ERLEADA (apalutamide)

Moderate

• A-hydrocort

• A-methapred

• Abilify

• Abilify Discmelt

• Abilify Maintena

• Ablavar

• Adoxa

• afatinib

• alfuzosin

• alprazolam

• Alprazolam Intensol

• amoxicil-clarithromy-lansopraz

• Anucort-hc

• Anusol-hc

• Anzemet

• Apokyn

• apomorphine

• aripiprazole

• Aristospan Intra-articular

• Aristospan Intralesional

• Aromasin

• arsenic trioxide

• Astramorph-pf

• Ativan

• Avelox

• Avelox Abc Pack

• Avelox In Nacl (iso-osmotic)

• Avidoxy

• Avinza

• betamethasone acet & sod phos

• Betapace

• Betapace Af

• Biaxin

• Biaxin Xl

• Biaxin Xl Pak

• bosentan

• budesonide

• Buprenex

• buprenorphine

• buprenorphine-naloxone

• Butrans

• Celestone Soluspan

• Celexa

• Cipro

• Cipro In D5W

• Cipro Xr

• ciprofloxacin

• ciprofloxacin (mixture)

• ciprofloxacin in D5W

• citalopram

• clarithromycin

• clozapine

• Clozaril

• Colocort

• Cortef

• Cortenema

• Cortifoam

• cortisone

• Daliresp

• Depo-medrol

• Depodur (pf)

• dexamethasone

• Dexamethasone Intensol

• dexamethasone sodium phos (PF)

• dexamethasone sodium phosphate

• Dexpak 10 Day

• Dexpak 13 Day

• Dexpak 6 Day

• Diastat

• Diastat Acudial

• diazepam

• Diazepam Intensol

• Diskets

• dofetilide

• dolasetron

• Dolophine

• Doryx

• Doxy-100

• doxycycline calcium

• doxycycline hyclate

• doxycycline monohydrate

• Duramorph (pf)

• Entocort Ec

• eribulin

• Erythrocin

• erythromycin

• erythromycin-sulfisoxazole

• escitalopram oxalate

• exemestane

• Ez Use Joint-tunnel-trigger

• ezogabine

• Fazaclo

• fingolimod

• First-duke's

• First-mary's Mouthwash

• Flo-pred

• fludrocortisone

• gadofosveset trisodium

• Gilenya

• Gilotrif

• Grx Hicort 25

• Halaven

• Haldol

• Haldol Decanoate

• haloperidol

• haloperidol decanoate

• haloperidol lactate

• Hemril-30

• hydrocortisone

• hydrocortisone acetate

• hydrocortisone sod succ (PF)

• hydrocortisone sod succinate

• Iclusig

• Invirase

• Kadian

• Kaletra

• Kenalog

• Ketek

• Levaquin

• Levaquin In 5 % Dextrose

• levofloxacin

• levofloxacin in D5W

• Lexapro

• lopinavir-ritonavir

• lorazepam

• Lorazepam Intensol

• macitentan

• Medrol

• Medrol (pak)

• methadone

• Methadone Intensol

• Methadose

• methylprednisolone

• methylprednisolone acetate

• methylprednisolone sod suc(PF)

• methylprednisolone sodium succ

• methylprednisolone-bupivacaine

• midazolam

• midazolam (PF)

• Millipred

• Millipred Dp

• Monodox

• Morgidox

• morphine

• morphine (PF)

• morphine concentrate

• morphine liposomal (PF)

• moxifloxacin

• moxifloxacin in NaCl (iso-osm)

• Ms Contin

• Niravam

• norfloxacin

• Noroxin

• Noxafil

• nystatin-hydrocortisone-diphen

• nystatin-TCN-HC-diphenhydramin

• Omeclamox-pak

• omeprazole-clarith-amoxicillin

• ondansetron

• ondansetron HCl

• ondansetron HCl (PF)

• Opsumit

• Oracea

• Orapred

• Orapred Odt

• ospemifene

• Osphena

• pasireotide

• Pediapred

• Physicians Ez Use M-pred

• ponatinib

• posaconazole

• Potiga

• prednisolone

• prednisolone acetate

• prednisolone sodium phosphate

• prednisone

• Prednisone Intensol

• Prevpac

• Proctocort

• propafenone

• Rayos

• Rectacort-hc

• regorafenib

• Risperdal

• Risperdal Consta

• Risperdal M-tab

• risperidone

• risperidone microspheres

• roflumilast

• Rythmol

• saquinavir mesylate

• Seroquel

• Signifor

• Solu-cortef

• Solu-cortef (pf)

• Solu-medrol

• Solu-medrol (pf)

• Sorine

• sotalol

• Sotalol Af

• Stivarga

• Suboxone

• telavancin

• telithromycin

• tetrabenazine

• Tikosyn

• Tracleer

• triamcinolone acetonide

• triamcinolone hexacetonide

• triamcinolone-lidocaine

• triazolam

• Trisenox

• Uceris

• Uroxatral

• Valium

• Veripred 20

• Versacloz

• Vibativ

• Vibramycin

• Xanax

• Xanax Xr

• Xenazine

• Zofran

• Zofran Odt

• Zubsolv

• Zuplenz

Moderate

• None

Apalutamide

• Severity Level:

  1

• Additional Notes: Based on drug pharmacology developmental toxicity is possible.

Contraindicated

None

General	Excretion Potential	Effect on Infant	Notes
			None

Precaution Exists

Apalutamide

Not indicated in females, insufficient data available

General	Excretion Potential	Effect on Infant	Notes
Evaluate use carefully	Unknown	Not known; no or inclusive data	Not indicated in females, insufficient data available

No Known Risk

None

General	Excretion Potential	Effect on Infant	Notes
			None

Contraindicated

None

Precaution Exists

Apalutamide

General-Greater risk of grade 3-4 reactions in patients >75 years or older Endocrine-Risk of bone fractures. Falls occurred with increased frequency in elderly (8-19%). Evaluate for fall risk.

Organ / System	HEP	REN	CARD	ENDO	NEURO / PSYCH	PULM
Increased Risk / Adverse Effects	N	N	N	N	N	Y

BEERS: N     HEDIS: N     STOPP: N

No Known Risk

None

0-9	A-Z
C61	Malignant neoplasm of prostate
C61	Malignant neoplasm of prostate
Z19.1	Hormone sensitive malignancy status