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CAPTOPRIL-HYDROCHLOROTHIAZIDE (CAPTOPRIL/HYDROCHLOROTHIAZIDE)
- Hypertension
captopril 25 mg-hydrochlorothiazide 15 mg tablet
- 1 tablet by oral route 2 times per day
captopril 25 mg-hydrochlorothiazide 25 mg tablet
- 1 tablet by oral route 2 times per day
captopril 50 mg-hydrochlorothiazide 15 mg tablet
- 1 tablet by oral route 2 times per day
captopril 50 mg-hydrochlorothiazide 25 mg tablet
- 1 tablet by oral route 2 times per day
Hypertension
- 1 tablet by oral route 3 times per day
- 1 tablet by oral route once daily
- 1 tablet by oral route 2 times per day
- 2 tablets by oral route once daily
- dofetilide
- Tikosyn
Contraindicated
- aliskiren
- aliskiren-amlodipin-hcthiazide
- aliskiren-amlodipine
- aliskiren-hydrochlorothiazide
- Amturnide
- Curad Enema
- Disposable Enema
- Enema
- Enema Disposable
- Fleet Enema
- Fleet Enema Extra
- Fleet Pediatric
- Hycamtin
- lithium carbonate
- lithium citrate
- Lithobid
- methenamine mand-sod biphos
- Oral Saline Laxative
- Osmoprep
- Phosphate Laxative
- Preparation Cleansing
- Ready-to-use Enema
- Reclast
- sod phos mono-sod phos dibasic
- sodium phosphates
- Tekamlo
- Tekturna
- Tekturna Hct
- topotecan
- Uroqid-acid No.2
- zoledronic acid
- zoledronic acid-mannitol-water
- Zometa
Severe
Moderate
- acarbose
- Added Strength Headache Relief
- Added Strength Pain Reliever
- Alka-seltzer
- Alka-seltzer Extra Strength
- Alka-seltzer Original
- Alka-seltzer Plus C/c(pe,dm)
- Alka-seltzer Plus Cold (pe)
- Alka-seltzer Plus Day-night
- Alka-seltzer Plus Night
- Alka-seltzer Pm
- Amaryl
- Anacin
- Anacin Maximum Strength
- Analgesic
- Angeliq
- Antacid & Pain Relief
- Apidra
- Apidra Solostar
- ASA-acetaminophen-caff-buffers
- ASA-acetaminophen-salicyl-caff
- Ascomp With Codeine
- Aspir-trin
- aspirin
- aspirin, buffered
- aspirin-acetaminophen-caffeine
- aspirin-caffeine
- aspirin-diphenhydramine
- aspirin-diphenhydramine citrat
- aspirin-sod bicarb-citric acid
- Azasan
- azathioprine
- azathioprine sodium
- Back & Body Pain Reliever
- Bactrim
- Bactrim Ds
- Bayer Advanced
- Bayer Aspirin
- Bayer Aspirin (with Caffeine)
- Bayer Back & Body
- Bayer Plus Extra Strength
- Bayer Pm
- Bc
- Bc Arthritis
- Beyaz
- Buffered Aspirin
- Bufferin
- bumetanide
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-aspirin-caffeine
- carisoprodol-ASA-codeine
- carisoprodol-aspirin
- chlorphen-phenyleph-DM-aspirin
- chlorphenir-phenylephrn-aspirn
- cholestyramine (with sugar)
- Cholestyramine Light
- cholestyramine-aspartame
- codeine-butalbital-ASA-caff
- Cold Relief
- Cold Relief Plus
- Colestid
- Colestid Flavored
- colestipol
- Demadex
- Diabeta
- diazoxide
- Digox
- digoxin
- dihydrocodeine-aspirin-caff
- doxylamine-phenylep-DM-aspirin
- drospirenone-e.estradiol-lm.FA
- drospirenone-estradiol
- drospirenone-ethinyl estradiol
- Duetact
- E.c. Prin
- Ecotrin
- Efferves Pain Relief Antacid
- Effervescent Antacid
- Effervescent Pain Relief
- Effervescent Pain Reliever
- Endodan
- ethacrynate sodium
- Excedrin Extra Strength
- Excedrin Migraine
- Extra Strength Bayer
- Fiorinal
- Fiorinal-codeine #3
- furosemide
- Gianvi (28)
- glimepiride
- glipizide
- glipizide-metformin
- Glucotrol
- Glucotrol Xl
- Glucovance
- glyburide
- glyburide micronized
- glyburide-metformin
- Glynase
- Glyset
- Goody's Extra Strength
- Goody's Migraine Relief
- Headache Formula
- Headache Formula Added Str
- Headache Relief
- Humalog
- Humalog Kwikpen
- Humalog Mix 50-50
- Humalog Mix 50-50 Kwikpen
- Humalog Mix 75-25
- Humalog Mix 75-25 Kwikpen
- Humulin 70/30
- Humulin N
- Humulin N Kwikpen
- Humulin R
- Humulin R U-500 "Concentrated"
- Imuran
- insulin asp prt-insulin aspart
- insulin aspart
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin lispro
- insulin lispro protam-lispro
- insulin NPH and regular human
- insulin regular hum U-500 conc
- insulin regular human
- Lanoxin
- Lanoxin Pediatric
- Lantus
- Lantus Solostar
- Lasix
- Levacet
- Levemir
- Levemir Flexpen
- Lite Coat Aspirin
- Loryna (28)
- Medi-seltzer
- mercaptopurine
- miglitol
- Migraine Formula
- Migraine Pain Reliever
- Migraine Relief
- nateglinide
- Novolin 70/30
- Novolin N
- Novolin R
- Novolog
- Novolog Flexpen
- Novolog Mix 70-30
- Novolog Mix 70-30 Flexpen
- Novolog Penfill
- NPH insulin human recomb
- Ocella
- Orphenadrine Compound Forte
- Orphenadrine Compound-ds
- orphenadrine-ASA-caffeine
- oxycodone-aspirin
- Pain Relief
- Pain Relief Extra Strength
- Pain Reliever
- Pain Reliever Extra Strength
- Pain Reliever Plus
- Pain-off
- Pamprin Max
- PE-DM-ASA/doxyla-PE-DM-ASA
- Percodan
- pioglitazone-glimepiride
- Precose
- Prevalite
- Primsol
- Proglycem
- Purinethol
- Questran
- Questran Light
- Safyral
- Sodium Edecrin
- Starlix
- sulfamethoxazole-trimethoprim
- Sulfatrim
- Super Pain Relief
- Syeda
- Synalgos-dc
- tolazamide
- tolbutamide
- torsemide
- Tri-buffered Aspirin
- trimethoprim
- Vanquish
- Vestura (28)
- Yasmin (28)
- Yaz 28
- Zarah
- Angioedema
- Anuria
- Hypotension
- Pregnancy
Contraindicated
- Acute pancreatitis
- Azotemia
- Dehydration
- Gout
- Hemodialysis with high-flux membrane
- Hepatic failure
- Hereditary angioedema
- Hyperkalemia
- Hyperuricemia
- Hypochloremic alkalosis
- Hypokalemia
- Hypomagnesemia
- Hyponatremia
- Hypovolemia
- Neonatal hyperbilirubinemia
- Secondary angle-closure glaucoma
Severe
Moderate
- Aortic valve stenosis
- Basal cell carcinoma of skin
- Bone marrow depression
- Cerebrovascular insufficiency
- Cough
- Diabetes mellitus
- Hypercalcemia
- Hypercholesterolemia
- Hyperparathyroidism
- Immunosuppression
- Kidney disease with reduction in GFR
- Neutropenic disorder
- Recipient of organ transplant
- Renal artery stenosis
- Squamous cell carcinoma of skin
- Sympathectomy
- Systemic lupus erythematosus
CAPTOPRIL-HYDROCHLOROTHIAZIDE (CAPTOPRIL/HYDROCHLOROTHIAZIDE)
- Hypertension
- Hypochloremic alkalosis
- Hypokalemia
- Hyponatremia
- Hypotension
- Cough
More Frequent
Severe
Less Severe
- Angina
- Arthralgias
- Fever
- Hyperglycemia
- Hyperkalemia
- Hypomagnesemia
- Hypotension
- Kidney disease with reduction in GFR
- Skin rash
- Abdominal pain with cramps
- Abnormal sexual function
- Anorexia
- Diarrhea
- Dizziness
- Dysgeusia
- Eosinophilia
- Fatigue
- Nausea
- Orthostatic hypotension
- Pruritus of skin
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute myocardial infarction
- Acute pancreatitis
- Acute renal failure
- Agranulocytosis
- Anaphylaxis
- Anemia
- Angioedema
- Aplastic anemia
- Bronchospastic pulmonary disease
- Chest pain
- Cholestasis
- Chronic heart failure
- Eosinophilic pneumonia
- Erythema multiforme
- Exfoliative dermatitis
- Flushing
- Gout
- Head and neck angioedema
- Hemolytic anemia
- Hepatic necrosis
- Hepatitis
- Hypercalcemia
- Hyperparathyroidism
- Hypersensitivity angiitis
- Hyperuricemia
- Hyponatremia
- Interstitial nephritis
- Interstitial pneumonitis
- Intestinal angioedema
- Jaundice
- Leukopenia
- Myopia
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Pancytopenia
- Pemphigus
- Proteinuria
- Purpura
- Raynaud's phenomenon
- Secondary angle-closure glaucoma
- Squamous cell carcinoma of skin
- Stevens-johnson syndrome
- Systemic lupus erythematosus
- Tachycardia
- Thrombocytopenic disorder
- Toxic epidermal necrolysis
- Vasculitis
Less Severe
- Acute confusion
- Ataxia
- Basal cell carcinoma of skin
- Blurred vision
- Constipation
- Depression
- Drowsy
- Dyspepsia
- Erectile dysfunction
- Fever
- Gastrointestinal irritation
- General weakness
- Glossitis
- Gynecomastia
- Headache disorder
- Hypercholesterolemia
- Hypertriglyceridemia
- Muscle spasm
- Muscle weakness
- Myalgias
- Nervousness
- Palpitations
- Paresthesia
- Sialoadenitis
- Skin rash
- Urticaria
- Vertigo
- Xanthopsia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Captopril
Monitor for excessive and prolonged decrease in blood pressure, urine output, especially neonates. Reports of prolonged hypotension, oliguria and seizures. No established safety and efficacy.
- 1 Day – 364 Days
- Monitor for excessive and prolonged decrease in blood pressure, urine output, especially neonates. Reports of prolonged hypotension, oliguria and seizures. No established safety and efficacy.
Captopril
- Severity Level:
1
- Additional Notes: Fetal death/morbidity w/use in 2nd & 3rd trimester, stop when pregnancy detected
Hydrochlorothiazide
- Severity Level:
B
- Additional Notes: Not recommended in pre-eclampsia and other pregnancy-induced hypertension.
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Captopril
Limited data suggest amt excreted minimal, no adverse effects in infant
Limited amounts excreted with no known adverse effects in infant.
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data suggest amt excreted minimal, no adverse effects in infant |
Hydrochlorothiazide
Limited data suggest amt excreted minimal, no adverse effects in infant
Limited amounts excreted with no known adverse effects in infant.
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited amounts excreted with no known adverse effects in infant. |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Captopril
Cardiovascular-Monitor for hypotension more closely in the elderly. Metabolic-Monitor for hyperkalemia which has a higher incidence in the elderly. Renal-Increased risk for neutropenia in patients with renal impairment.
Cardiovascular-Increased sensitivity to effects on blood pressure. Metabolic-More likely to develop hypokalemia, hypomagnesemia, or hyponatremia. Endocrine-May exacerbate SIADH. May worsen glucose control in patients with diabetes. Renal-Not effective with CrCL < 30mL/min.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | N | N | N |
BEERS: N HEDIS: N STOPP: Y
Hydrochlorothiazide
Cardiovascular-Monitor for hypotension more closely in the elderly. Metabolic-Monitor for hyperkalemia which has a higher incidence in the elderly. Renal-Increased risk for neutropenia in patients with renal impairment.
Cardiovascular-Increased sensitivity to effects on blood pressure. Metabolic-More likely to develop hypokalemia, hypomagnesemia, or hyponatremia. Endocrine-May exacerbate SIADH. May worsen glucose control in patients with diabetes. Renal-Not effective with CrCL < 30mL/min.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | N | N | Y |
BEERS: Y HEDIS: N STOPP: Y
No Known Risk
None
- This drug can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy. Therefore, it is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control while taking this medication. If you are planning pregnancy, become pregnant, or think you may be pregnant, contact your doctor right away.
| Hypertension | |
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
| 0-9 | A-Z |
|---|---|
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
Formulary Reference Tool