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CINVANTI (APREPITANT)
- Prevention of chemotherapy-induced nausea and vomiting
7.2 mg/mL intravenous emulsion
- Dosage information is not available
Prevention of chemotherapy-induced nausea and vomiting
- Infuse 130 mg over 30 minute(s) by intravenous route once on day 1 approximately 30 minutes before chemotherapy
- Infuse 100 mg over 30 minute(s) by intravenous route once on day 1 approximately 30 minutes before chemotherapy
- Juxtapid
- lomitapide
- Orap
- pimozide
Contraindicated
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Bosulif
- bosutinib
- calcium-mag-B complex-D3-hrb61
- carbamazepine
- Carbatrol
- Cerebyx
- clozapine
- Clozaril
- colchicine
- colchicine-probenecid
- Colcrys
- Cold & Flu Fighter
- Coumadin
- deferiprone
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- enzalutamide
- Epitol
- Equetro
- Fatigue Relief Complex
- Fazaclo
- Ferriprox
- fosphenytoin
- guanfacine
- ibrutinib
- Imbruvica
- Intuniv Er
- isoniazid-rifamp-pyrazinamide
- Jantoven
- Olysio
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Samsca
- simeprevir
- St. John's wort
- Tegretol
- Tegretol Xr
- Tenex
- tolvaptan
- Versacloz
- vit C-St. John wort-elder-hb30
- warfarin
- Women's Complex
- Xtandi
Severe
Moderate
- A-methapred
- Abstral
- Actiq
- Afinitor
- Afinitor Disperz
- Alfenta
- alfentanil
- alprazolam
- Alprazolam Intensol
- Altavera (28)
- Alyacen 1/35 (28)
- Alyacen 7/7/7 (28)
- Amethia
- Amethia Lo
- Amethyst
- Apri
- Aranelle (28)
- Aubra
- avanafil
- Aviane
- Azurette (28)
- Balziva (28)
- Beyaz
- bosentan
- Brevicon (28)
- Briellyn
- Camila
- Camrese
- Camrese Lo
- Caziant (28)
- Chateal
- cilostazol
- Cryselle (28)
- Cyclafem 1/35 (28)
- Cyclafem 7/7/7 (28)
- Cyclessa (28)
- Dasetta 1/35 (28)
- Dasetta 7/7/7 (28)
- Daysee
- Depo-medrol
- Depo-provera
- Depo-subq Provera 104
- desog-e.estradiol/e.estradiol
- Desogen
- desogestrel-ethinyl estradiol
- dexamethasone
- Dexamethasone Intensol
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- drospirenone-e.estradiol-lm.FA
- drospirenone-ethinyl estradiol
- Duragesic
- Elinest
- Emoquette
- Endocet
- Endodan
- Enpresse
- Enskyce
- eplerenone
- Errin
- Estarylla
- estradiol valerate-dienogest
- Estrostep Fe-28
- ethynodiol diac-eth estradiol
- etonogestrel
- etonogestrel-ethinyl estradiol
- everolimus
- Falmina (28)
- Femcon Fe
- fentanyl
- fentanyl citrate
- fentanyl citrate (PF)
- Fentora
- Generess Fe
- Gianvi (28)
- Gildagia
- Gildess
- Gildess Fe
- Heather
- ibuprofen-oxycodone
- Inspra
- Introvale
- ivacaftor
- Jencycla
- Jolessa
- Jolivette
- Junel 1.5/30 (21)
- Junel 1/20 (21)
- Junel Fe 1.5/30 (28)
- Junel Fe 1/20 (28)
- Kalydeco
- Kariva (28)
- Kelnor 1/35 (28)
- Kurvelo
- L norgest&E estradiol-E estrad
- Larin 1/20 (21)
- Larin Fe
- Latuda
- Lazanda
- Leena 28
- Lessina
- Levitra
- Levonest (28)
- levonorg-eth estrad triphasic
- levonorgestrel
- levonorgestrel-ethinyl estrad
- Levora 0.15/30 (28)
- Levora-28
- Lo Loestrin Fe
- Loestrin 1.5/30 (21)
- Loestrin 1/20 (21)
- Loestrin Fe 1.5/30 (28)
- Loestrin Fe 1/20 (28)
- Lomedia 24 Fe
- Loryna (28)
- Loseasonique
- Low-ogestrel (28)
- lurasidone
- Lutera (28)
- Lyza
- Marlissa
- Medrol
- Medrol (pak)
- medroxyprogesterone
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- Microgestin 1.5/30 (21)
- Microgestin 1/20 (21)
- Microgestin Fe 1.5/30 (28)
- Microgestin Fe 1/20 (28)
- midazolam
- Minastrin 24 Fe
- Mircette (28)
- Mirena
- Modicon (28)
- Mono-linyah
- Mononessa (28)
- My Way
- Myzilra
- Natazia
- Necon 0.5/35 (28)
- Necon 1/35 (28)
- Necon 1/50 (28)
- Necon 10/11 (28)
- Necon 7/7/7 (28)
- Nexplanon
- Next Choice One Dose
- Niravam
- Nor-qd
- Nora-be
- norelgestrom-ethinyl estradiol
- noreth-ethinyl estradiol-iron
- norethin-e.estradiol triphasic
- norethin-eth estrad biphasic
- norethindrone (contraceptive)
- norethindrone ac-eth estradiol
- norethindrone-e.estradiol-iron
- norethindrone-ethin estradiol
- norethindrone-mestranol
- norgestimate-ethinyl estradiol
- norgestrel-ethinyl estradiol
- Norinyl 1+35 (28)
- Norinyl 1+50 (28)
- Nortrel 0.5/35 (28)
- Nortrel 1/35 (21)
- Nortrel 1/35 (28)
- Nortrel 7/7/7 (28)
- Nuvaring
- Ocella
- Ogestrel (28)
- Orsythia
- Ortho Evra
- Ortho Micronor
- Ortho Tri-cyclen (28)
- Ortho Tri-cyclen Lo (28)
- Ortho-cept (28)
- Ortho-cyclen (28)
- Ortho-novum 1/35 (28)
- Ortho-novum 7/7/7 (28)
- Ovcon-35 (28)
- Oxecta
- oxycodone
- oxycodone-acetaminophen
- oxycodone-aspirin
- Oxycontin
- Percocet
- Percodan
- Philith
- Physicians Ez Use M-pred
- Pimtrea (28)
- Pirmella
- Plan B One-step
- Pletal
- Portia
- Previfem
- Primlev
- Quartette
- Quasense
- Reclipsen (28)
- Roxicet
- Safyral
- Seasonique
- Skyla
- Solu-medrol
- Solu-medrol (pf)
- Sprintec (28)
- Sronyx
- Stendra
- Sublimaze (pf)
- Subsys
- Syeda
- Tilia Fe
- Tracleer
- Tri-estarylla
- Tri-legest Fe
- Tri-linyah
- Tri-norinyl (28)
- Tri-previfem (28)
- Tri-sprintec (28)
- triazolam
- Trinessa (28)
- Trivora (28)
- vardenafil
- Velivet Triphasic Regimen (28)
- Vestura (28)
- Viorele (28)
- Vyfemla (28)
- Wera (28)
- Wymzya Fe
- Xanax
- Xanax Xr
- Xartemis Xr
- Yasmin (28)
- Yaz 28
- Zarah
- Zenchent (28)
- Zenchent Fe
- Zeosa
- Zortress
- Zovia 1/35E (28)
- Zovia 1/50E (28)
- None
Contraindicated
- Pregnancy
Severe
Moderate
- None
CINVANTI (APREPITANT)
- Prevention of chemotherapy-induced nausea and vomiting
- Dehydration
- Abdominal pain with cramps
- Constipation
- Diarrhea
- Dizziness
- Dyspepsia
- Eructation
- Fatigue
- General weakness
- Hiccups
- Hypotension
- Nausea
- Pruritus of skin
More Frequent
Severe
Less Severe
- Gastritis
- Increased alanine transaminase
- Leukopenia
- Neutropenic disorder
- Anorexia
- Fever
- Headache disorder
- Heartburn
- Insomnia
- Tinnitus
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute duodenal ulcer with perforation
- Acute myocardial infarction
- Anaphylaxis
- Anemia
- Angioedema
- Bacterial sepsis
- Bradycardia
- Deep venous thrombosis
- Diabetes mellitus
- Dyspnea
- Edema
- Hypertension
- Hypokalemia
- Interstitial pneumonitis
- Kidney disease with reduction in GFR
- Malignancy
- Muscle weakness
- Neutropenic colitis
- Pulmonary thromboembolism
- Respiratory depression
- Stevens-johnson syndrome
- Tachycardia
- Thrombocytopenic disorder
- Toxic epidermal necrolysis
- Urticaria
Less Severe
- Abnormal hepatic function tests
- Acneiform eruption
- Acute confusion
- Alopecia
- Arthralgias
- Back pain
- Chills
- Conjunctivitis
- Cough
- Depression
- Drug-induced hot flash
- Dysgeusia
- Dysphagia
- Dysuria
- Flatulence
- Flushing
- Gastroesophageal reflux disease
- Hyperhidrosis
- Hypesthesia
- Increased urinary frequency
- Malaise
- Myalgias
- Nasal congestion
- Palpitations
- Pelvic pain
- Periorbital edema
- Peripheral neuropathy
- Pharyngitis
- Polyuria
- Rhinorrhea
- Sialorrhea
- Skin photosensitivity
- Skin rash
- Sneezing
- Stomatitis
- Symptoms of anxiety
- Upper respiratory infection
- Voice change
- Weight loss
- Wheezing
- Xerostomia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Aprepitant (injection)
Safety and efficacy not established for injectable dose form.
- 1 Day – 18 Years
- Safety and efficacy not established for injectable dose form.
Aprepitant (iv)
- Severity Level:
D
- Additional Notes: Contains ethanol, consider maternal benefit versus fetal risk
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Aprepitant
Excreted in rat studies;Tumorigenic in rodent studies
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Excreted in rat studies;Tumorigenic in rodent studies |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
Formulary Reference Tool