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PERPHENAZINE-AMITRIPTYLINE (PERPHENAZINE/AMITRIPTYLINE HCL)
- Anxiety with depression
2 mg-10 mg tablet
- 1 tablet by oral route 2 times per day
2 mg-25 mg tablet
- 1 tablet by oral route 2 times per day
4 mg-10 mg tablet
- 1 tablet by oral route 2 times per day
4 mg-25 mg tablet
- 1 tablet by oral route 2 times per day
4 mg-50 mg tablet
- 1 tablet by oral route 2 times per day
Anxiety with depression
- 1 tablet by oral route 3 times per day
- 1 tablet by oral route 4 times per day
- 2 tablets by oral route 4 times per day
- 2 tablets by oral route 3 times per day
- 1 tablet by oral route 2 times per day
- 2 tablets by oral route 2 times per day
- artemether-lumefantrine
- Azilect
- Coartem
- disopyramide
- dronedarone
- Eldepryl
- isocarboxazid
- linezolid
- Marplan
- Matulane
- methylene blue (antidote)
- metoclopramide HCl
- Metozolv Odt
- Multaq
- Nardil
- Norpace
- Norpace Cr
- Orap
- Parnate
- phenelzine
- pimozide
- procarbazine
- rasagiline
- Reglan
- selegiline HCl
- tranylcypromine
- Zelapar
- Zyvox
Contraindicated
- 12 Hour Nasal Relief Spray
- 12 Hour Nasal Spray
- Acta-tabs Pe
- Adderall
- Adderall Xr
- Adipex-p
- Adrenalin
- Adult Robitussin M-s Cold
- Adult Robitussin Night M-s Cld
- Adult Robitussin Peak Cold M-s
- Adult Tussin Multi-symp Cold
- Advil Allergy-congestion Rlf
- Advil Congestion Relief
- Afrin (oxymetazoline)
- Afrin Sinus
- Afrin Sinus No Drip
- Ala-hist Dm
- Ala-hist Pe
- albuterol sulfate
- Aldex D
- Aldex-ct
- Alka-seltzer Plus C/c(pe,dm)
- Alka-seltzer Plus Cold (pe)
- Alka-seltzer Plus Cold/cough
- Alka-seltzer Plus Day
- Alka-seltzer Plus Day-night
- Alka-seltzer Plus Flu
- Alka-seltzer Plus Night
- Alka-seltzer Plus Sin-allg-cgh
- Alka-seltzer Plus Sinus-cough
- Allergy M-s Nighttime
- Allergy Multi-symptom
- Allergy Plus Severe Sinus Ha
- Allergy Relief Multi-symptom
- Allergy Relief(chlorphen-acet)
- Allergy Relief-sinus Headache
- Allergy Sinus Headache
- Allergy Sinus Pe
- Allergy-d
- Allergy-sinus
- Altipres
- Altipres Pediatric
- Altipres-b
- Ambi 10Peh-4Cpm
- Ambi 10Peh-4Cpm-20Dm
- Amphetamine Salt Combo
- Anefrin
- Ap-hist Dm
- Apokyn
- apomorphine
- Balamine Dm
- benzphetamine
- Bio T Pres
- Bio T Pres Pediatric
- Bio T Pres-b
- Bio-b Kids
- Bio-s-pres Dx
- Biobron Dx
- Biobron Sf
- Biocotron-d
- Biodesp Dm
- Biogil
- Biogtuss Nf
- Bionatuss Dxp
- Bontril Pdm
- Brohist D
- brompheniramin-phenylephrin-DM
- brompheniramine-PE-chlophedian
- brompheniramine-PE-codeine
- brompheniramine-phenylephrine
- Bronchial Asthma Relief
- Broncotron Ped
- Bronkaid Dual Action
- Bronkids
- Brontuss Sf
- Brovex Peb
- Brovex Peb Dm
- bupivacaine-epinephrine
- bupivacaine-epinephrine (PF)
- bupivacaine-epinephrine bitart
- cabergoline
- Capcof
- Carbaphen Ch
- Carbaphen Ped Ch
- carbidopa-levodopa
- carbidopa-levodopa-entacapone
- Cardec
- Cardec Dm
- Ccp Caffeine Free
- Centergy
- Centergy Dm
- Chest Congestion Relief Pe
- Chest-sinus Congestion Relief
- Child Delsym Cough+cold
- Child Dometuss-da
- Child Mucinex Congestion-cough
- Child Mucinex Stuffy Nose-cold
- Child Multi-symptom Cold/cough
- Child Wal-tap Cold-allergy
- Child's Benadryl-d Allergy-sin
- Child's Mucus Relief M-s Cold
- Children Night Time Cold-cough
- Children's Cold & Allergy
- Children's Cold & Cough
- Children's Cold & Cough Dm
- Children's Cold-cough-sore
- Children's Dibromm Cold & Alle
- Children's Dibromm Dm Cold & C
- Children's Dimetapp Cold &Flu
- Children's Flu Relief
- Children's Mucinex Cold-fever
- Children's Mucinex Multi-symp
- Children's Mucinex Night Time
- Children's Plus Flu
- Children's Sudafed Pe Cough
- Children's Sudafed Pe Nasal
- Childrens Plus Cold
- Childs Plus Cold & Allergy
- Childs Triacting Cold & Cough
- chlorcyclizine-phenylephrine
- chlorphen-PE-DM-acetaminophen
- chlorphen-phenyleph-DM-aspirin
- chlorphen-phenyleph-ibuprofen
- chlorphenir-phenylephrn-aspirn
- chlorpheniram-PE-chlophedianol
- chlorpheniramine-PE-codeine
- chlorpheniramine-phenyleph-DM
- chlorpheniramine-phenylephrine
- Codituss Dm
- Cold & Allergy
- Cold & Allergy Pe
- Cold & Cough
- Cold & Cough Dm
- Cold & Cough Elixir
- Cold & Flu Severe
- Cold Head Congestion
- Cold Head Congestion Day/nite
- Cold Multi-symptom
- Cold Multi-symptom Day/night
- Cold Multi-symptom Daytime
- Cold Multi-symptom Nighttime
- Cold Relief
- Cold Relief M/s Day/night
- Cold Relief Plus
- Cold Severe Congestion
- Cold-cough Sinus Relief Pe
- Cold-flu Relief
- Cold-flu Relief, Day/night
- Complete Sinus Relief
- Comtan
- Concerta
- Congest-eze Pe
- Contac Cold-flu Day And Night
- Contac Cold-flu Max Strength
- Conzip
- Cough & Cold
- Cough & Cold Mucus Relief Cf
- Cough & Severe Cold
- cpm-phenyleph-acetaminophen
- Dallergy (chlorcyclizine-pe)
- Dallergy (chlorpheniramine-pe)
- Dallergy (dexbrompheniramn-pe)
- Day Time Pe
- Daytime
- Daytime & Nighttime Cold
- Daytime & Nitetime Sinus
- Daytime Cold & Flu Relief
- Daytime Cold-flu
- Daytime Sinus
- Daytime-nighttime
- Daytime-nighttime Cold-flu
- Daytrana
- Deconex Dmx
- Deconex Ir
- Decorel Forte Plus
- Delsym Cough+cold Daytime
- Delsym Cough+cold Nighttime
- Desgen
- Desgen Dm
- Desoxyn
- Despec
- Despec Eda Cough & Cold Drops
- Despec-dm
- dexbromphen-phenyleph-acetamin
- dexbrompheniramine-phenylep-DM
- dexbrompheniramine-phenyleph
- dexchlorphen-phenyleph-codeine
- dexchlorpheniram-phenylephrine
- Dexedrine Spansule
- dexmethylphenidate
- dextroamphetamine
- dextroamphetamine-amphetamine
- dextromethorphan-quinidine
- Didrex
- diethylpropion
- Dimaphen (pe)
- Dimaphen Dm
- Dimetapp Cold-allergy (pe)
- Dimetapp Cold-congestion
- Dimetapp Dm Cold-cough (pe)
- diphenhy HCl-PE-DM-acetamin-GG
- diphenhyd-PE-acetaminophen
- diphenhyd-PE-DM-acetaminophen
- diphenhydram-PE-acetaminoph-GG
- diphenhydramine-phenylephrine
- DM-PE-acetam/DM-acetam-doxylam
- dobutamine
- dobutamine in D5W
- Dometuss G
- Dometuss-dmx
- Donatussin Pediatric
- dopamine
- dopamine in D5W
- doxylam-PE-DM-acetaminophen-GG
- doxylam-phenylephrine-acetamin
- doxylamine-PE-DM-acetaminophen
- doxylamine-phenylep-DM-aspirin
- doxylamine-phenylephrine
- Dristan Cold
- Dristan Long Lasting
- Duravent Dm
- Duravent Pe
- Ed A-hist
- Ed A-hist Dm
- Ed Bron Gp
- Ed Chlorped D
- Effervescent Cold Relief Plus
- Endacof - Dm
- Endacon
- entacapone
- Entex Lq
- Entre-b
- ephedrine sulfate
- ephedrine sulfate-guaifenesin
- ephedrine-guaifenesin
- epinephrine
- epinephrine (PF)
- Exactuss
- Fareston
- Fenesin Pe Ir
- Flu & Severe Cold-daytime
- Flu & Severe Cold-nighttime
- Flu & Sore Throat
- Flu & Sore Throat Relief
- Flu Formula Daytime-nighttime
- Flu Relief Therapy Cold-chest
- Flu Relief Therapy Daytime
- Flu Relief Therapy Nighttime
- Flu-severe Cold-cough
- Focalin
- Focalin Xr
- G-p-tuss Dxp
- G-supress Dx
- G-tron Ped
- G-tusicof
- Gilphex Tr
- Giltuss
- Giltuss Pediatric
- Giltuss Tr
- Head Congestion Cold Relief
- Histex Dm
- Histex Pe
- ibuprofen-phenylephrine HCl
- Intense Cold & Flu
- isometh-dichloral-acetaminophn
- isomethepten-caf-acetaminophen
- isoproterenol HCl
- Isuprel
- J-max
- levmetamfetamine
- Levophed (bitartrate)
- lidocaine-epinephrine
- lidocaine-epinephrine (PF)
- lidocaine-epinephrine bit
- Liquibid D-r
- Liquibid Pd-r
- lisdexamfetamine
- lithium carbonate
- lithium citrate
- Lithobid
- Lohist Peb Dm
- Lohist-dm
- Lohist-peb
- Long Acting Nasal Spray
- M-end Pe
- Mapap Cold Formula
- Mapap Sinus Max Strength (pe)
- Marcaine-epinephrine
- Marcaine-epinephrine (pf)
- Maxiphen
- Maxiphen Dm
- Maxiphen Dmx
- Medi-phenyl
- Medicidin-d
- Metadate Cd
- Metadate Er
- metaproterenol
- methamphetamine
- Methylin
- methylphenidate
- midodrine
- Migragesic Ida
- Mirapex
- Mirapex Er
- Mucaphed
- Mucinex Cold & Sinus
- Mucinex Cold-flu & Sore Throat
- Mucinex Fast-max Cold-flu
- Mucinex Fast-max Cold-sinus
- Mucinex Fast-max Congest-cold
- Mucinex Fast-max Congest-cough
- Mucinex Fast-max Nite Cold-flu
- Mucinex Sinus-max Day-night
- Mucinex Sinus-max Pressur-pain
- Mucinex Sinus-max Sev Congest
- Mucus Relief
- Mucus Relief Cold & Sinus
- Mucus Relief Cold-flu-sore Thr
- Mucus Relief D (phenylephrine)
- Mucus Relief Pe
- Mucus Relief Plus
- Mucus Relief Sev Congest-cold
- Mucus Relief Sinus
- Multi-symptom Cold (pe & Cpm)
- Multi-symptom Cold (pe)
- Multi-symptom Cold Daytime
- Multi-symptom Cold Night Time
- Nasal Decongestant (oxymetazl)
- Nasal Decongestant (pe)
- Nasal Relief
- Nasal Spray (oxymetazoline)
- Nasal Spray 12 Hour
- Nasal Spray 12 Hour Sinus
- Nasal Spray Extra Moisturizing
- Nasal Spray Long Acting
- Nasal Spray Moisturizing
- Nasal Spray Sinus
- Nasal Spray X-moist
- Nasohist
- Nasohist Dm
- Nasopen Pe
- Neo-synephrine (phenylephrine)
- Neo-synephrine 12 H Spr (oxym)
- Neotuss Plus
- Neotuss-d (improved Formula)
- Night Time Cold
- Nighttime Cough-cold
- Nighttime Sinus
- No Drip
- No Drip Nasal Relief
- Nodolor
- Nohist-dm
- Nohist-lq
- Non-aspirin Severe Congest M-s
- Non-aspirin Sinus
- Non-drying Sinus
- Non-pseudo Cold Relief
- Non-pseudo Sinus Pain-pressure
- Norel Ad
- Norel Cs
- norepinephrine bitartrate
- Nose Spray
- Nrs Nasal Relief
- Nu-copd
- Nucynta
- Nucynta Er
- Nuedexta
- Original Nasal Spray
- oxymetazoline
- Pain Relief Allergy Sinus
- Pain Relief Cold
- Pain Relief Sinus Pe
- PE-acetam/doxylamine-PE-acetam
- PE-DM-ASA/doxyla-PE-DM-ASA
- Pediacare Decongestant (pe)
- Pediacare Multi-symptom Cold
- Phenabid Dm
- Phenagil
- Phenagil Ch
- phendimetrazine tartrate
- pheniramine-phenyleph-acetamin
- phentermine
- phentermine-topiramate
- phenyleph-DM-acetamin-guaifen
- phenylephrine HCl
- phenylephrine-acetaminophen
- phenylephrine-acetaminophen-GG
- phenylephrine-chlophedianol-GG
- phenylephrine-DM
- phenylephrine-DM-acetaminophen
- phenylephrine-DM-guaifenesin
- phenylephrine-guaifenesin
- phenylephrine-pyrilamine
- Poly Hist Forte (doxylamine)
- Poly-hist Dm (thonzylamine)
- Poly-tussin Ac
- pramipexole
- Pres Gen
- Pres Gen Pediatric
- Presgen B
- Pressure & Pain
- Primatene Asthma
- Pro-chlo
- Pro-red Ac (w/ Dexchlorphenir)
- Procentra
- Prodrin
- Promethazine Vc
- Promethazine Vc-codeine
- promethazine-phenyleph-codeine
- promethazine-phenylephrine
- pyrilamine-PE-chlophedianol
- pyrilamine-phenylephrine-DM
- Pyrroxate Cold & Congest
- Qsymia
- Quillivant Xr
- quinidine gluconate
- quinidine sulfate
- Refenesen Pe
- Regimex
- Requip
- Requip Xl
- Rescon-gg
- Ritalin
- Ritalin La
- Ritalin Sr
- Robafen Cf
- Robitussin Cold-flu Day
- Robitussin Cough & Cold Cf
- ropinirole
- Ru-hist D
- Ru-hist-d (with Pyrilamine)
- Rymed
- Rynex Dm
- Rynex Pe
- Sensorcaine-mpf/epinephrine
- Sensorcaine/epinephrine
- Severe Allergy-sinus Headache
- Severe Cold
- Severe Cold (diphen-pe-acetam)
- Severe Cold Multi-symptom
- Severe Cold Pe
- Severe Congestion
- Severe Congestion & Cough Max
- Sinemet
- Sinemet Cr
- Sinex Ultra Fine Mist 12-hour
- Sinus & Allergy
- Sinus & Allergy Pe
- Sinus Cong & Pain Day-night
- Sinus Congestion & Pain
- Sinus Daytime-nightime
- Sinus Decongestant (pe)
- Sinus Formula Daytime
- Sinus Headache Pe
- Sinus Maximum Strength
- Sinus Nasal Spray
- Sinus Nighttime
- Sinus Pain Relief
- Sinus Relief (non-drowsy)
- Sinus Relief (oxymetazoline)
- Sinutrol Pe
- sodium oxybate
- Stalevo 100
- Stalevo 125
- Stalevo 150
- Stalevo 200
- Stalevo 50
- Stalevo 75
- Sudafed Pe Pressure+pain+cold
- Sudafed Pe Pressure+pain+cough
- Sudogest Pe
- Suphedrine Pe
- Suphedrine Pe Cold & Allergy
- Suphedrine Pe Day-night
- Suphedrine Pe Sinus & Allergy
- Suphedrine Pe Sinus Headache
- Suprenza
- Supress A
- Supress Dx
- Supress-pe
- Synapryn
- tapentadol
- terbutaline
- tetrahydrozoline
- Tg 10Peh-380Gfn
- Tg 10Peh-380Gfn-15Dm
- Theraflu Daytime Cold-cough
- Theraflu Flu-sore Throat
- Theraflu Multi-symptom Cold
- Theraflu Nighttime Cold-cough
- thioridazine
- thonzylamine-phenyl-chlophed
- thonzylamine-phenylephrine
- thonzylamine-phenylephrine-DM
- Tl-hist Dm
- toremifene
- tramadol
- tramadol-acetaminophen
- tramadol-glucosamine
- Trexbrom
- Tri-dex Pe
- Triaminic Cold & Cough (pe)
- Triaminic Cold & Cough Nt (pe)
- Triaminic Cold- Allergy Pe
- Trigofen Dm
- triprolidine-phenylephrine
- triprolidine-phenylephrine-DM
- Tusicof
- Tussi Pres-b
- Tussi-pres
- Tussi-pres Pediatric
- Tussin Cf
- Tussin Cf Cough-cold
- Tussin Cf Max
- Tussin Cough-cold-flu
- Tussin Pe
- Tusslin
- Tylenol Cold & Flu Severe
- Tylenol Cold Head Congest Sevr
- Tylenol Cold Multi-sympt Night
- Tylenol Cold Multi-symptom Day
- Tylenol Sinus Congestion Pain
- Tyzine
- Ultracet
- Ultram
- Ultram Er
- Vanacof Ape
- Vanacof Dm
- Vanacof Gpe
- Vapor Inhaler
- Vazobid-pd
- Vazotab (pyrilamine)
- Vicks Dayquil
- Vicks Dayquil Cold&Flu Relief
- Vicks Dayquil Severe Cold-flu
- Vicks Dayquil Sinex
- Vicks Dayquil-nyquil
- Vicks Dayquil-nyquil Cold-flu
- Vicks Dayquil-nyquil Severe
- Vicks Nature Fusion
- Vicks Nyquil Severe Cold-flu
- Vicks Nyquil Sinex
- Vicks Sinex 12-hour
- Virdec
- Virdec Dm
- Vospire Er
- Vyvanse
- Wal-dryl Severe Allergy-sinus
- Wal-dryl-d Allergy & Sinus
- Wal-flu Night Severe Cold
- Wal-flu Night Time
- Wal-flu Severe Cold
- Wal-flu Severe Cold-cough
- Wal-phed Pe
- Wal-phed Pe Cold-cough
- Wal-phed Pe Nighttime Cold
- Wal-phed Pe Severe Cold
- Wal-phed Pe Sinus & Allergy
- Wal-tap
- Wal-tap Dm
- Wal-tussin Cough & Cold Cf
- Xylocaine-epinephrine
- Xylocaine-mpf/epinephrine
- Xyrem
- Zenzedi
Severe
Moderate
- Acid Reducer (cimetidine)
- Acid Relief (cimetidine)
- Advair Diskus
- Advair Hfa
- Alagesic Lq
- amobarbital
- Amytal
- Anaspaz
- Anoro Ellipta
- Aplenzin
- Arcapta Neohaler
- arformoterol
- Ascomp With Codeine
- Atropen
- atropine
- B cplx-C-St.Johnwrt-K.&S.ginsg
- belladonna alkaloids-opium
- Belladonna-opium
- Belladonna-phenobarbital
- Bentyl
- benztropine
- Breo Ellipta
- Brisdelle
- Bronchial Mist
- Bronchial Mist Refill
- Brovana
- budesonide-formoterol
- Bupap
- Buproban
- bupropion HBr
- bupropion HCl
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- calcium-mag-B complex-D3-hrb61
- Cantil
- Capacet
- Catapres
- Catapres-tts-1
- Catapres-tts-2
- Catapres-tts-3
- Celexa
- chlordiazepoxide-clidinium
- chlorphen-pseudoeph-bellad alk
- cimetidine
- cinacalcet
- citalopram
- clonidine
- clonidine (PF)
- clonidine-chlorthalidone
- Clorpres
- codeine-butalbital-ASA-caff
- Cogentin
- Cold & Flu Fighter
- Combivent Respimat
- Cuvposa
- Cymbalta
- Depacon
- Depakene
- Depakote
- Depakote Er
- Depakote Sprinkles
- desvenlafaxine
- desvenlafaxine fumarate
- desvenlafaxine succinate
- dicyclomine
- Diflucan
- diphenoxylate-atropine
- Ditropan Xl
- divalproex
- Donnatal
- Dulera
- duloxetine
- Duodote
- Duoneb
- Duraclon (pf)
- Ed-spaz
- edrophonium Cl-atropine
- Effexor Xr
- Enlon-plus
- epinephrine base (refill)
- escitalopram oxalate
- Esgic
- Fatigue Relief Complex
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- flavoxate
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fluoxetine
- fluticasone-salmeterol
- fluticasone-vilanterol
- fluvoxamine
- Foradil Aerolizer
- Forfivo Xl
- formoterol fumarate
- fosamprenavir
- Gelnique
- Glycate
- glycopyrrolate
- Heartburn Relief
- Hydrocodone Compound
- hydrocodone-homatropine
- Hydromet
- Hyophen
- hyoscyamine sulfate
- Hyosyne
- indacaterol
- ipratropium-albuterol
- Kapvay
- Khedezla
- Lamisil
- levalbuterol HCl
- levalbuterol tartrate
- Levbid
- Levsin
- Levsin/sl
- Lexapro
- Lexiva
- Librax (with Clidinium)
- Lomotil
- Luminal
- Luvox Cr
- Margesic
- Marten-tab
- mepenzolate bromide
- methen-hyos-me blue-ba-salicyl
- methen-hyosc-m.blue-sal-naphos
- methen-sod phos-meth blue-hyos
- methscopolamine
- mometasone-formoterol
- mth-me blue-sod phos-phsal-hyo
- Mysoline
- Nembutal Sodium
- Nulev
- olanzapine-fluoxetine
- Oscimin
- Oscimin Sl
- Oscimin Sr
- oxybutynin
- oxybutynin chloride
- Oxytrol
- Oxytrol For Women
- Pamine
- Pamine Forte
- paroxetine HCl
- paroxetine mesylate
- Paxil
- Paxil Cr
- pentobarbital sodium
- Perforomist
- Pexeva
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phosphasal
- pralidoxime-atropine
- primidone
- Pristiq
- Proair Hfa
- propantheline
- Prosed/ds (atropine Free)
- Proventil Hfa
- Prozac
- Prozac Weekly
- Respa-ar
- Robinul
- Robinul Forte
- salmeterol
- Sarafem
- scopolamine base
- scopolamine HBr
- secobarbital sodium
- Seconal Sodium
- Sensipar
- Serevent Diskus
- sertraline
- St. John's wort
- Stavzor
- Symax Duotab
- Symax Fastabs
- Symax-sl
- Symax-sr
- Symbicort
- Symbyax
- Tagamet Hb
- Tencon
- terbinafine
- Transderm-scop
- trihexyphenidyl
- Tussigon
- umeclidinium-vilanterol
- Ur N-c
- Urelle
- Uretron D-s
- Uribel
- Urimar-t
- Urin Ds
- Urogesic-blue
- Uryl
- Ustell
- Uta
- valproate sodium
- valproic acid
- valproic acid (as sodium salt)
- venlafaxine
- Ventolin Hfa
- vit C-St. John wort-elder-hb30
- Wellbutrin
- Wellbutrin Sr
- Wellbutrin Xl
- Women's Complex
- Xopenex
- Xopenex Concentrate
- Xopenex Hfa
- Zebutal
- Zoloft
- Zyban
- 30 day risk period post-myocardial infarction
- Angle-closure glaucoma
- Coma
- Neuroleptic malignant syndrome
- Stupor
Contraindicated
- Acute myocardial infarction
- Alcoholism
- Benign prostatic hyperplasia with lower urinary tract sx
- Carcinoma of breast
- Cardiac arrhythmia
- Chronic idiopathic constipation
- Congenital long QT syndrome
- Disease of liver
- Extrapyramidal disease
- Glaucoma
- Mania associated with bipolar disorder
- Metabolic syndrome X
- Myocardial ischemia
- Organophos insecticide poisoning
- Orthostatic hypotension
- Paralytic ileus
- Prolonged QT interval
- Senile dementia
- Suicidal ideation
- Tardive dyskinesia
- Torsades de pointes
- Urinary retention
Severe
Moderate
- Alcoholism
- Anemia
- Angina
- Benign prostatic hyperplasia
- Bradycardia
- Chronic disease of respiratory system
- Chronic heart failure
- CYp2d6 poor metabolizer
- Disease of liver
- Hyperglycemia
- Hyperprolactinemia
- Hyperthyroidism
- Leukopenia
- Neutropenic disorder
- Obesity
- Open angle glaucoma
- Orthostatic hypotension
- Parkinsonism
- Predisposition to aspiration
- Seizure disorder
- Sinus tachycardia
- Thrombocytopenic disorder
- Weight gain
PERPHENAZINE-AMITRIPTYLINE (PERPHENAZINE/AMITRIPTYLINE HCL)
- Anxiety with depression
- Akathisia
- Blurred vision
- Extrapyramidal disease
- Hypotension
- Pigmentary retinopathy
- Syncope
- Tardive dyskinesia
- Constipation
- Decreased sweating
- Dizziness
- Drowsy
- Dysgeusia
- Headache disorder
- Increased appetite
- Nasal congestion
- Orthostatic hypotension
- Sialorrhea
- Weight gain
- Xerostomia
More Frequent
Severe
Less Severe
- Abnormal sexual function
- Acute confusion
- Blurred vision
- Bradycardia
- Cardiac arrhythmia
- Contact dermatitis
- Dysuria
- Erectile dysfunction
- Hallucinations
- Hypotension
- Nervousness
- Parkinsonism
- Skin photosensitivity
- Tremor
- Abnormal sexual function
- Breast engorgement
- Constipation
- Diarrhea
- Galactorrhea not associated with childbirth
- Heartburn
- Hyperhidrosis
- Insomnia
- Irregular menstrual periods
- Libido changes
- Mastalgia
- Vomiting
- Weight gain
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal ECG
- Abnormal hepatic function tests
- Accidental fall
- Acute myocardial infarction
- Agranulocytosis
- Allergic dermatitis
- Alopecia
- Angioedema
- Blood dyscrasias
- Cerebrovascular accident
- Drug-induced psychosis
- Eosinophilia
- Galactorrhea not associated with childbirth
- Gynecomastia
- Heart block
- Heat stroke
- Hyperbilirubinemia
- Hypothermia
- Leukopenia
- Melanosis
- Neuroleptic malignant syndrome
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Panic disorder
- Priapism
- Prolonged QT interval
- Pruritus of skin
- Purpura
- Secondary angle-closure glaucoma
- Seizure disorder
- Serotonin syndrome
- SIADH syndrome
- Skin photosensitivity
- Skin rash
- Suicidal ideation
- Tachycardia
- Testicular swelling
- Tinnitus
- Torsades de pointes
- Ventricular fibrillation
- Ventricular tachycardia
- Visual changes
Less Severe
- Aggressive behavior
- Agitation
- Akathisia
- Anorexia
- Delusional disorder
- Facial edema
- Fever
- Hostility
- Hyperglycemia
- Hypertension
- Hypoglycemic disorder
- Hypomania
- Impulse control disorder
- Irritability
- Manic disorder
- Mydriasis
- Nausea
- Nightmares
- Palpitations
- Paresthesia
- Photophobia
- Symptoms of anxiety
Contraindicated
None
Severe Precaution
Amitriptyline
Possible increased suicidal ideation and attempt with underlying major depression.
Not recommended for pediatrics under 12 years of age.
- 1 Day – 18 Years
- Possible increased suicidal ideation and attempt with underlying major depression.
- 1 Day – 12 Years
- Possible increased suicidal ideation and attempt with underlying major depression.
Perphenazine
Possible increased suicidal ideation and attempt with underlying major depression.
Not recommended for pediatrics under 12 years of age.
- 1 Day – 18 Years
- Not recommended for pediatrics under 12 years of age.
- 1 Day – 12 Years
- Not recommended for pediatrics under 12 years of age.
Management or Monitoring Precaution
None
Amitriptyline
- Severity Level:
C
- Additional Notes: Use w/caution;active metabolite nortriptyline may cause infant urinary retention
Perphenazine
- Severity Level:
2
- Additional Notes: No fda category; neonate complications(resp,gi,cns) w/exposure in 3rd trimester
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Amitriptyline
Insufficient human data available; low levels excreted
Low amnt excr w/similar drug chlorpromazine, resulting in infant drowsiness
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Insufficient human data available; low levels excreted |
Perphenazine
Insufficient human data available; low levels excreted
Low amnt excr w/similar drug chlorpromazine, resulting in infant drowsiness
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Low amnt excr w/similar drug chlorpromazine, resulting in infant drowsiness |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
Amitriptyline
General-lower doses recommended if use required, 50 mg may be sufficient for MDD. Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Cardiovascular-May cause orthostatic hypotension at higher doses. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause. Endocrine-Increased risk for hyponatremia due to SIADH.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | Y | Y | Y | N | Y |
BEERS: Y HEDIS: Y STOPP: Y
Precaution Exists
Amitriptyline (10-25 Mg)
General-lower doses recommended, 10-20 mg may be sufficient for sleep. Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Cardiovascular-May cause orthostatic hypotension at higher doses. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
Neuro/Psych-Inc risk of tardive dyskinesia. CNS effects; sedation, cognitive impair and inc fall risk. Avoid use for behav probs of dementia or delirium unless failed nonpharm options. Inc risk of stroke, cognit decline, and death when used w/senile dementia. Max 8mg/day. Endocrine-May exacerbate or cause SIADH or hyponatremia. Cardiovascular-May cause orthostatic hypotens at higher doses. Gastrointestinal-May cause or worsen constipation. Genitourinary-Avoid in pts w/urinary reten.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | Y | Y | N | N | Y |
BEERS: Y HEDIS: Y STOPP: Y
Perphenazine
General-lower doses recommended, 10-20 mg may be sufficient for sleep. Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Cardiovascular-May cause orthostatic hypotension at higher doses. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
Neuro/Psych-Inc risk of tardive dyskinesia. CNS effects; sedation, cognitive impair and inc fall risk. Avoid use for behav probs of dementia or delirium unless failed nonpharm options. Inc risk of stroke, cognit decline, and death when used w/senile dementia. Max 8mg/day. Endocrine-May exacerbate or cause SIADH or hyponatremia. Cardiovascular-May cause orthostatic hypotens at higher doses. Gastrointestinal-May cause or worsen constipation. Genitourinary-Avoid in pts w/urinary reten.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | Y | Y | N | Y |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts.<br /><br />Therefore, it is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.<br /><br /> There may be a slightly increased risk of serious, possibly fatal side effects (such as stroke, heart failure, fast/irregular heartbeat, pneumonia) when this medication is used by older adults with dementia. This medication is not approved for the treatment of dementia-related behavior problems. Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor.
| Anxiety with depression | |
| F41.8 | Other specified anxiety disorders |
| 0-9 | A-Z |
|---|---|
| F41.8 | Other specified anxiety disorders |
Formulary Reference Tool