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ABILIFY ASIMTUFII (aripiprazole)
- bipolar disorder in remission
- schizophrenia
720 mg/2.4 mL suspension, extend.rel. IM syringe
- Inject 720 mg by intramuscular route every 2 months
960 mg/3.2 mL suspension, extend.rel. IM syringe
- Inject 960 mg by intramuscular route every 2 months
Default screening record
- Inject 720 mg by intramuscular route every 2 months
- Inject 960 mg by intramuscular route every 2 months
- Inject 2.4 milliliters (720 mg) by intramuscular route every 2 months
- Inject 3.2 milliliters (960 mg) by intramuscular route every 2 months
- metoclopramide HCl
- Metozolv Odt
- Reglan
Contraindicated
- cabergoline
Severe
Moderate
- Apokyn
- apomorphine
- carbidopa-levodopa
- carbidopa-levodopa-entacapone
- Comtan
- entacapone
- Mirapex
- Mirapex Er
- pramipexole
- Requip
- Requip Xl
- ropinirole
- Sinemet
- Sinemet Cr
- Stalevo 100
- Stalevo 125
- Stalevo 150
- Stalevo 200
- Stalevo 50
- Stalevo 75
- None
Contraindicated
- Chronic heart failure
- CYp2d6 poor metabolizer
- Metabolic syndrome x
- Neuroleptic malignant syndrome
- Parkinsonism
- Senile dementia
- Suicidal ideation
- Tardive dyskinesia
Severe
Moderate
- Acute confusion
- Agranulocytosis
- Alzheimer's disease
- Cerebrovascular disorder
- Diabetes mellitus
- Esophageal dysmotility
- Hypotension
- Leukopenia
- Lower seizure threshold
- Myocardial ischemia
- Neutropenic disorder
- Obesity
- Orthostatic hypotension
- Predisposition to aspiration
- Seizure disorder
- Weight gain
ABILIFY ASIMTUFII (aripiprazole)
- bipolar disorder in remission
- schizophrenia
- Akathisia
- Agitation
- Constipation
- Dizziness
- Dyspepsia
- Headache disorder
- Hypertriglyceridemia
- Increased appetite
- Insomnia
- Nausea
- Symptoms of anxiety
- Vomiting
More Frequent
Severe
Less Severe
- Acquired dystonia
- Extrapyramidal disease
- Fever
- Hyperglycemia
- Orthostatic hypotension
- Skin rash
- Tardive dyskinesia
- Acute abdominal pain
- Anorexia
- Arthralgia
- Cough
- Diarrhea
- Dysmenorrhea
- Fatigue
- General weakness
- Hyperlipidemia
- Hyperprolactinemia
- Injection site pain
- Injection site sequelae
- Myalgia
- Nasal congestion
- Nervousness
- Pain
- Pharyngitis
- Toothache
- Tremor
- Weight gain
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Accidental fall
- Acute myocardial infarction
- Agranulocytosis
- Anaphylaxis
- Angioedema
- Aspiration pneumonia
- Atrial flutter
- Atrioventricular block
- Biliary calculus
- Bradycardia
- Chest pain
- Cholecystitis
- Diabetes mellitus
- Diabetic ketoacidosis
- DRESS syndrome
- Dysglycemia
- Dysphagia
- Esophageal dysmotility
- Heat stroke
- Hepatic failure
- Hepatitis
- Hepatomegaly
- Homicidal ideation
- Hypertension
- Hypoglycemic disorder
- Hypokalemia
- Hyponatremia
- Hypoprolactinemia
- Hypotension
- Increased creatine kinase level
- Jaundice
- Laryngismus
- Leukopenia
- Myocardial ischemia
- Neuroleptic malignant syndrome
- Neutropenic disorder
- Oculogyric crisis
- Pancreatitis
- Parkinsonism
- Peripheral edema
- Pneumonia
- Priapism
- Prolonged QT interval
- Rhabdomyolysis
- Seizure disorder
- Serotonin syndrome
- Sleep apnea
- Splenomegaly
- Steatosis of liver
- Stevens-johnson syndrome
- Suicidal ideation
- Tachycardia
- Thrombocytopenic disorder
- Upper respiratory infection
- Urinary retention
- Ventricular tachycardia
Less Severe
- Amenorrhea
- Anticholinergic toxicity
- Ataxia
- Blurred vision
- Compulsive gambling
- Diplopia
- Drowsy
- Dyspnea
- Erectile dysfunction
- Eyelid edema
- Facial edema
- Gastroesophageal reflux disease
- Gynecomastia
- Hiccups
- Hirsutism
- Hyperhidrosis
- Hypokinesia
- Impulse control disorder
- Increased libido
- Lethargy
- Mastalgia
- Memory impairment
- Menstrual disorder
- Muscle rigidity
- Muscle weakness
- Myoclonus
- Nocturia
- Orgasm disorder
- Palpitations
- Photophobia
- Pruritus of skin
- Sedation
- Sialorrhea
- Skin photosensitivity
- Sleep walking disorder
- Urinary incontinence
- Urticaria
- Weight loss
- Xerostomia
Contraindicated
None
Severe Precaution
Aripiprazole (Inj)
Risk of somnolence, increased extrapyramidal effects, weight gain. Possible increased suicidal ideation and attempt. Safety and efficacy not established.
- 1 Day – 18 Years
- Risk of somnolence, increased extrapyramidal effects, weight gain. Possible increased suicidal ideation and attempt. Safety and efficacy not established.
Management or Monitoring Precaution
None
Aripiprazole
- Severity Level:
2
- Additional Notes: Non-teratogenic complications (resp, gi,cns) with exposure during 3rd trimester
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Aripiprazole
Limited data sugg small amounts excreted; consider maternal tx vs infant risk
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data sugg small amounts excreted; consider maternal tx vs infant risk |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Aripiprazole
Neuro/Psych-Higher risk of tardive dyskinesia. CNS effects; sedation, cognitive impairment, and increased fall risk. Avoid use for behavioral problems of dementia or delirium unless failed nonpharmacological options. Increased risk of stroke, cognitive decline, and death when used with senile dementia. Endocrine-May exacerbate or cause SIADH or hyponatremia. Cardiovascular-May cause orthostatic hypotension. Gastrointestinal-May cause or worsen pre-existing constipation.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | Y | Y | N | Y |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- There may be a slightly increased risk of serious, possibly fatal side effects (such as stroke, heart failure, fast/irregular heartbeat, pneumonia) when this medication is used by older adults with dementia. This medication is not approved for the treatment of dementia-related behavior problems. Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor.
| Bipolar disorder in remission | |
| F31.7 | Bipolar disorder, currently in remission |
| F31.70 | Bipolar disorder, currently in remission, most recent episode unspecified |
| F31.71 | Bipolar disorder, in partial remission, most recent episode hypomanic |
| F31.72 | Bipolar disorder, in full remission, most recent episode hypomanic |
| F31.73 | Bipolar disorder, in partial remission, most recent episode manic |
| F31.74 | Bipolar disorder, in full remission, most recent episode manic |
| F31.75 | Bipolar disorder, in partial remission, most recent episode depressed |
| F31.76 | Bipolar disorder, in full remission, most recent episode depressed |
| F31.77 | Bipolar disorder, in partial remission, most recent episode mixed |
| F31.78 | Bipolar disorder, in full remission, most recent episode mixed |
| Schizophrenia | |
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
| 0-9 | A-Z |
|---|---|
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
| F31.7 | Bipolar disorder, currently in remission |
| F31.70 | Bipolar disorder, currently in remission, most recent episode unspecified |
| F31.71 | Bipolar disorder, in partial remission, most recent episode hypomanic |
| F31.72 | Bipolar disorder, in full remission, most recent episode hypomanic |
| F31.73 | Bipolar disorder, in partial remission, most recent episode manic |
| F31.74 | Bipolar disorder, in full remission, most recent episode manic |
| F31.75 | Bipolar disorder, in partial remission, most recent episode depressed |
| F31.76 | Bipolar disorder, in full remission, most recent episode depressed |
| F31.77 | Bipolar disorder, in partial remission, most recent episode mixed |
| F31.78 | Bipolar disorder, in full remission, most recent episode mixed |
Formulary Reference Tool