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FRAGMIN (DALTEPARIN SODIUM,PORCINE)
- Deep vein thrombosis prevention
- Prevention of cardiac ischemia in unstable angina
- Prevention of ischemic complications of non-Q wave MI
- Abdominal surgery deep vein thrombosis prevention
- Hip surgery deep vein thrombosis prevention
- Non q-wave myocardial infarction
- Prevention of recurrent venous thrombosis in malignancy
- Unstable angina pectoris
10,000 anti-Xa unit/mL subcutaneous syringe
- Inject 0.25 milliliter (2,500 unit) by subcutaneous route once daily
12,500 anti-Xa unit/0.5 mL subcutaneous syringe
- Inject 5,000 unit by subcutaneous route once daily
15,000 anti-Xa unit/0.6 mL subcutaneous syringe
- Inject 5,000 unit by subcutaneous route once daily
18,000 anti-Xa unit/0.72 mL subcutaneous syringe
- Inject 5,000 unit by subcutaneous route once daily
2,500 anti-Xa unit/0.2 mL subcutaneous syringe
- Inject 0.2 milliliter (2,500 unit) by subcutaneous route once daily
5,000 anti-Xa unit/0.2 mL subcutaneous syringe
- Inject 0.1 milliliter (2,500 unit) by subcutaneous route once daily
7,500 anti-Xa unit/0.3 mL subcutaneous syringe
- Inject 0.1 milliliter (2,500 unit) by subcutaneous route once daily
25,000 anti-Xa unit/mL subcutaneous solution
- Inject 1 milliliter (2,500 unit) by subcutaneous route once daily
Abdominal surgery deep vein thrombosis prevention
- Inject 2,500 unit by subcutaneous route once daily for 5 days
- Inject 2,500 unit by subcutaneous route once daily for 10 days
- Inject 2,500 unit by subcutaneous route once daily
- Inject 1 milliliter (2,500 unit) by subcutaneous route once daily
- Inject 1 milliliter (2,500 unit) by subcutaneous route once daily for5 days
- Inject 1 milliliter (2,500 unit) by subcutaneous route once daily for10 days
- Inject 0.1 milliliter (2,500 unit) by subcutaneous route once daily
- Inject 0.1 milliliter (2,500 unit) by subcutaneous route once daily for 5 days
- Inject 0.1 milliliter (2,500 unit) by subcutaneous route once daily for 10 days
- Inject 0.2 milliliter (2,500 unit) by subcutaneous route once daily
- Inject 0.2 milliliter (2,500 unit) by subcutaneous route once daily for 5 days
- Inject 0.2 milliliter (2,500 unit) by subcutaneous route once daily for 10 days
- Inject 0.25 milliliter (2,500 unit) by subcutaneous route once daily
- Inject 0.25 milliliter (2,500 unit) by subcutaneous route once daily for 5 days
- Inject 0.25 milliliter (2,500 unit) by subcutaneous route once daily for 10 days
Deep vein thrombosis prevention
- Inject 5,000 unit by subcutaneous route once the evening before surgery
- Inject 5,000 unit by subcutaneous route once daily
- Inject 5,000 unit by subcutaneous route once daily for 12 days
- Inject 5,000 unit by subcutaneous route once daily for 14 days
Hip surgery deep vein thrombosis prevention
- Inject 5,000 unit by subcutaneous route once daily for 5 days
- Inject 5,000 unit by subcutaneous route once daily for 10 days
- Inject 5,000 unit by subcutaneous route once daily
- Inject 2 milliliters (5,000 unit) by subcutaneous route once daily
- Inject 2 milliliters (5,000 unit) by subcutaneous route once daily for 5 days
- Inject 2 milliliters (5,000 unit) by subcutaneous route once daily for 10 days
- Inject 0.5 milliliter (5,000 unit) by subcutaneous route once daily
- Inject 0.5 milliliter (5,000 unit) by subcutaneous route once daily for 5 days
- Inject 0.5 milliliter (5,000 unit) by subcutaneous route once daily for 10 days
- Inject 0.4 milliliter (5,000 unit) by subcutaneous route once daily
- Inject 0.4 milliliter (5,000 unit) by subcutaneous route once daily for 5 days
- Inject 0.4 milliliter (5,000 unit) by subcutaneous route once daily for 10 days
- Inject 0.2 milliliter (5,000 unit) by subcutaneous route once daily
- Inject 0.2 milliliter (5,000 unit) by subcutaneous route once daily for 5 days
- Inject 0.2 milliliter (5,000 unit) by subcutaneous route once daily for 10 days
Non q-wave myocardial infarction
- Inject 120 unit/kg by subcutaneous route every 12 hours up to a maximum dose of 10,000 units
- Inject 120 unit/kg by subcutaneous route every 12 hours up to a maximum dose of 10,000 units for 5 days
- Inject 120 unit/kg by subcutaneous route every 12 hours up to a maximum dose of 10,000 units for 8 days
Prevention of cardiac ischemia in unstable angina
- Inject 120 unit/kg by subcutaneous route every 12 hours up to a maximum dose of 10,000 units
- Inject 120 unit/kg by subcutaneous route every 12 hours up to a maximum dose of 10,000 units for 5 days
- Inject 120 unit/kg by subcutaneous route every 12 hours up to a maximum dose of 10,000 units for 8 days
Prevention of ischemic complications of non-Q wave MI
- Inject 120 unit/kg by subcutaneous route every 12 hours up to a maximum dose of 10,000 units
- Inject 120 unit/kg by subcutaneous route every 12 hours up to a maximum dose of 10,000 units for 5 days
- Inject 120 unit/kg by subcutaneous route every 12 hours up to a maximum dose of 10,000 units for 8 days
Prevention of recurrent venous thrombosis in malignancy
- Inject 5,000 unit by subcutaneous route once daily for 5 days
- Inject 5,000 unit by subcutaneous route once daily for 10 days
- Inject 5,000 unit by subcutaneous route once daily
- Inject 150 unit/kg (not to exceed 18,000 units) by subcutaneous routeonce daily
Pulmonary thromboembolism prevention
- Inject 2,500 unit by subcutaneous route once daily for 5 days
- Inject 2,500 unit by subcutaneous route once daily for 10 days
- Inject 2,500 unit by subcutaneous route once daily
- Inject 2,500 unit by subcutaneous route once, 1-2 hours before surgery
- Inject 5,000 unit by subcutaneous route once the evening before surgery
- Inject 5,000 unit by subcutaneous route once daily for 5 days
- Inject 5,000 unit by subcutaneous route once daily for 10 days
- Inject 5,000 unit by subcutaneous route once daily
Unstable angina pectoris
- Inject 120 unit/kg by subcutaneous route every 12 hours up to a maximum dose of 10,000 units
- Inject 120 unit/kg by subcutaneous route every 12 hours up to a maximum dose of 10,000 units for 5 days
- Inject 120 unit/kg by subcutaneous route every 12 hours up to a maximum dose of 10,000 units for 8 days
- Mifeprex
- mifepristone
Contraindicated
- abciximab
- Activase
- alteplase
- ketorolac
- Reopro
- Sprix
Severe
Moderate
- acetaminophen-mag sal-pamabrom
- Added Strength Headache Relief
- Added Strength Pain Reliever
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- Aggrastat In Sodium Chloride
- Aggrenox
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- Alka-seltzer
- Alka-seltzer Extra Strength
- Alka-seltzer Original
- Alka-seltzer Plus C/c(pe,dm)
- Alka-seltzer Plus Cold (pe)
- Alka-seltzer Plus Day-night
- Alka-seltzer Plus Night
- Alka-seltzer Pm
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- Anacin
- Anacin Maximum Strength
- Analgesic
- Anaprox
- Anaprox Ds
- Ansaid
- Antacid & Pain Relief
- Apriso
- Arthri-flex
- Arthrotec 50
- ASA-acetaminophen-caff-buffers
- ASA-acetaminophen-salicyl-caff
- Asacol Hd
- Ascomp With Codeine
- aspirin
- aspirin, buffered
- aspirin-acetaminophen-caffeine
- aspirin-caffeine
- aspirin-diphenhydramine
- aspirin-diphenhydramine citrat
- aspirin-sod bicarb-citric acid
- Back & Body Pain Reliever
- Back Pain-off
- Backache Relief
- Backache Relief Extra Strength
- balsalazide
- Bayer Advanced
- Bayer Aspirin (with Caffeine)
- Bayer Back & Body
- Bayer Plus Extra Strength
- Bayer Pm
- Bc
- Bc Arthritis
- Bismatrol
- Bismuth
- Bismuth Maximum Strength
- bismuth subsalicylate
- Brilinta
- Brintellix
- Brisdelle
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-aspirin-caffeine
- Caldolor
- Cambia
- Canasa
- carisoprodol-ASA-codeine
- carisoprodol-aspirin
- Cataflam
- Celexa
- Child Ibuprofen
- Children's Advil
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-DM-aspirin
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- chlorphenir-phenylephrn-aspirn
- choline & magnesium salicylate
- cilostazol
- citalopram
- clopidogrel
- codeine-butalbital-ASA-caff
- Colazal
- Cold & Sinus Pain Relief
- Cold Relief
- Cold Relief Plus
- Cold-sinus Relief
- Coumadin
- Cymbalta
- Cystex (methenamine & Sod Sal)
- Daypro
- Delzicol
- desvenlafaxine
- desvenlafaxine fumarate
- desvenlafaxine succinate
- Diarrhea Relief (bismuth Subs)
- diclofenac epolamine
- diclofenac potassium
- diclofenac sodium
- diclofenac submicronized
- diclofenac-misoprostol
- dihydrocodeine-aspirin-caff
- Diotame
- Diotame Instydose
- Dipentum
- dipyridamole
- dipyridamole-aspirin
- doxylamine-phenylep-DM-aspirin
- Duexis
- duloxetine
- Ec-naprosyn
- Efferves Pain Relief Antacid
- Effervescent Antacid
- Effervescent Pain Relief
- Effervescent Pain Reliever
- Effexor Xr
- Elmiron
- Endodan
- eptifibatide
- escitalopram oxalate
- etodolac
- Excedrin Extra Strength
- Excedrin Migraine
- Extra Strength Bayer
- Feldene
- fenoprofen
- Fetzima
- Fiorinal
- Fiorinal-codeine #3
- Flanax
- Flector
- fluoxetine
- flurbiprofen
- fluvoxamine
- Giazo
- gluc-msm-coll2-hyal-antiarthr3
- glucos-msm-C-Mn-ginger-willow
- glucos-msm-C-Mn-herb#21
- glucos-msm-collagen-C-Mn-hrb21
- Glucosamine-msm Complex
- Goody's Extra Strength
- Goody's Migraine Relief
- Headache Formula
- Headache Formula Added Str
- Headache Relief
- hydrocodone-ibuprofen
- Hyophen
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-oxycodone
- ibuprofen-phenylephrine HCl
- Indocin
- indomethacin
- indomethacin sodium
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- Integrilin
- Jantoven
- K-pec Antidiarrheal (bism Sub)
- Kao-tin (bismuth Subsalicylat)
- Kaopectate (bismuth Subsalicy)
- Kaopectate Child(bis Ssalicyl)
- Kaopectate Ex Str (bismuth Ss)
- ketoprofen
- Khedezla
- Kola-pectin Ds
- Levacet
- levomilnacipran
- Lexapro
- Lialda
- Luvox Cr
- magnesium salicylate
- Medi-bismuth
- Medi-profen
- Medi-seltzer
- Mediproxen
- mefenamic acid
- meloxicam
- mesalamine
- mesalamine-cleansing wipes
- methen-hyos-me blue-ba-salicyl
- methen-hyosc-m.blue-sal-naphos
- methenamine-sodium salicylate
- Mg salicylat-acetaminophen-caf
- Midol (naproxen)
- Migraine Formula
- Migraine Pain Reliever
- Migraine Relief
- milnacipran
- Mobic
- Motrin Ib
- Motrin Pm
- Msm Glucosamine Complex
- mth-me blue-sod phos-phsal-hyo
- nabumetone
- Nalfon
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- Neoprofen (ibuprofen Lysn)(pf)
- olanzapine-fluoxetine
- olsalazine
- Orphenadrine Compound Forte
- Orphenadrine Compound-ds
- orphenadrine-ASA-caffeine
- oxaprozin
- oxycodone-aspirin
- Pain Relief
- Pain Relief Extra Strength
- Pain Reliever
- Pain Reliever Extra Strength
- Pain Reliever Plus
- Pain-off
- Pamprin (with Mag Salicylate)
- Pamprin Max
- paroxetine HCl
- paroxetine mesylate
- Paxil
- Paxil Cr
- PE-DM-ASA/doxyla-PE-DM-ASA
- Pennsaid
- Pentasa
- pentosan polysulfate sodium
- Peptic Relief
- Pepto-bismol
- Pepto-bismol Max St
- Pepto-bismol To-go
- Percodan
- Persantine
- Pexeva
- Phosphasal
- Pink Bismuth
- Pink Bismuth Maximum Strength
- piroxicam
- Plavix
- Pletal
- Ponstel
- Pristiq
- Prosed/ds (atropine Free)
- Provil
- Prozac
- Prozac Weekly
- pseudoephedrine-ibuprofen
- Reprexain
- Retavase
- reteplase
- rivaroxaban
- Rowasa
- salsalate
- Sarafem
- Savella
- sertraline
- Sfrowasa
- Sinus & Cold-d
- Solaraze
- Soothe (bismuth Subsalicylate)
- Soothe Regular Strength
- Stomach Relief
- Stomach Relief Max Strength
- Stomach Relief Original
- sulindac
- Super Pain Relief
- Symbyax
- Synalgos-dc
- ticagrelor
- ticlopidine
- tirofiban-0.9% sodium chloride
- tolmetin
- Ur N-c
- Urelle
- Uretron D-s
- Uribel
- Urimar-t
- Urin Ds
- Ustell
- Uta
- Vanquish
- venlafaxine
- Vicoprofen
- Viibryd
- vilazodone
- Vimovo
- Voltaren-xr
- vortioxetine
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- warfarin
- Xarelto
- Zipsor
- Zoloft
- Zorvolex
- Gastrointestinal hemorrhage
- Hemorrhage
- Hemorrhagic stroke
- Heparin-induced thrombocytopenia
- Invasive procedure on brain
- Surgical procedure on eye proper
Contraindicated
- Bacterial endocarditis
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Deep peripheral nerve block
- Deep plexus block
- Diabetic retinopathy
- Gastrointestinal ulcer
- Hypertensive retinopathy
- Increased risk of bleeding
- Increased risk of bleeding due to coagulation disorder
- Invasive procedure on spine
- Neuraxial anesthesia
- Placement of indwelling epidural catheter
- Platelet aggregation inhibition
- Qualitative platelet disorder
- Severe hepatic disease
- Severe uncontrolled hypertension
- Thrombocytopenic disorder
Severe
Moderate
- Kidney disease with likely reduction in GFR
FRAGMIN (DALTEPARIN SODIUM,PORCINE)
- Deep vein thrombosis prevention
- Prevention of cardiac ischemia in unstable angina
- Prevention of ischemic complications of non-Q wave MI
- Abdominal surgery deep vein thrombosis prevention
- Hip surgery deep vein thrombosis prevention
- Non q-wave myocardial infarction
- Prevention of recurrent venous thrombosis in malignancy
- Unstable angina pectoris
- Hematoma
- Injection site sequelae
- Bruising
More Frequent
Severe
Less Severe
- Hemorrhage
- Increased alanine transaminase
- Increased aspartate transaminase
- None
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Anaphylaxis
- Bullous dermatitis
- Dermal necrosis
- Drug fever
- Intracranial bleeding
- Osteoporosis
- Retroperitoneal hemorrhage
- Spinal epidural hematoma
- Thrombocytopenic disorder
Less Severe
- Alopecia
- Pruritus of skin
- Skin rash
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Dalteparin
Safety and efficacy have not been established in < 1 month.
- 1 Day – 27 Days
- Safety and efficacy have not been established in < 1 month.
Dalteparin
- Severity Level:
2
- Additional Notes: Risk of spinal hematoma &poss paralysis,if used with spinal/epidural anesthesia
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Dalteparin
Excreted in small amounts; oral absorption is poor
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Excreted in small amounts; oral absorption is poor |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Dalteparin
Renal-Dosage adjustment should be based on weight and renal function to minimize risk of bleeding. General-Caution with concomitant antiplatelet agents.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- People using this medication may bleed near the spinal cord after certain spinal procedures. Bleeding in this area can cause paralysis that lasts a long time or could become permanent. Talk with your doctor about the benefits and risks before any spinal procedure.<br /><br />Your doctor may direct you to stop this medication for a certain amount of time before and after the procedure. Carefully follow your doctor's directions. The risk of bleeding may be higher if you have a deformed spine, or have had spinal procedures/surgery before (such as epidural catheter placement, difficult epidural/spinal puncture), or are taking other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, "blood thinners" such as warfarin/rivaroxaban, nonsteroidal anti-inflammatory drugs-NSAIDs such as ibuprofen). Tell your doctor right away if you notice symptoms such as back pain, leg numbness/tingling/weakness, loss of control of the bowels or bladder (incontinence).
| Deep vein thrombosis prevention | |
| Z86.71 | Personal history of venous thrombosis and embolism |
| Z86.711 | Personal history of pulmonary embolism |
| Z86.718 | Personal history of other venous thrombosis and embolism |
| Z86.72 | Personal history of thrombophlebitis |
| Non q-wave myocardial infarction | |
| I21.4 | Non-ST elevation (NSTEMi) myocardial infarction |
| I22.2 | Subsequent non-ST elevation (NSTEMi) myocardial infarction |
| Prevention of cardiac ischemia in unstable angina | |
| I20.0 | Unstable angina |
| I25.110 | Atherosclerotic heart disease of native coronary artery with unstable angina pectoris |
| I25.700 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with unstable angina pectoris |
| I25.710 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with unstable angina pectoris |
| I25.720 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with unstable angina pectoris |
| I25.730 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unstable angina pectoris |
| I25.750 | Atherosclerosis of native coronary artery of transplanted heart with unstable angina |
| I25.760 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with unstable angina |
| I25.790 | Atherosclerosis of other coronary artery bypass graft(s) with unstable angina pectoris |
| Prevention of ischemic complications of non-Q wave MI | |
| I21.4 | Non-ST elevation (NSTEMi) myocardial infarction |
| I22.2 | Subsequent non-ST elevation (NSTEMi) myocardial infarction |
| Unstable angina pectoris | |
| I20.0 | Unstable angina |
| I25.110 | Atherosclerotic heart disease of native coronary artery with unstable angina pectoris |
| I25.700 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with unstable angina pectoris |
| I25.710 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with unstable angina pectoris |
| I25.720 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with unstable angina pectoris |
| I25.730 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unstable angina pectoris |
| I25.750 | Atherosclerosis of native coronary artery of transplanted heart with unstable angina |
| I25.760 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with unstable angina |
| I25.790 | Atherosclerosis of other coronary artery bypass graft(s) with unstable angina pectoris |
| 0-9 | A-Z |
|---|---|
| I20.0 | Unstable angina |
| I20.0 | Unstable angina |
| I21.4 | Non-ST elevation (NSTEMi) myocardial infarction |
| I21.4 | Non-ST elevation (NSTEMi) myocardial infarction |
| I22.2 | Subsequent non-ST elevation (NSTEMi) myocardial infarction |
| I22.2 | Subsequent non-ST elevation (NSTEMi) myocardial infarction |
| I25.110 | Atherosclerotic heart disease of native coronary artery with unstable angina pectoris |
| I25.110 | Atherosclerotic heart disease of native coronary artery with unstable angina pectoris |
| I25.700 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with unstable angina pectoris |
| I25.700 | Atherosclerosis of coronary artery bypass graft(s), unspecified, with unstable angina pectoris |
| I25.710 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with unstable angina pectoris |
| I25.710 | Atherosclerosis of autologous vein coronary artery bypass graft(s) with unstable angina pectoris |
| I25.720 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with unstable angina pectoris |
| I25.720 | Atherosclerosis of autologous artery coronary artery bypass graft(s) with unstable angina pectoris |
| I25.730 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unstable angina pectoris |
| I25.730 | Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unstable angina pectoris |
| I25.750 | Atherosclerosis of native coronary artery of transplanted heart with unstable angina |
| I25.750 | Atherosclerosis of native coronary artery of transplanted heart with unstable angina |
| I25.760 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with unstable angina |
| I25.760 | Atherosclerosis of bypass graft of coronary artery of transplanted heart with unstable angina |
| I25.790 | Atherosclerosis of other coronary artery bypass graft(s) with unstable angina pectoris |
| I25.790 | Atherosclerosis of other coronary artery bypass graft(s) with unstable angina pectoris |
| Z86.71 | Personal history of venous thrombosis and embolism |
| Z86.711 | Personal history of pulmonary embolism |
| Z86.718 | Personal history of other venous thrombosis and embolism |
| Z86.72 | Personal history of thrombophlebitis |
Formulary Reference Tool