinoma | |
| C64 | Malignant neoplasm of kidney, except renal pelvis |
| C64.1 | Malignant neoplasm of right kidney, except renal pelvis |
| C64.2 | Malignant neoplasm of left kidney, except renal pelvis |
| C64.9 | Malignant neoplasm of unspecified kidney, except renal pelvis |
| 0-9 | A-Z |
|---|---|
| C64 | Malignant neoplasm of kidney, except renal pelvis |
| C64.1 | Malignant neoplasm of right kidney, except renal pelvis |
| C64.2 | Malignant neoplasm of left kidney, except renal pelvis |
| C64.9 | Malignant neoplasm of unspecified kidney, except renal pelvis |
Formulary Reference Tool