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ROMIDEPSIN (romidepsin)
- Cutaneous t-cell lymphoma
- Peripheral t-cell lymphoma
10 mg/2 mL intravenous solution
- Dosage information is not available
10 mg/2 mL intravenous solution
- Dosage information is not available
Cutaneous t-cell lymphoma
- Infuse 14 mg/m2 over 4 hour(s) by intravenous route on days 1, 8 and 15 of a 28 day cycle
- Infuse 10 mg/m2 over 4 hour(s) by intravenous route on days 1, 8 and 15 of a 28 day cycle
- Infuse 14 mg/m2 over 4 hour(s) by intravenous route on day 1 of a 28 day cycle
- Infuse 10 mg/m2 over 4 hour(s) by intravenous route on day 1 of a 28 day cycle
- Infuse 14 mg/m2 over 4 hour(s) by intravenous route on day 8 of a 28 day cycle
- Infuse 10 mg/m2 over 4 hour(s) by intravenous route on day 8 of a 28 day cycle
- Infuse 14 mg/m2 over 4 hour(s) by intravenous route on day 15 of a 28Day cycle
- Infuse 10 mg/m2 over 4 hour(s) by intravenous route on day 15 of a 28Day cycle
Peripheral t-cell lymphoma
- Infuse 14 mg/m2 over 4 hour(s) by intravenous route on days 1, 8 and 15 of a 28 day cycle
- Infuse 10 mg/m2 over 4 hour(s) by intravenous route on days 1, 8 and 15 of a 28 day cycle
- Infuse 14 mg/m2 over 4 hour(s) by intravenous route on day 1 of a 28 day cycle
- Infuse 10 mg/m2 over 4 hour(s) by intravenous route on day 1 of a 28 day cycle
- Infuse 14 mg/m2 over 4 hour(s) by intravenous route on day 8 of a 28 day cycle
- Infuse 10 mg/m2 over 4 hour(s) by intravenous route on day 8 of a 28 day cycle
- Infuse 14 mg/m2 over 4 hour(s) by intravenous route on day 15 of a 28Day cycle
- Infuse 10 mg/m2 over 4 hour(s) by intravenous route on day 15 of a 28Day cycle
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- amiodarone
- amiodarone in dextrose,iso-osm
- artemether-lumefantrine
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- calcium-mag-B complex-D3-hrb61
- carbamazepine
- Carbatrol
- Cerebyx
- clozapine
- Clozaril
- Coartem
- Cold & Flu Fighter
- Cordarone
- Coumadin
- deferiprone
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- disopyramide
- Donnatal
- dronedarone
- droperidol
- enzalutamide
- Epitol
- Equetro
- Fatigue Relief Complex
- Fazaclo
- Ferriprox
- fosphenytoin
- Geodon
- isoniazid-rifamp-pyrazinamide
- Jantoven
- Luminal
- Multaq
- Mycobutin
- Mysoline
- Nexterone
- Norpace
- Norpace Cr
- Orap
- Pacerone
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- pimozide
- Priftin
- primidone
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- rifapentine
- Rifater
- St. John's wort
- Tegretol
- Tegretol Xr
- Versacloz
- vit C-St. John wort-elder-hb30
- vorinostat
- warfarin
- Women's Complex
- Xtandi
- ziprasidone HCl
- ziprasidone mesylate
- Zolinza
Severe
Moderate
- Ablavar
- Advair Diskus
- Advair Hfa
- alfuzosin
- Aloxi
- amantadine HCl
- amoxicil-clarithromy-lansopraz
- Anzemet
- Apokyn
- apomorphine
- arsenic trioxide
- asenapine
- Astagraf Xl
- atazanavir
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- azithromycin
- bedaquiline
- Betapace
- Betapace Af
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- boceprevir
- budesonide-formoterol
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- chloroquine phosphate
- chlorpromazine
- clarithromycin
- Complera
- conivaptan in 5 % dextrose
- Corvert
- Crixivan
- crizotinib
- dasatinib
- Diskets
- dofetilide
- dolasetron
- Dolophine
- Dulera
- Edurant
- Effexor Xr
- elvitegr-cobicist-emtric-tenof
- emtricitab-rilpivirine-tenofov
- Eovist
- eribulin
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- ezogabine
- Fareston
- felbamate
- Felbatol
- flecainide
- fluticasone-salmeterol
- Foradil Aerolizer
- formoterol fumarate
- foscarnet
- Foscavir
- gadofosveset trisodium
- gadoxetate
- granisetron
- granisetron (PF)
- Granisol
- Halaven
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Hecoria
- ibutilide fumarate
- Incivek
- indapamide
- indinavir
- Invega
- Invega Sustenna
- Invirase
- isradipine
- itraconazole
- Kaletra
- Ketek
- ketoconazole
- lapatinib
- Levaquin
- Levaquin In 5 % Dextrose
- Levitra
- levofloxacin
- levofloxacin in D5W
- lithium carbonate
- lithium citrate
- Lithobid
- lopinavir-ritonavir
- methadone
- Methadone Intensol
- Methadose
- moexipril
- moexipril-hydrochlorothiazide
- mometasone-formoterol
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Nebupent
- nefazodone
- nelfinavir
- Nexavar
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- nilotinib
- norfloxacin
- Noroxin
- Norvir
- Norvir Soft Gelatin
- Noxafil
- octreotide acetate
- ofloxacin
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- Onmel
- paliperidone
- paliperidone palmitate
- palonosetron
- pasireotide
- pazopanib
- Pentam
- pentamidine
- Perforomist
- posaconazole
- Potiga
- Prevpac
- procainamide
- Prograf
- propafenone
- Qualaquin
- quetiapine
- quinine sulfate
- Reyataz
- rilpivirine
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- ritonavir
- Rythmol
- salmeterol
- Sancuso
- Sandostatin
- Sandostatin Lar Depot
- Saphris
- Saphris (black Cherry)
- saquinavir mesylate
- Serevent Diskus
- Seroquel
- Seroquel Xr
- Signifor
- Sirturo
- Soltamox
- sorafenib
- Sorine
- sotalol
- Sotalol Af
- Sporanox
- Sporanox Pulsepak
- Sprycel
- Stribild
- sunitinib
- Sutent
- Symbicort
- tacrolimus
- tamoxifen
- Tasigna
- telaprevir
- telavancin
- telithromycin
- tetrabenazine
- thioridazine
- Tikosyn
- tizanidine
- toremifene
- Trisenox
- Tykerb
- Uniretic
- Univasc
- Uroxatral
- Vaprisol
- vardenafil
- vemurafenib
- venlafaxine
- Vfend
- Vfend Iv
- Vibativ
- Victrelis
- Viracept
- voriconazole
- Votrient
- Xalkori
- Xenazine
- Zanaflex
- Zelboraf
- Zithromax
- Zithromax Tri-pak
- Zithromax Z-pak
- Zmax
- Zofran
- Zofran Odt
- Zuplenz
- Lactating mother
Contraindicated
- Anemia
- Cardiac arrhythmia
- Congenital long QT syndrome
- Hypokalemia
- Hypomagnesemia
- Leukopenia
- Lymphopenia
- Neutropenic disorder
- Pregnancy
- Prolonged QT interval
- Severe hepatic disease
- Severe infection
- Thrombocytopenic disorder
Severe
Moderate
- End-stage renal disease
ROMIDEPSIN (romidepsin)
- Cutaneous t-cell lymphoma
- Peripheral t-cell lymphoma
- Abnormal ECG
- Anemia
- Hypomagnesemia
- Infection
- Lymphopenia
- Neutropenic disorder
- Thrombocytopenic disorder
- Anorexia
- Cough
- Diarrhea
- Dysgeusia
- Fatigue
- Fever
- General weakness
- Hyperuricemia
- Leukopenia
- Nausea
- Vomiting
More Frequent
Severe
Less Severe
- Abnormal hepatic function tests
- Bacterial sepsis
- Cardiac arrhythmia
- Cellulitis
- Chest pain
- Deep venous thrombosis
- Dehydration
- Exfoliative dermatitis
- Hypokalemia
- Pneumonia
- Acute abdominal pain
- Chills
- Constipation
- Headache disorder
- Hyperglycemia
- Hypoalbuminemia
- Hypotension
- Peripheral edema
- Pruritus of skin
- Stomatitis
- Tachycardia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Dyspnea
- Hypersensitivity drug reaction
- Hypocalcemia
- Increased alanine transaminase
- Increased aspartate transaminase
- Interstitial pneumonitis
- Prolonged QT interval
- Pulmonary thromboembolism
- Reactivation of epstein-barr virus infection
- Reactivation of hepatitis B
- Ventricular arrhythmias
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Romidepsin
Safety and efficacy not established.
- 1 Day – 18 Years
- Safety and efficacy not established.
Romidepsin
- Severity Level:
D
- Additional Notes: Insufficient human data avail; animal data suggest embryotoxicity
Contraindicated
Romidepsin
Insufficient human data available; may cause fetal harm
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Insufficient human data available; may cause fetal harm |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Cutaneous t-cell lymphoma | |
| C84.0 | Mycosis fungoides |
| C84.00 | Mycosis fungoides, unspecified site |
| C84.01 | Mycosis fungoides, lymph nodes of head, face, and neck |
| C84.02 | Mycosis fungoides, intrathoracic lymph nodes |
| C84.03 | Mycosis fungoides, intra-abdominal lymph nodes |
| C84.04 | Mycosis fungoides, lymph nodes of axilla and upper limb |
| C84.05 | Mycosis fungoides, lymph nodes of inguinal region and lower limb |
| C84.06 | Mycosis fungoides, intrapelvic lymph nodes |
| C84.07 | Mycosis fungoides, spleen |
| C84.08 | Mycosis fungoides, lymph nodes of multiple sites |
| C84.09 | Mycosis fungoides, extranodal and solid organ sites |
| C84.1 | Sezary disease |
| C84.10 | Sezary disease, unspecified site |
| C84.11 | Sezary disease, lymph nodes of head, face, and neck |
| C84.12 | Sezary disease, intrathoracic lymph nodes |
| C84.13 | Sezary disease, intra-abdominal lymph nodes |
| C84.14 | Sezary disease, lymph nodes of axilla and upper limb |
| C84.15 | Sezary disease, lymph nodes of inguinal region and lower limb |
| C84.16 | Sezary disease, intrapelvic lymph nodes |
| C84.17 | Sezary disease, spleen |
| C84.18 | Sezary disease, lymph nodes of multiple sites |
| C84.19 | Sezary disease, extranodal and solid organ sites |
| C84.A | Cutaneous t-cell lymphoma, unspecified |
| C84.A0 | Cutaneous t-cell lymphoma, unspecified, unspecified site |
| C84.A1 | Cutaneous t-cell lymphoma, unspecified lymph nodes of head, face, and neck |
| C84.A2 | Cutaneous t-cell lymphoma, unspecified, intrathoracic lymph nodes |
| C84.A3 | Cutaneous t-cell lymphoma, unspecified, intra-abdominal lymph nodes |
| C84.A4 | Cutaneous t-cell lymphoma, unspecified, lymph nodes of axilla and upper limb |
| C84.A5 | Cutaneous t-cell lymphoma, unspecified, lymph nodes of inguinal region and lower limb |
| C84.A6 | Cutaneous t-cell lymphoma, unspecified, intrapelvic lymph nodes |
| C84.A7 | Cutaneous t-cell lymphoma, unspecified, spleen |
| C84.A8 | Cutaneous t-cell lymphoma, unspecified, lymph nodes of multiple sites |
| C84.A9 | Cutaneous t-cell lymphoma, unspecified, extranodal and solid organ sites |
| C86.6 | Primary cutaneous Cd30-positive t-cell proliferations |
| Peripheral t-cell lymphoma | |
| C84.4 | Peripheral t-cell lymphoma, not classified |
| C84.40 | Peripheral t-cell lymphoma, not classified, unspecified site |
| C84.41 | Peripheral t-cell lymphoma, not classified, lymph nodes of head, face, and neck |
| C84.42 | Peripheral t-cell lymphoma, not classified, intrathoracic lymph nodes |
| C84.43 | Peripheral t-cell lymphoma, not classified, intra-abdominal lymph nodes |
| C84.44 | Peripheral t-cell lymphoma, not classified, lymph nodes of axilla and upper limb |
| C84.45 | Peripheral t-cell lymphoma, not classified, lymph nodes of inguinal region and lower limb |
| C84.46 | Peripheral t-cell lymphoma, not classified, intrapelvic lymph nodes |
| C84.47 | Peripheral t-cell lymphoma, not classified, spleen |
| C84.48 | Peripheral t-cell lymphoma, not classified, lymph nodes of multiple sites |
| C84.49 | Peripheral t-cell lymphoma, not classified, extranodal and solid organ sites |
| 0-9 | A-Z |
|---|---|
| C84.0 | Mycosis fungoides |
| C84.00 | Mycosis fungoides, unspecified site |
| C84.01 | Mycosis fungoides, lymph nodes of head, face, and neck |
| C84.02 | Mycosis fungoides, intrathoracic lymph nodes |
| C84.03 | Mycosis fungoides, intra-abdominal lymph nodes |
| C84.04 | Mycosis fungoides, lymph nodes of axilla and upper limb |
| C84.05 | Mycosis fungoides, lymph nodes of inguinal region and lower limb |
| C84.06 | Mycosis fungoides, intrapelvic lymph nodes |
| C84.07 | Mycosis fungoides, spleen |
| C84.08 | Mycosis fungoides, lymph nodes of multiple sites |
| C84.09 | Mycosis fungoides, extranodal and solid organ sites |
| C84.1 | Sezary disease |
| C84.10 | Sezary disease, unspecified site |
| C84.11 | Sezary disease, lymph nodes of head, face, and neck |
| C84.12 | Sezary disease, intrathoracic lymph nodes |
| C84.13 | Sezary disease, intra-abdominal lymph nodes |
| C84.14 | Sezary disease, lymph nodes of axilla and upper limb |
| C84.15 | Sezary disease, lymph nodes of inguinal region and lower limb |
| C84.16 | Sezary disease, intrapelvic lymph nodes |
| C84.17 | Sezary disease, spleen |
| C84.18 | Sezary disease, lymph nodes of multiple sites |
| C84.19 | Sezary disease, extranodal and solid organ sites |
| C84.4 | Peripheral t-cell lymphoma, not classified |
| C84.40 | Peripheral t-cell lymphoma, not classified, unspecified site |
| C84.41 | Peripheral t-cell lymphoma, not classified, lymph nodes of head, face, and neck |
| C84.42 | Peripheral t-cell lymphoma, not classified, intrathoracic lymph nodes |
| C84.43 | Peripheral t-cell lymphoma, not classified, intra-abdominal lymph nodes |
| C84.44 | Peripheral t-cell lymphoma, not classified, lymph nodes of axilla and upper limb |
| C84.45 | Peripheral t-cell lymphoma, not classified, lymph nodes of inguinal region and lower limb |
| C84.46 | Peripheral t-cell lymphoma, not classified, intrapelvic lymph nodes |
| C84.47 | Peripheral t-cell lymphoma, not classified, spleen |
| C84.48 | Peripheral t-cell lymphoma, not classified, lymph nodes of multiple sites |
| C84.49 | Peripheral t-cell lymphoma, not classified, extranodal and solid organ sites |
| C84.A | Cutaneous t-cell lymphoma, unspecified |
| C84.A0 | Cutaneous t-cell lymphoma, unspecified, unspecified site |
| C84.A1 | Cutaneous t-cell lymphoma, unspecified lymph nodes of head, face, and neck |
| C84.A2 | Cutaneous t-cell lymphoma, unspecified, intrathoracic lymph nodes |
| C84.A3 | Cutaneous t-cell lymphoma, unspecified, intra-abdominal lymph nodes |
| C84.A4 | Cutaneous t-cell lymphoma, unspecified, lymph nodes of axilla and upper limb |
| C84.A5 | Cutaneous t-cell lymphoma, unspecified, lymph nodes of inguinal region and lower limb |
| C84.A6 | Cutaneous t-cell lymphoma, unspecified, intrapelvic lymph nodes |
| C84.A7 | Cutaneous t-cell lymphoma, unspecified, spleen |
| C84.A8 | Cutaneous t-cell lymphoma, unspecified, lymph nodes of multiple sites |
| C84.A9 | Cutaneous t-cell lymphoma, unspecified, extranodal and solid organ sites |
| C86.6 | Primary cutaneous Cd30-positive t-cell proliferations |
Formulary Reference Tool