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XALKORI (CRIZOTINIB)
- ALK positive non-small cell lung cancer
- ROs1 positive non-small cell lung cancer
200 mg capsule
- 1 capsule (200 mg) by oral route 2 times per day
250 mg capsule
- 1 capsule (250 mg) by oral route 2 times per day
ALK positive non-small cell lung cancer
- 1 capsule (200 mg) by oral route 2 times per day
- 1 capsule (250 mg) by oral route 2 times per day
- 1 capsule (250 mg) by oral route once daily
ROs1 positive non-small cell lung cancer
- 1 capsule (200 mg) by oral route 2 times per day
- 1 capsule (250 mg) by oral route 2 times per day
- 1 capsule (250 mg) by oral route once daily
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- Juxtapid
- lomitapide
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- Abstral
- Actiq
- Alfenta
- alfentanil
- amiodarone
- amiodarone in dextrose,iso-osm
- artemether-lumefantrine
- Astagraf Xl
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- Bosulif
- bosutinib
- Cafergot
- calcium-mag-B complex-D3-hrb61
- carbamazepine
- Carbatrol
- Cerebyx
- clozapine
- Clozaril
- Coartem
- colchicine
- colchicine-probenecid
- Colcrys
- Cold & Flu Fighter
- Cordarone
- cyclosporine
- cyclosporine modified
- D.h.e.45
- deferiprone
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- dextromethorphan-quinidine
- Diflucan
- dihydroergotamine
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- disopyramide
- Donnatal
- dronedarone
- droperidol
- Duragesic
- enzalutamide
- Epitol
- Equetro
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- Fatigue Relief Complex
- Fazaclo
- fentanyl
- fentanyl citrate
- fentanyl citrate (PF)
- Fentora
- Ferriprox
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fosphenytoin
- Gengraf
- Geodon
- guanfacine
- Hecoria
- ibrutinib
- Imbruvica
- Intuniv Er
- isoniazid-rifamp-pyrazinamide
- Lazanda
- Luminal
- Migergot
- Migranal
- Multaq
- Mycobutin
- Mysoline
- Neoral
- Nexterone
- Norpace
- Norpace Cr
- Nuedexta
- Olysio
- Orap
- Pacerone
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- pimozide
- primidone
- Prograf
- quinidine gluconate
- quinidine sulfate
- Rapamune
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Samsca
- Sandimmune
- simeprevir
- sirolimus
- St. John's wort
- Sublimaze (pf)
- Subsys
- tacrolimus
- Tegretol
- Tegretol Xr
- Tenex
- thioridazine
- tolvaptan
- Versacloz
- vit C-St. John wort-elder-hb30
- Women's Complex
- Xtandi
- ziprasidone HCl
- ziprasidone mesylate
Severe
Moderate
- Ablavar
- Advair Diskus
- Advair Hfa
- Afinitor
- Afinitor Disperz
- alfuzosin
- Aloxi
- amantadine HCl
- Anzemet
- Apokyn
- apomorphine
- arsenic trioxide
- avanafil
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- azithromycin
- bedaquiline
- Betapace
- Betapace Af
- bosentan
- budesonide-formoterol
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- Celexa
- chloroquine phosphate
- chlorpromazine
- cilostazol
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- citalopram
- Complera
- Corvert
- dasatinib
- Diskets
- dofetilide
- dolasetron
- Dolophine
- Dulera
- Edurant
- Effexor Xr
- emtricitab-rilpivirine-tenofov
- Eovist
- eplerenone
- eribulin
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- everolimus
- ezogabine
- Fareston
- felbamate
- Felbatol
- flecainide
- fluticasone-salmeterol
- Foradil Aerolizer
- formoterol fumarate
- foscarnet
- Foscavir
- gadofosveset trisodium
- gadoxetate
- granisetron
- granisetron (PF)
- Granisol
- Halaven
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- ibutilide fumarate
- indapamide
- Inspra
- Invega
- Invega Sustenna
- isradipine
- Istodax
- ivacaftor
- Kaletra
- Kalydeco
- lapatinib
- Levaquin
- Levaquin In 5 % Dextrose
- Levitra
- levofloxacin
- levofloxacin in D5W
- lithium carbonate
- lithium citrate
- Lithobid
- lopinavir-ritonavir
- methadone
- Methadone Intensol
- Methadose
- moexipril
- moexipril-hydrochlorothiazide
- mometasone-formoterol
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Nebupent
- Nexavar
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- nilotinib
- norfloxacin
- Noroxin
- octreotide acetate
- ofloxacin
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- paliperidone
- paliperidone palmitate
- palonosetron
- pasireotide
- pazopanib
- Pentam
- pentamidine
- Perforomist
- Pletal
- Potiga
- procainamide
- propafenone
- Qualaquin
- quetiapine
- quinine sulfate
- rilpivirine
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- romidepsin
- Rythmol
- salmeterol
- Sancuso
- Sandostatin
- Sandostatin Lar Depot
- Serevent Diskus
- Seroquel
- Seroquel Xr
- Signifor
- Sirturo
- Soltamox
- sorafenib
- Sorine
- sotalol
- Sotalol Af
- Sprycel
- Stendra
- Symbicort
- tamoxifen
- Tasigna
- telavancin
- tetrabenazine
- Tikosyn
- tizanidine
- toremifene
- Tracleer
- Trisenox
- Tykerb
- Uniretic
- Univasc
- Uroxatral
- vardenafil
- vemurafenib
- venlafaxine
- Vibativ
- Votrient
- Xenazine
- Zanaflex
- Zelboraf
- Zithromax
- Zithromax Tri-pak
- Zithromax Z-pak
- Zmax
- Zofran
- Zofran Odt
- Zortress
- Zuplenz
- Congenital long QT syndrome
- Lactating mother
- Torsades de pointes
Contraindicated
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Hypokalemia
- Hypomagnesemia
- Interstitial pneumonitis
- Pregnancy
- Prolonged QT interval
Severe
Moderate
- Abnormal hepatic function tests
- Bradycardia
- Chronic heart failure
- Hyperbilirubinemia
- Lymphopenia
- Neutropenic disorder
- Peripheral neuropathy
XALKORI (CRIZOTINIB)
- ALK positive non-small cell lung cancer
- ROs1 positive non-small cell lung cancer
- Hypophosphatemia
- Increased alanine transaminase
- Increased aspartate transaminase
- Lymphopenia
- Neutropenic disorder
- Visual changes
- Acute abdominal pain
- Anorexia
- Blurred vision
- Constipation
- Diarrhea
- Dizziness
- Dysgeusia
- Edema
- Fatigue
- Headache disorder
- Kidney disease with reduction in GFR
- Nausea
- Peripheral neuropathy
- Upper respiratory infection
- Vomiting
More Frequent
Severe
Less Severe
- Bradycardia
- Dyspnea
- Hepatic failure
- Interstitial pneumonitis
- Pneumonia
- Prolonged QT interval
- Pulmonary thromboembolism
- Renal cyst
- Vitreous floater
- Androgen deficiency
- Dyspepsia
- Dysphagia
- Esophagitis
- Fever
- Gait abnormality
- Hypesthesia
- Limb pain
- Male hypogonadism
- Muscle spasm
- Muscle weakness
- Neuralgia
- Paresthesia
- Peripheral sensory neuropathy
- Skin rash
- Syncope
- Weight gain
- Weight loss
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute respiratory distress syndrome
- Cardiac arrhythmia
- Diabetic ketoacidosis
- Hepatitis
- Hyperbilirubinemia
- Increased creatine kinase level
- Optic atrophy
- Optic nerve damage
- Photopsia
- Septic shock
- Vision loss
Less Severe
- None
Contraindicated
None
Severe Precaution
Crizotinib
Potential for decreased bone formation. No safety and efficacy established.
- 1 Day – 18 Years
- Potential for decreased bone formation. No safety and efficacy established.
Management or Monitoring Precaution
None
Crizotinib
- Severity Level:
D
- Additional Notes: Insufficient human data avail; consider maternal benefit vs fetal/neonatal risk
Contraindicated
Crizotinib
Potentially harmful to infant based on mechanism of action
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Potentially harmful to infant based on mechanism of action |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Crizotinib
Cardiovascular-May cause bradycardia. Elderly may be more susceptible to QT prolongation. Caution with concomitant bradycardia, electrolyte disturbance or underlying cardiac arrhythmia. Hepatic-Rare risk of fatal hepatotoxicity. Monitor hepatic function. Vision-Use caution in the elderly with vision impairment due to risk for bilateral visual field impairment.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | Y | Y | N | Y | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| ALK positive non-small cell lung cancer | |
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
| ROs1 positive non-small cell lung cancer | |
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
| 0-9 | A-Z |
|---|---|
| C34 | Malignant neoplasm of bronchus and lung |
| C34 | Malignant neoplasm of bronchus and lung |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.0 | Malignant neoplasm of main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.00 | Malignant neoplasm of unspecified main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.01 | Malignant neoplasm of right main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.02 | Malignant neoplasm of left main bronchus |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
| C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
| C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
Formulary Reference Tool