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TRUVADA (EMTRICITABINE/TENOFOVIR DISOPROXIL FUMARATE)
- HIV infection
- HIV infection pre-exposure prophylaxis
100 mg-150 mg tablet
- Dosage information is not available
133 mg-200 mg tablet
- Dosage information is not available
167 mg-250 mg tablet
- Dosage information is not available
200 mg-300 mg tablet
- 1 tablet by oral route once daily
HIV infection
- 1 tablet by oral route once daily
HIV infection pre-exposure prophylaxis
- 1 tablet by oral route once daily
Prevention of HIV infection after exposure
- 1 tablet by oral route once daily
- adefovir
- cidofovir
- Hepsera
- Vistide
Contraindicated
- None
Severe
Moderate
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- Anaprox
- Anaprox Ds
- Ansaid
- Arthrotec 50
- atazanavir
- Caldolor
- Cambia
- Cataflam
- Celebrex
- celecoxib
- Child Ibuprofen
- Children's Advil
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- Cold & Sinus Pain Relief
- Cold-sinus Relief
- Daypro
- diclofenac epolamine
- diclofenac potassium
- diclofenac sodium
- diclofenac submicronized
- diclofenac-misoprostol
- didanosine
- Duexis
- Ec-naprosyn
- etodolac
- Feldene
- fenoprofen
- Flanax
- Flector
- flurbiprofen
- hydrocodone-ibuprofen
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-oxycodone
- ibuprofen-phenylephrine HCl
- Incivek
- Indocin
- indomethacin
- indomethacin sodium
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- ketoprofen
- ketorolac
- Medi-profen
- Mediproxen
- mefenamic acid
- meloxicam
- Midol (naproxen)
- Mobic
- Motrin Ib
- Motrin Pm
- nabumetone
- Nalfon
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- Neoprofen (ibuprofen Lysn)(pf)
- oxaprozin
- Pennsaid
- piroxicam
- Ponstel
- Provil
- pseudoephedrine-ibuprofen
- Reprexain
- Reyataz
- Sinus & Cold-d
- Solaraze
- Sprix
- sulindac
- telaprevir
- tolmetin
- Vicoprofen
- Videx 2 Gram Pediatric
- Videx 4 Gram Pediatric
- Videx Ec
- Vimovo
- Voltaren-xr
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- Zipsor
- Zorvolex
- Lactating mother
- Lactic acidosis
Contraindicated
- Acute renal failure
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Fanconi syndrome
- Hypophosphatemia
- Kidney disease with reduction in GFR
- Osteomalacia
- Pathological fracture
Severe
Moderate
- Chronic hepatitis B
- Kidney disease with likely reduction in GFR
- Osteopenia
TRUVADA (EMTRICITABINE/TENOFOVIR DISOPROXIL FUMARATE)
- HIV infection
- HIV infection pre-exposure prophylaxis
- None
- Depression
- Diarrhea
- Dizziness
- Dream disorder
- Fatigue
- Headache disorder
- Insomnia
- Lipodystrophy associated with HIV
- Nausea
- Skin rash
More Frequent
Severe
Less Severe
- Acute pancreatitis
- Dyspnea
- Fanconi syndrome
- Hypophosphatemia
- Kidney disease with reduction in GFR
- Acute abdominal pain
- Bullous dermatitis
- General weakness
- Maculopapular rash
- Pharyngitis
- Pruritus of skin
- Sinusitis
- Symptoms of anxiety
- Urticaria
- Vomiting
- Weight loss
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute renal failure
- Angioedema
- Drug-induced hepatitis
- Hypokalemia
- Lactic acidosis
- Osteomalacia
- Osteopenia
- Paresthesia
- Peripheral neuropathy
- Pneumonia
- Renal failure
- Renal tubular necrosis
- Rhabdomyolysis
- Steatosis of liver
Less Severe
- Arthralgias
- Back pain
- Cough
- Dyschromia
- Dyspepsia
- Fever
- Hyperhidrosis
- Muscle weakness
- Myalgias
- Myopathy
- Pain
- Rhinitis
Contraindicated
None
Severe Precaution
Emtricitabine_Tenofovir
Unknown effects on bone development with long term use. Safety and efficacy not established for weight < 17 kg.
- 1 Day – 3 Years
- Unknown effects on bone development with long term use. Safety and efficacy not established for weight < 17 kg.
Management or Monitoring Precaution
Emtricitabine_Tenofovir
Risk of lower bone density than expected for developing pediatric patients with tenofovir use. Assess BMD with history of fracture or bone loss. Fixed dose combination may be inappropriate and not indicated with weight < 17 kg.
- 3 Years – 18 Years
- Risk of lower bone density than expected for developing pediatric patients with tenofovir use. Assess BMD with history of fracture or bone loss. Fixed dose combination may be inappropriate and not indicated with weight < 17 kg.
Emtricitabine
- Severity Level:
2
- Additional Notes: Available human data show no increased risk for major malformations.
Tenofovir
- Severity Level:
2
- Additional Notes: Available human data show no increased risk for major birth defects
Contraindicated
Emtricitabine
Cdc does not recommend breastfeeding in hiv-positive women.
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Excreted | Not known; no or inclusive data | Cdc does not recommend breastfeeding in hiv-positive women. |
Precaution Exists
Tenofovir
Limited data suggest no known adverse effects in nursing infant
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data suggest no known adverse effects in nursing infant |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Emtricitabine
Renal- Adhere to manufacturer guidelines for renal impairment and lower CrCL.
Renal-Adjust dosing interval for CrCL<50mL/min. Fixed dose combinations containing tenofovir are not appropriate if dose adjustment is required. Musculoskeletal-Decreases in bone mineral density have been observed. Consider calcium and vitamin D3 supplementation.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
Tenofovir Disoproxil
Renal- Adhere to manufacturer guidelines for renal impairment and lower CrCL.
Renal-Adjust dosing interval for CrCL<50mL/min. Fixed dose combinations containing tenofovir are not appropriate if dose adjustment is required. Musculoskeletal-Decreases in bone mineral density have been observed. Consider calcium and vitamin D3 supplementation.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | Y | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- If you have hepatitis B infection as well as HIV, your hepatitis symptoms may get worse or become very serious if you stop taking this medication. Talk with your doctor before stopping this medication. Your doctor will perform liver function tests for several months after you stop.<br /><br /> If you are taking this product to prevent HIV infection, you must first get tested to be sure you are HIV-negative. Your doctor will perform laboratory tests before starting this medication and periodically during treatment (every 3 months) to make sure that you do not have HIV infection. Using this product will not always prevent HIV infection.<br /><br />To get the most benefit from it, take this product exactly as directed, and follow all prevention actions. (See also Uses section.) Tell your doctor right away if you have any signs of HIV infection (such as tiredness, fever, persistent sore throat, night sweats, diarrhea, joint/muscle aches, enlarged lymph nodes).
| HIV infection | |
| B20 | Human immunodeficiency virus [HIv] disease |
| B97.35 | Human immunodeficiency virus, type 2 [HIV 2] as the cause of diseases classified elsewhere |
| O98.7 | Human immunodeficiency virus [HIv] disease complicating pregnancy, childbirth and the puerperium |
| O98.71 | Human immunodeficiency virus [HIv] disease complicating pregnancy |
| O98.711 | Human immunodeficiency virus [HIv] disease complicating pregnancy, first trimester |
| O98.712 | Human immunodeficiency virus [HIv] disease complicating pregnancy, second trimester |
| O98.713 | Human immunodeficiency virus [HIv] disease complicating pregnancy, third trimester |
| O98.719 | Human immunodeficiency virus [HIv] disease complicating pregnancy, unspecified trimester |
| O98.72 | Human immunodeficiency virus [HIv] disease complicating childbirth |
| O98.73 | Human immunodeficiency virus [HIv] disease complicating the puerperium |
| Z21 | Asymptomatic human immunodeficiency virus [HIv] infection status |
| 0-9 | A-Z |
|---|---|
| B20 | Human immunodeficiency virus [HIv] disease |
| B97.35 | Human immunodeficiency virus, type 2 [HIV 2] as the cause of diseases classified elsewhere |
| O98.7 | Human immunodeficiency virus [HIv] disease complicating pregnancy, childbirth and the puerperium |
| O98.71 | Human immunodeficiency virus [HIv] disease complicating pregnancy |
| O98.711 | Human immunodeficiency virus [HIv] disease complicating pregnancy, first trimester |
| O98.712 | Human immunodeficiency virus [HIv] disease complicating pregnancy, second trimester |
| O98.713 | Human immunodeficiency virus [HIv] disease complicating pregnancy, third trimester |
| O98.719 | Human immunodeficiency virus [HIv] disease complicating pregnancy, unspecified trimester |
| O98.72 | Human immunodeficiency virus [HIv] disease complicating childbirth |
| O98.73 | Human immunodeficiency virus [HIv] disease complicating the puerperium |
| Z21 | Asymptomatic human immunodeficiency virus [HIv] infection status |
Formulary Reference Tool