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NUDROXIPAK N-500 (nabumetone/capsaicin/methyl salicylate/menthol)
500 mg-0.025 %-25 %-6 % kit,topical liquid and tablet
- Dosage information is not available
- cidofovir
- ketorolac
- Sprix
- Vistide
Contraindicated
- Alimta
- apixaban
- Coumadin
- Curad Enema
- Disposable Enema
- Eliquis
- Enema
- Enema Disposable
- Fleet Enema
- Fleet Enema Extra
- Fleet Pediatric
- Folotyn
- Jantoven
- Methotrexate (anti-rheumatic)
- methotrexate sodium
- methotrexate sodium (PF)
- Oral Saline Laxative
- Osmoprep
- pemetrexed
- Phosphate Laxative
- pralatrexate
- Preparation Cleansing
- Ready-to-use Enema
- Rheumatrex
- rivaroxaban
- sod phos mono-sod phos dibasic
- sodium phosphates
- Trexall
- warfarin
- Xarelto
Severe
Moderate
- A-hydrocort
- A-methapred
- abciximab
- Accupril
- Accuretic
- Aceon
- adefovir
- Altace
- amiloride
- amiloride-hydrochlorothiazide
- amlodipine-benazepril
- amlodipine-olmesartan
- amlodipine-valsartan
- amlodipine-valsartan-hcthiazid
- Angeliq
- Anucort-hc
- Anusol-hc
- Aristospan Intra-articular
- Aristospan Intralesional
- Arixtra
- Astagraf Xl
- Atacand
- Atacand Hct
- Atripla
- Avalide
- Avapro
- azilsartan med-chlorthalidone
- azilsartan medoxomil
- Azor
- benazepril
- benazepril-hydrochlorothiazide
- Benicar
- Benicar Hct
- betamethasone acet & sod phos
- Beyaz
- Brilinta
- Brintellix
- Brisdelle
- budesonide
- bumetanide
- candesartan
- candesartan-hydrochlorothiazid
- captopril
- captopril-hydrochlorothiazide
- Celestone Soluspan
- Celexa
- cilostazol
- citalopram
- clopidogrel
- colchicine-probenecid
- Colocort
- Complera
- Cortef
- Cortenema
- Cortifoam
- cortisone
- Cozaar
- cyclosporine
- cyclosporine modified
- Cymbalta
- dalteparin (porcine)
- Demadex
- Depo-medrol
- desvenlafaxine
- desvenlafaxine fumarate
- desvenlafaxine succinate
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Diovan Hct
- drospirenone-e.estradiol-lm.FA
- drospirenone-estradiol
- drospirenone-ethinyl estradiol
- duloxetine
- Dyazide
- Dyrenium
- Edarbi
- Edarbyclor
- efavirenz-emtricitabin-tenofov
- Effexor Xr
- Elmiron
- elvitegr-cobicist-emtric-tenof
- emtricitab-rilpivirine-tenofov
- emtricitabine-tenofovir
- enalapril maleate
- enalapril-hydrochlorothiazide
- enalaprilat
- enoxaparin
- Entocort Ec
- Epaned
- eprosartan
- eprosartan-hydrochlorothiazide
- eptifibatide
- erlotinib
- escitalopram oxalate
- ethacrynate sodium
- Exforge
- Exforge Hct
- Ez Use Joint-tunnel-trigger
- Fetzima
- First-duke's
- First-mary's Mouthwash
- Flo-pred
- fludrocortisone
- fluoxetine
- fluvoxamine
- fondaparinux
- fosinopril
- fosinopril-hydrochlorothiazide
- Fragmin
- furosemide
- Gengraf
- Gianvi (28)
- Grx Hicort 25
- Hecoria
- Hemril-30
- heparin (porcine)
- heparin (porcine) in D5W
- heparin(porcine) in 0.45% NaCl
- heparin, porcine (PF)
- Hepsera
- hydrocortisone
- hydrocortisone acetate
- hydrocortisone sod succ (PF)
- hydrocortisone sod succinate
- Hyzaar
- Integrilin
- irbesartan
- irbesartan-hydrochlorothiazide
- Kenalog
- Khedezla
- Lasix
- levomilnacipran
- Lexapro
- lisinopril
- lisinopril-hydrochlorothiazide
- lithium carbonate
- lithium citrate
- Lithobid
- Loryna (28)
- losartan
- losartan-hydrochlorothiazide
- Lotensin
- Lotrel
- Lovenox
- Luvox Cr
- Mavik
- Maxzide
- Maxzide-25Mg
- Medrol
- Medrol (pak)
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- Micardis
- Micardis Hct
- Millipred
- Millipred Dp
- milnacipran
- moexipril
- moexipril-hydrochlorothiazide
- Neoral
- nystatin-hydrocortisone-diphen
- nystatin-TCN-HC-diphenhydramin
- Ocella
- olanzapine-fluoxetine
- olmesartan
- olmesartan-amlodipin-hcthiazid
- olmesartan-hydrochlorothiazide
- Orapred
- Orapred Odt
- paroxetine HCl
- paroxetine mesylate
- Paxil
- Paxil Cr
- Pediapred
- pentosan polysulfate sodium
- perindopril erbumine
- Pexeva
- Physicians Ez Use M-pred
- Plavix
- Pletal
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- Prinivil
- Pristiq
- probenecid
- Proctocort
- Prograf
- Prozac
- Prozac Weekly
- quinapril
- quinapril-hydrochlorothiazide
- ramipril
- Rapamune
- Rayos
- Rectacort-hc
- Reopro
- Safyral
- Sandimmune
- Sarafem
- Savella
- sertraline
- sirolimus
- Sodium Edecrin
- Solu-cortef
- Solu-cortef (pf)
- Solu-medrol
- Solu-medrol (pf)
- Stribild
- Syeda
- Symbyax
- tacrolimus
- Tarceva
- Tarka
- telmisartan
- telmisartan-amlodipine
- telmisartan-hydrochlorothiazid
- tenofovir disoproxil fumarate
- Teveten
- Teveten Hct
- ticagrelor
- torsemide
- trandolapril
- trandolapril-verapamil
- triamcinolone acetonide
- triamcinolone hexacetonide
- triamcinolone-lidocaine
- triamterene
- triamterene-hydrochlorothiazid
- Tribenzor
- Truvada
- Twynsta
- Uceris
- Uniretic
- Univasc
- valsartan-hydrochlorothiazide
- Vaseretic
- Vasotec
- venlafaxine
- Veripred 20
- Vestura (28)
- Viibryd
- vilazodone
- Viread
- vortioxetine
- Yasmin (28)
- Yaz 28
- Zarah
- Zestoretic
- Zestril
- Zoloft
- Aspirin exacerbated respiratory disease
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- History of roux-en-Y gastric bypass
- Post-operative from CABG surgery
- Pregnancy
Contraindicated
- Acute myocardial infarction
- Alcoholism
- Chronic heart failure
- Gastrointestinal hemorrhage
- Gastrointestinal perforation
- Gastrointestinal ulcer
- Increased cardiovascular event risk
- Increased risk of bleeding
- Increased risk of bleeding due to coagulation disorder
- Kidney disease with likely reduction in GFR
- Peptic ulcer
- Systemic mastocytosis
- Tobacco smoker
Severe
Moderate
- Disease of liver
- Gastritis
- Gastrointestinal ulcer
- Hypertension
NUDROXIPAK N-500 (nabumetone/capsaicin/methyl salicylate/menthol)
- None
- Acute abdominal pain
- Blistering skin
- Body fluid retention
- Contact dermatitis
- Diarrhea
- Dyspepsia
- Skin inflammation
More Frequent
Severe
Less Severe
- Edema
- Gastritis
- Skin rash
- Tinnitus
- Aphthous stomatitis
- Constipation
- Dizziness
- Drowsy
- Fatigue
- Flatulence
- Headache disorder
- Hyperhidrosis
- Insomnia
- Nausea
- Nervousness
- Pruritus of skin
- Vomiting
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute myocardial infarction
- Agranulocytosis
- Allergic dermatitis
- Anaphylaxis
- Anemia
- Angina
- Angioedema
- Aplastic anemia
- Black tarry stools
- Bloody stools
- Bloody vomit
- Blurred vision
- Bronchospastic pulmonary disease
- Bullous dermatitis
- Burns
- Cardiac arrhythmia
- Cerebrovascular accident
- Chest pain
- Chest tightness
- Depression
- Diplopia
- Duodenal ulcer
- Dyspnea
- Erythema multiforme
- Esophageal ulcer
- Exfoliative dermatitis
- Gastric ulcer
- Gastroenteritis
- Gastrointestinal hemorrhage
- Gastrointestinal perforation
- Gastrointestinal ulcer
- Glossitis
- Granulocytopenic disorder
- Hepatic failure
- Hepatitis
- Hyperkalemia
- Hypertension
- Hyperuricemia
- Hypokalemia
- Interstitial nephritis
- Interstitial pneumonitis
- Jaundice
- Laryngeal edema
- Leukopenia
- Loeffler syndrome
- Mood changes
- Nephrotoxicity
- Neutropenic disorder
- Pancreatitis
- Pancytopenia
- Peptic ulcer
- Pseudoporphyria
- Stevens-johnson syndrome
- Syncope
- Thrombocytopenic disorder
- Thrombophlebitis
- Toxic epidermal necrolysis
- Urticaria
- Vasculitis
- Visual changes
- Wheezing
Less Severe
- Acne vulgaris
- Acute confusion
- Agitation
- Altered mental status
- Anorexia
- Dysgeusia
- Dysphagia
- Fever
- General weakness
- Hyperglycemia
- Increased appetite
- Malaise
- Palpitations
- Paresthesia
- Proteinuria
- Skin photosensitivity
- Symptoms of anxiety
- Tremor
- Vertigo
- Weight gain
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Nabumetone
Safety and efficacy in pediatrics not established.
- 1 Day – 18 Years
- Safety and efficacy in pediatrics not established.
Nabumetone
- Severity Level:
1
- Additional Notes: Fda c;risk of early pregnancy miscarriage/premature closure of ductus arteriosus
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Capsaicin (topical)
Insufficient data available
Small amt of drug absorbed systemically;Risk of reye's syn w/oral salicylates
Insufficient human data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available |
Methyl Salicylate (topical/nasal)
Insufficient data available
Small amt of drug absorbed systemically;Risk of reye's syn w/oral salicylates
Insufficient human data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Small amt of drug absorbed systemically;Risk of reye's syn w/oral salicylates |
Nabumetone
Insufficient data available
Small amt of drug absorbed systemically;Risk of reye's syn w/oral salicylates
Insufficient human data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human data available |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- Nonsteroidal anti-inflammatory drugs (including nabumetone) may rarely increase the risk for a heart attack or stroke. This effect can happen at any time while taking this drug but is more likely if you take it for a long time. The risk may be greater if you have heart disease or increased risk for heart disease (for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes).<br /><br /> Do not take this drug right before or after heart bypass surgery (CABG). Also, this drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This effect can occur without warning symptoms at any time while taking this drug.<br /><br /> Older adults may be at higher risk for this effect. (See also Precautions and Drug Interactions sections.) Stop taking nabumetone and get medical help right away if you notice any of the following rare but serious side effects: bloody or black/tarry stools, persistent stomach/abdominal pain, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, weakness on one side of the body, sudden vision changes, slurred speech. Talk with your doctor or pharmacist about the risks and benefits of treatment with this medication.
Formulary Reference Tool