SYMTUZA (darunavir eth/cobicistat/emtricitabine/tenofovir alafenamide)
- HIV infection
800 mg-150 mg-200 mg-10 mg tablet
- 1 tablet by oral route once daily
HIV infection
- 1 tablet by oral route once daily
- adefovir
- Advicor
- alfuzosin
- Altoprev
- apixaban
- avanafil
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- Brilinta
- bromocriptine
- cabergoline
- Cafergot
- calcium-mag-B complex-D3-hrb61
- Camptosar
- carbamazepine
- Carbatrol
- Cerebyx
- cidofovir
- Cold & Flu Fighter
- conivaptan in 5 % dextrose
- Cycloset
- D.h.e.45
- Detrol La
- dihydroergotamine
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Donnatal
- dronedarone
- dutasteride-tamsulosin
- eletriptan HBr
- Eliquis
- elvitegr-cobicist-emtric-tenof
- enzalutamide
- Epitol
- eplerenone
- Equetro
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- ezetimibe-simvastatin
- Fatigue Relief Complex
- Flomax
- fosphenytoin
- Hepsera
- Inspra
- irinotecan
- isoniazid-rifamp-pyrazinamide
- Jalyn
- Juxtapid
- Kombiglyze Xr
- Latuda
- Levitra
- lomitapide
- lovastatin
- Luminal
- lurasidone
- methylergonovine
- Mevacor
- midazolam
- Migergot
- Migranal
- Multaq
- Mysoline
- nevirapine
- niacin-lovastatin
- niacin-simvastatin
- Orap
- Parlodel
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- pimozide
- primidone
- Rapaflo
- Relpax
- Revatio
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- rivaroxaban
- Samsca
- saxagliptin-metformin
- sildenafil
- silodosin
- Simcor
- simvastatin
- St. John's wort
- Stendra
- Stribild
- tamsulosin
- Tegretol
- Tegretol Xr
- ticagrelor
- tolterodine
- tolvaptan
- triazolam
- Uroxatral
- Vaprisol
- vardenafil
- Viramune
- Viramune Xr
- Vistide
- vit C-St. John wort-elder-hb30
- Vytorin 10-10
- Vytorin 10-20
- Vytorin 10-40
- Vytorin 10-80
- Women's Complex
- Xarelto
- Xtandi
- Zocor
Contraindicated
- A-methapred
- Abstral
- Actiq
- Advair Diskus
- Advair Hfa
- Afinitor
- Afinitor Disperz
- Alfenta
- alfentanil
- Altavera (28)
- Alyacen 1/35 (28)
- Alyacen 7/7/7 (28)
- Amethia
- Amethia Lo
- Amethyst
- Apri
- Aranelle (28)
- Aristospan Intra-articular
- Aristospan Intralesional
- Astagraf Xl
- Aubra
- Aviane
- azelastine-fluticasone
- Azurette (28)
- B6-FA-B12-co Q10-herb no.225
- Balziva (28)
- Beauty & Skin Therapy
- Beyaz
- bosentan
- Breo Ellipta
- Brevicon (28)
- Briellyn
- budesonide
- budesonide-formoterol
- Camila
- Camrese
- Camrese Lo
- Caziant (28)
- Chateal
- colchicine
- colchicine-probenecid
- Colcrys
- Cryselle (28)
- Cyclafem 1/35 (28)
- Cyclafem 7/7/7 (28)
- Cyclessa (28)
- cyclosporine
- cyclosporine modified
- Dasetta 1/35 (28)
- Dasetta 7/7/7 (28)
- Daysee
- Depo-medrol
- Depo-provera
- Depo-subq Provera 104
- desog-e.estradiol/e.estradiol
- Desogen
- desogestrel-ethinyl estradiol
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- drospirenone-e.estradiol-lm.FA
- drospirenone-ethinyl estradiol
- Duragesic
- Dymista
- Elinest
- Emoquette
- Endocet
- Endodan
- Enpresse
- Enskyce
- Entocort Ec
- Errin
- Estarylla
- estradiol valerate-dienogest
- Estrostep Fe-28
- ethynodiol diac-eth estradiol
- etonogestrel
- etonogestrel-ethinyl estradiol
- everolimus
- Ez Use Joint-tunnel-trigger
- Falmina (28)
- Femcon Fe
- fentanyl
- fentanyl citrate
- fentanyl citrate (PF)
- Fentora
- Flo-pred
- Flonase
- Flovent Diskus
- Flovent Hfa
- fluticasone
- fluticasone furoate
- fluticasone-salmeterol
- fluticasone-vilanterol
- Fortavit
- Generess Fe
- Gengraf
- Gianvi (28)
- Gildagia
- Gildess
- Gildess Fe
- guanfacine
- Healthy Heart Complex
- Heather
- Hecoria
- Hycamtin
- ibuprofen-oxycodone
- Incivek
- Introvale
- Intuniv Er
- Invirase
- Jencycla
- Jolessa
- Jolivette
- Junel 1.5/30 (21)
- Junel 1/20 (21)
- Junel Fe 1.5/30 (28)
- Junel Fe 1/20 (28)
- Kaletra
- Kariva (28)
- Kelnor 1/35 (28)
- Kenalog
- Korlym
- Kurvelo
- L norgest&E estradiol-E estrad
- Larin 1/20 (21)
- Larin Fe
- Lazanda
- Leena 28
- Lessina
- Levonest (28)
- levonorg-eth estrad triphasic
- levonorgestrel
- levonorgestrel-ethinyl estrad
- Levora 0.15/30 (28)
- Levora-28
- Lo Loestrin Fe
- Loestrin 1.5/30 (21)
- Loestrin 1/20 (21)
- Loestrin Fe 1.5/30 (28)
- Loestrin Fe 1/20 (28)
- Lomedia 24 Fe
- lopinavir-ritonavir
- Loryna (28)
- Loseasonique
- Low-ogestrel (28)
- Lutera (28)
- Lyza
- macitentan
- Marlissa
- Maximum Daily Green
- Medrol
- Medrol (pak)
- medroxyprogesterone
- Megavite
- Megavite Golden Years 55+
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- Microgestin 1.5/30 (21)
- Microgestin 1/20 (21)
- Microgestin Fe 1.5/30 (28)
- Microgestin Fe 1/20 (28)
- mifepristone
- Millipred
- Millipred Dp
- Minastrin 24 Fe
- Mircette (28)
- Mirena
- Modicon (28)
- Mono-linyah
- Mononessa (28)
- MSM-collag-co Q10-herb no.226
- multivit-Fe-min-DNA-RNA-dsup4
- mv-iron-FA-Ca-beepoln-hb 101
- mv-mn-FA-herbs190&215-digest#4
- mv-mn-FA-lycopene-lut-#178herb
- mv-mn-iron-FA-herbal cmplx#190
- My Way
- Mycobutin
- Myzilra
- Nasacort
- Nasacort Aq
- Natazia
- Necon 0.5/35 (28)
- Necon 1/35 (28)
- Necon 1/50 (28)
- Necon 10/11 (28)
- Necon 7/7/7 (28)
- Neoral
- Nexplanon
- Next Choice One Dose
- Nor-qd
- Nora-be
- norelgestrom-ethinyl estradiol
- noreth-ethinyl estradiol-iron
- norethin-e.estradiol triphasic
- norethin-eth estrad biphasic
- norethindrone (contraceptive)
- norethindrone ac-eth estradiol
- norethindrone-e.estradiol-iron
- norethindrone-ethin estradiol
- norethindrone-mestranol
- norgestimate-ethinyl estradiol
- norgestrel-ethinyl estradiol
- Norinyl 1+35 (28)
- Norinyl 1+50 (28)
- Nortrel 0.5/35 (28)
- Nortrel 1/35 (21)
- Nortrel 1/35 (28)
- Nortrel 7/7/7 (28)
- Nuvaring
- Ocella
- Ogestrel (28)
- Oleptro Er
- Olysio
- Opsumit
- Orapred
- Orapred Odt
- Orsythia
- Ortho Evra
- Ortho Micronor
- Ortho Tri-cyclen (28)
- Ortho Tri-cyclen Lo (28)
- Ortho-cept (28)
- Ortho-cyclen (28)
- Ortho-novum 1/35 (28)
- Ortho-novum 7/7/7 (28)
- Ovcon-35 (28)
- Oxecta
- oxycodone
- oxycodone-acetaminophen
- oxycodone-aspirin
- Oxycontin
- Pediapred
- Percocet
- Percodan
- Philith
- Physicians Ez Use M-pred
- Pimtrea (28)
- Pirmella
- Plan B One-step
- policosan-inositol niac-garlic
- Policosanol-garlic-niacin
- Portia
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- Previfem
- Priftin
- Primlev
- Prograf
- Pulmicort
- Pulmicort Flexhaler
- Quartette
- Quasense
- Rapamune
- Rayos
- Reclipsen (28)
- Rhinocort Aqua
- rifabutin
- rifapentine
- Roxicet
- Safyral
- salmeterol
- Sandimmune
- saquinavir mesylate
- Seasonique
- Serevent Diskus
- simeprevir
- sirolimus
- Skyla
- Solu-medrol
- Solu-medrol (pf)
- Sprintec (28)
- Sronyx
- Sublimaze (pf)
- Subsys
- Syeda
- Symbicort
- tacrolimus
- telaprevir
- temsirolimus
- Tenex
- Tilia Fe
- topotecan
- Torisel
- Tracleer
- trazodone
- Tri-estarylla
- Tri-legest Fe
- Tri-linyah
- Tri-norinyl (28)
- Tri-previfem (28)
- Tri-sprintec (28)
- triamcinolone acetonide
- triamcinolone hexacetonide
- triamcinolone-lidocaine
- Trinessa (28)
- Trivora (28)
- Uceris
- Velivet Triphasic Regimen (28)
- Veramyst
- Veripred 20
- Vestura (28)
- Vfend
- Vfend Iv
- Viorele (28)
- voriconazole
- Vyfemla (28)
- Wera (28)
- Wymzya Fe
- Xartemis Xr
- Yasmin (28)
- Yaz 28
- Zarah
- Zenchent (28)
- Zenchent Fe
- Zeosa
- Zortress
- Zovia 1/35E (28)
- Zovia 1/50E (28)
Severe
Moderate
- Abilify
- Abilify Discmelt
- Abilify Maintena
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- afatinib
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- Ambien
- Ambien Cr
- amiodarone
- amiodarone in dextrose,iso-osm
- amlodipine-atorvastatin
- amoxicil-clarithromy-lansopraz
- Anaprox
- Anaprox Ds
- Ansaid
- Anti-diarrhea
- Anti-diarrheal (lope)-anti-gas
- Anti-diarrheal (loperamide)
- aripiprazole
- artemether-lumefantrine
- Arthrotec 50
- atorvastatin
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- buspirone
- Caduet
- Caldolor
- Cambia
- Cataflam
- Celebrex
- celecoxib
- Child Ibuprofen
- Children's Advil
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- cilostazol
- clarithromycin
- Coartem
- Cold & Sinus Pain Relief
- Cold-sinus Relief
- Cordarone
- darifenacin
- Daypro
- Detrol
- dextromethorphan-quinidine
- Diamode
- diclofenac epolamine
- diclofenac potassium
- diclofenac sodium
- diclofenac submicronized
- diclofenac-misoprostol
- didanosine
- Duexis
- Ec-naprosyn
- Edluar
- Enablex
- eszopiclone
- etodolac
- ezetimibe-atorvastatin
- Feldene
- fenoprofen
- fesoterodine
- Fetzima
- Flanax
- Flector
- flurbiprofen
- Gilotrif
- hydrocodone-ibuprofen
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-phenylephrine HCl
- Imodium Multi-symptom Relief
- Indocin
- indomethacin
- indomethacin sodium
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- Intermezzo
- Istodax
- itraconazole
- ivacaftor
- Kalydeco
- ketoconazole
- ketoprofen
- ketorolac
- levomilnacipran
- lidocaine (PF)
- lidocaine in D5W (PF)
- Lipitor
- Liptruzet
- Lo-peramide
- loperamide
- loperamide-simethicone
- Lunesta
- Medi-profen
- Mediproxen
- mefenamic acid
- mefloquine
- meloxicam
- Midol (naproxen)
- Mobic
- Motrin Ib
- Motrin Pm
- nabumetone
- Nalfon
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- Neoprofen (ibuprofen Lysn)(pf)
- Nexterone
- Nuedexta
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Onglyza
- Onmel
- oxaprozin
- Pacerone
- Pennsaid
- piroxicam
- Pletal
- pomalidomide
- Pomalyst
- Ponstel
- Pravachol
- pravastatin
- Prevpac
- Provil
- pseudoephedrine-ibuprofen
- quinidine gluconate
- quinidine sulfate
- regorafenib
- Reprexain
- romidepsin
- saxagliptin
- Sinus & Cold-d
- Solaraze
- solifenacin
- Sporanox
- Sporanox Pulsepak
- Sprix
- Stivarga
- sulindac
- tolmetin
- Toviaz
- Ultra A-d
- Vesicare
- Viagra
- Vicoprofen
- Videx 2 Gram Pediatric
- Videx 4 Gram Pediatric
- Videx Ec
- Vimovo
- Voltaren-xr
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- Xylocaine (cardiac) (pf)
- Zipsor
- zolpidem
- Zolpimist
- Zorvolex
- Lactating mother
- Lactic acidosis
- Pregnancy
Contraindicated
- Acute renal failure
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Disease of liver
- Fanconi syndrome
- Hypophosphatemia
- Kidney disease with reduction in GFR
- Osteomalacia
- Pathological fracture
Severe
Moderate
- Chronic hepatitis B
- Diabetes mellitus
- Hemophilia
- Hypercholesterolemia
- Hypertriglyceridemia
- Kidney disease with likely reduction in GFR
- Osteopenia
SYMTUZA (darunavir eth/cobicistat/emtricitabine/tenofovir alafenamide)
- HIV infection
- Depression
- Gastroenteritis
- Hyperbilirubinemia
- Jaundice
- Scleral icterus
- Skin rash
- Vomiting
- Acute abdominal pain
- Back pain
- Cough
- Diarrhea
- Dizziness
- Dream disorder
- Fatigue
- Fever
- Flatulence
- General weakness
- Headache disorder
- Hyperlipidemia
- Insomnia
- Nausea
- Pain
- Pruritus of skin
- Rhinitis
- Skin rash
- Vomiting
More Frequent
Severe
Less Severe
- Abdominal distension
- Anemia
- Bullous dermatitis
- Hypercholesterolemia
- Increased alanine transaminase
- Increased aspartate transaminase
- Maculopapular rash
- Peripheral neuropathy
- Pneumonia
- Urticaria
- Acute bacterial otitis media
- Anorexia
- Arthralgias
- Chest pain
- Depression
- Diarrhea
- Dream disorder
- Dyspepsia
- Fatigue
- Flatulence
- Headache disorder
- Hypercholesterolemia
- Hypertriglyceridemia
- Insomnia
- Myalgias
- Paresthesia
- Pharyngitis
- Polyuria
- Proteinuria
- Pruritus of skin
- Sinusitis
- Urticaria
- Vomiting
- Weight loss
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute generalized exanthematous pustulosis
- Acute pancreatitis
- Acute renal failure
- Allergic dermatitis
- Angioedema
- Autoimmune hepatitis
- Avascular necrosis of bone
- DRESS syndrome
- Dyspnea
- Eosinophilia
- Erythema multiforme
- Fanconi syndrome
- Graves' disease
- Guillain-barre syndrome
- Hepatic failure
- Hepatitis
- Hypersensitivity drug reaction
- Hypokalemia
- Hypophosphatemia
- Interstitial nephritis
- Kidney disease with reduction in GFR
- Kidney stone
- Lactic acidosis
- Maculopapular rash
- Nephrogenic diabetes insipidus
- Osteomalacia
- Pancreatitis
- Peripheral neuropathy
- Pneumonia
- Polymyositis
- Renal tubular necrosis
- Rhabdomyolysis
- Steatosis of liver
- Stevens-johnson syndrome
- Toxic epidermal necrolysis
Less Severe
- Arthralgias
- Diabetes mellitus
- Dream disorder
- Dyschromia
- Fever
- General weakness
- Hypercholesterolemia
- Hyperglycemia
- Hyperhidrosis
- Hypertriglyceridemia
- Lipodystrophy associated with HIV
- Muscle weakness
- Myalgias
- Myopathy
- Skin inflammation
- Upper abdominal pain
- Urticaria
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Emtricit_Tenofovir alafen_cob_daru
No safety and efficacy weight < 40 kg or age < 12 years.
- 1 Day – 12 Years
- No safety and efficacy weight < 40 kg or age < 12 years.
Cobicistat
- Severity Level:
1
- Additional Notes: Maternal exposure levels are substantially low and may affect treatment efficacy
Darunavir
- Severity Level:
2
- Additional Notes: Epidemiological studies/ post-market data suggest no increased risk of birth def
Emtricitabine
- Severity Level:
2
- Additional Notes: Available human data show no increased risk for major malformations.
Tenofovir Alafenamide
- Severity Level:
2
- Additional Notes: Insuff human data; animal data do not sug dev tox
Contraindicated
Cobicistat
Cdc does not recommend breastfeeding in hiv-positive women
Cdc does not recommend breastfeeding in hiv-positive women.
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Cdc does not recommend breastfeeding in hiv-positive women |
Darunavir
Cdc does not recommend breastfeeding in hiv-positive women
Cdc does not recommend breastfeeding in hiv-positive women.
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Cdc does not recommend breastfeeding in hiv-positive women. |
Emtricitabine
Cdc does not recommend breastfeeding in hiv-positive women
Cdc does not recommend breastfeeding in hiv-positive women.
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Excreted | Not known; no or inclusive data | Cdc does not recommend breastfeeding in hiv-positive women. |
Precaution Exists
Tenofovir
Limited data suggest no known adverse effects in nursing infant
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data suggest no known adverse effects in nursing infant |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Emtricitabine
Renal- Adhere to manufacturer guidelines for renal impairment and lower CrCL.
Musculoskeletal-Decreases in bone mineral density have been observed. Consider calcium and vitamin D3 supplementation.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | Y | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
Tenofovir Alafenamide
Renal- Adhere to manufacturer guidelines for renal impairment and lower CrCL.
Musculoskeletal-Decreases in bone mineral density have been observed. Consider calcium and vitamin D3 supplementation.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | Y | Y | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- If you have hepatitis B infection, your hepatitis symptoms may get worse or become very serious if you stop taking this medication. Talk with your doctor before stopping this medication. Your doctor will monitor liver tests for several months after you stop darunavir/cobicistat/emtricitabine/tenofovir alafenamide. Tell your doctor right away if you have symptoms of worsening liver problems.
HIV infection | |
B20 | Human immunodeficiency virus [HIv] disease |
B97.35 | Human immunodeficiency virus, type 2 [HIV 2] as the cause of diseases classified elsewhere |
O98.7 | Human immunodeficiency virus [HIv] disease complicating pregnancy, childbirth and the puerperium |
O98.71 | Human immunodeficiency virus [HIv] disease complicating pregnancy |
O98.711 | Human immunodeficiency virus [HIv] disease complicating pregnancy, first trimester |
O98.712 | Human immunodeficiency virus [HIv] disease complicating pregnancy, second trimester |
O98.713 | Human immunodeficiency virus [HIv] disease complicating pregnancy, third trimester |
O98.719 | Human immunodeficiency virus [HIv] disease complicating pregnancy, unspecified trimester |
O98.72 | Human immunodeficiency virus [HIv] disease complicating childbirth |
O98.73 | Human immunodeficiency virus [HIv] disease complicating the puerperium |
Z21 | Asymptomatic human immunodeficiency virus [HIv] infection status |
0-9 | A-Z |
---|---|
B20 | Human immunodeficiency virus [HIv] disease |
B97.35 | Human immunodeficiency virus, type 2 [HIV 2] as the cause of diseases classified elsewhere |
O98.7 | Human immunodeficiency virus [HIv] disease complicating pregnancy, childbirth and the puerperium |
O98.71 | Human immunodeficiency virus [HIv] disease complicating pregnancy |
O98.711 | Human immunodeficiency virus [HIv] disease complicating pregnancy, first trimester |
O98.712 | Human immunodeficiency virus [HIv] disease complicating pregnancy, second trimester |
O98.713 | Human immunodeficiency virus [HIv] disease complicating pregnancy, third trimester |
O98.719 | Human immunodeficiency virus [HIv] disease complicating pregnancy, unspecified trimester |
O98.72 | Human immunodeficiency virus [HIv] disease complicating childbirth |
O98.73 | Human immunodeficiency virus [HIv] disease complicating the puerperium |
Z21 | Asymptomatic human immunodeficiency virus [HIv] infection status |