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TECENTRIQ (ATEZOLIZUMAB)
- HR negative, HEr2 negative, Pd-l1 positive breast cancer
- Non-small cell lung cancer
- Small cell lung carcinoma
- Transitional cell carcinoma of the urinary tract
1,200 mg/20 mL (60 mg/mL) intravenous solution
- Infuse 1,200 mg over 60 minute(s) by intravenous route every 3 weeks
840 mg/14 mL (60 mg/mL) intravenous solution
- Infuse 840 mg over 60 minute(s) by intravenous route on days 1 and 15Of a 28 day treatment cycle
HR negative, HEr2 negative, Pd-l1 positive breast cancer
- Infuse 840 mg over 60 minute(s) by intravenous route on days 1 and 15Of a 28 day treatment cycle
- Infuse 840 mg over 30 minute(s) by intravenous route on days 1 and 15Of a 28 day treatment cycle
Non-small cell lung cancer
- Infuse 1,200 mg over 60 minute(s) by intravenous route every 3 weeks
- Infuse 1,200 mg over 30 minute(s) by intravenous route every 3 weeks
- Infuse 1,680 mg over 60 minute(s) by intravenous route every 4 weeks
- Infuse 1,680 mg over 30 minute(s) by intravenous route every 4 weeks
Small cell lung carcinoma
- Infuse 1,200 mg over 60 minute(s) by intravenous route every 3 weeks
- Infuse 1,200 mg over 30 minute(s) by intravenous route every 3 weeks
- Infuse 1,680 mg over 60 minute(s) by intravenous route every 4 weeks
- Infuse 1,680 mg over 30 minute(s) by intravenous route every 4 weeks
Transitional cell carcinoma of the urinary tract
- Infuse 1,200 mg over 60 minute(s) by intravenous route every 3 weeks
- Infuse 1,200 mg over 30 minute(s) by intravenous route every 3 weeks
- Infuse 1,680 mg over 60 minute(s) by intravenous route every 4 weeks
- Infuse 1,680 mg over 30 minute(s) by intravenous route every 4 weeks
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- None
Severe
Moderate
- None
- Interstitial pneumonitis
- Lactating mother
- Myocarditis
Contraindicated
- Acute hepatitis
- Adrenal cortical insufficiency
- Colitis
- Hyperthyroidism
- Hypophysitis
- Hypothyroidism
- Myositis
- Nephritis
- Pancreatitis
- Pregnancy
Severe
Moderate
- Type 1 diabetes mellitus
TECENTRIQ (ATEZOLIZUMAB)
- HR negative, HEr2 negative, Pd-l1 positive breast cancer
- Non-small cell lung cancer
- Small cell lung carcinoma
- Transitional cell carcinoma of the urinary tract
- Dysesthesia
- Infection
- Polyneuropathy
- Anorexia
- Constipation
- Cough
- Diarrhea
- Fatigue
- Fever
- Nausea
- Paresthesia
- Peripheral neuropathy
- Peripheral sensory neuropathy
- Urinary tract infection
More Frequent
Severe
Less Severe
- Abnormal hepatic function tests
- Acute abdominal pain
- Acute renal failure
- Bacterial sepsis
- Colitis
- Dyspnea
- Gastrointestinal obstruction
- Hematuria
- Hepatitis
- Hyperbilirubinemia
- Hypersensitivity pneumonitis
- Hyperthyroidism
- Hypothyroidism
- Increased alanine transaminase
- Increased aspartate transaminase
- Interstitial lung disease
- Neutropenic disorder
- Pleural effusions
- Pneumonia
- Urinary tract obstruction
- Venous thrombosis
- Acute confusion
- Peripheral edema
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acquired hemolytic anemia
- Adrenal cortical insufficiency
- Bullous dermatitis
- Diabetes mellitus
- Encephalitis
- Erythema multiforme
- Guillain-barre syndrome
- Herpes simplex encephalitis
- Histiocytic necrotizing lymphadenitis
- Hypophysitis
- Idiopathic thrombocytopenic purpura
- Interstitial nephritis
- Meningitis
- Muscle weakness
- Mycobacteriosis
- Myocarditis
- Myositis
- Non-infective meningitis
- Pancreatitis
- Pemphigoid
- Rhabdomyolysis
- Sepsis
- Stevens-johnson syndrome
- Toxic epidermal necrolysis
- Vasculitis
Less Severe
- Elevated serum amylase
- Elevated serum lipase
- Facial palsy
- Ocular inflammation
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Atezolizumab
No established pediatric safety and efficacy.
- 1 Day – 18 Years
- No established pediatric safety and efficacy.
Atezolizumab
- Severity Level:
D
- Additional Notes: Based on drug pharmacology developmental toxicity is possible.
Contraindicated
Atezolizumab
Insuff data avail;Mfg does not rec nursing during and 5 mo after last dose
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Insuff data avail;Mfg does not rec nursing during and 5 mo after last dose |
Precaution Exists
None
General | Excretion Potential | Effect on Infant | Notes |
None |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
HR negative, HEr2 negative, Pd-l1 positive breast cancer | |
C50.01 | Malignant neoplasm of nipple and areola, female |
C50.11 | Malignant neoplasm of central portion of breast, female |
C50.111 | Malignant neoplasm of central portion of right female breast |
C50.112 | Malignant neoplasm of central portion of left female breast |
C50.119 | Malignant neoplasm of central portion of unspecified female breast |
C50.21 | Malignant neoplasm of upper-inner quadrant of breast, female |
C50.211 | Malignant neoplasm of upper-inner quadrant of right female breast |
C50.212 | Malignant neoplasm of upper-inner quadrant of left female breast |
C50.219 | Malignant neoplasm of upper-inner quadrant of unspecified female breast |
C50.31 | Malignant neoplasm of lower-inner quadrant of breast, female |
C50.311 | Malignant neoplasm of lower-inner quadrant of right female breast |
C50.312 | Malignant neoplasm of lower-inner quadrant of left female breast |
C50.319 | Malignant neoplasm of lower-inner quadrant of unspecified female breast |
C50.41 | Malignant neoplasm of upper-outer quadrant of breast, female |
C50.411 | Malignant neoplasm of upper-outer quadrant of right female breast |
C50.412 | Malignant neoplasm of upper-outer quadrant of left female breast |
C50.419 | Malignant neoplasm of upper-outer quadrant of unspecified female breast |
C50.51 | Malignant neoplasm of lower-outer quadrant of breast, female |
C50.511 | Malignant neoplasm of lower-outer quadrant of right female breast |
C50.512 | Malignant neoplasm of lower-outer quadrant of left female breast |
C50.519 | Malignant neoplasm of lower-outer quadrant of unspecified female breast |
C50.61 | Malignant neoplasm of axillary tail of breast, female |
C50.611 | Malignant neoplasm of axillary tail of right female breast |
C50.612 | Malignant neoplasm of axillary tail of left female breast |
C50.619 | Malignant neoplasm of axillary tail of unspecified female breast |
C50.81 | Malignant neoplasm of overlapping sites of breast, female |
C50.811 | Malignant neoplasm of overlapping sites of right female breast |
C50.812 | Malignant neoplasm of overlapping sites of left female breast |
C50.819 | Malignant neoplasm of overlapping sites of unspecified female breast |
C50.91 | Malignant neoplasm of breast of unspecified site, female |
C50.911 | Malignant neoplasm of unspecified site of right female breast |
C50.912 | Malignant neoplasm of unspecified site of left female breast |
C50.919 | Malignant neoplasm of unspecified site of unspecified female breast |
Z17.1 | Estrogen receptor negative status [Er-] |
Non-small cell lung cancer | |
C34 | Malignant neoplasm of bronchus and lung |
C34.0 | Malignant neoplasm of main bronchus |
C34.00 | Malignant neoplasm of unspecified main bronchus |
C34.01 | Malignant neoplasm of right main bronchus |
C34.02 | Malignant neoplasm of left main bronchus |
C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
Small cell lung carcinoma | |
C34 | Malignant neoplasm of bronchus and lung |
C34.0 | Malignant neoplasm of main bronchus |
C34.00 | Malignant neoplasm of unspecified main bronchus |
C34.01 | Malignant neoplasm of right main bronchus |
C34.02 | Malignant neoplasm of left main bronchus |
C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
Transitional cell carcinoma of the urinary tract | |
C65 | Malignant neoplasm of renal pelvis |
C65.1 | Malignant neoplasm of right renal pelvis |
C65.2 | Malignant neoplasm of left renal pelvis |
C65.9 | Malignant neoplasm of unspecified renal pelvis |
C66 | Malignant neoplasm of ureter |
C66.1 | Malignant neoplasm of right ureter |
C66.2 | Malignant neoplasm of left ureter |
C66.9 | Malignant neoplasm of unspecified ureter |
C67 | Malignant neoplasm of bladder |
C67.0 | Malignant neoplasm of trigone of bladder |
C67.1 | Malignant neoplasm of dome of bladder |
C67.2 | Malignant neoplasm of lateral wall of bladder |
C67.3 | Malignant neoplasm of anterior wall of bladder |
C67.4 | Malignant neoplasm of posterior wall of bladder |
C67.5 | Malignant neoplasm of bladder neck |
C67.6 | Malignant neoplasm of ureteric orifice |
C67.8 | Malignant neoplasm of overlapping sites of bladder |
C67.9 | Malignant neoplasm of bladder, unspecified |
0-9 | A-Z |
---|---|
C34 | Malignant neoplasm of bronchus and lung |
C34 | Malignant neoplasm of bronchus and lung |
C34.0 | Malignant neoplasm of main bronchus |
C34.0 | Malignant neoplasm of main bronchus |
C34.00 | Malignant neoplasm of unspecified main bronchus |
C34.00 | Malignant neoplasm of unspecified main bronchus |
C34.01 | Malignant neoplasm of right main bronchus |
C34.01 | Malignant neoplasm of right main bronchus |
C34.02 | Malignant neoplasm of left main bronchus |
C34.02 | Malignant neoplasm of left main bronchus |
C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
C39.9 | Malignant neoplasm of lower respiratory tract, part unspecified |
C50.01 | Malignant neoplasm of nipple and areola, female |
C50.11 | Malignant neoplasm of central portion of breast, female |
C50.111 | Malignant neoplasm of central portion of right female breast |
C50.112 | Malignant neoplasm of central portion of left female breast |
C50.119 | Malignant neoplasm of central portion of unspecified female breast |
C50.21 | Malignant neoplasm of upper-inner quadrant of breast, female |
C50.211 | Malignant neoplasm of upper-inner quadrant of right female breast |
C50.212 | Malignant neoplasm of upper-inner quadrant of left female breast |
C50.219 | Malignant neoplasm of upper-inner quadrant of unspecified female breast |
C50.31 | Malignant neoplasm of lower-inner quadrant of breast, female |
C50.311 | Malignant neoplasm of lower-inner quadrant of right female breast |
C50.312 | Malignant neoplasm of lower-inner quadrant of left female breast |
C50.319 | Malignant neoplasm of lower-inner quadrant of unspecified female breast |
C50.41 | Malignant neoplasm of upper-outer quadrant of breast, female |
C50.411 | Malignant neoplasm of upper-outer quadrant of right female breast |
C50.412 | Malignant neoplasm of upper-outer quadrant of left female breast |
C50.419 | Malignant neoplasm of upper-outer quadrant of unspecified female breast |
C50.51 | Malignant neoplasm of lower-outer quadrant of breast, female |
C50.511 | Malignant neoplasm of lower-outer quadrant of right female breast |
C50.512 | Malignant neoplasm of lower-outer quadrant of left female breast |
C50.519 | Malignant neoplasm of lower-outer quadrant of unspecified female breast |
C50.61 | Malignant neoplasm of axillary tail of breast, female |
C50.611 | Malignant neoplasm of axillary tail of right female breast |
C50.612 | Malignant neoplasm of axillary tail of left female breast |
C50.619 | Malignant neoplasm of axillary tail of unspecified female breast |
C50.81 | Malignant neoplasm of overlapping sites of breast, female |
C50.811 | Malignant neoplasm of overlapping sites of right female breast |
C50.812 | Malignant neoplasm of overlapping sites of left female breast |
C50.819 | Malignant neoplasm of overlapping sites of unspecified female breast |
C50.91 | Malignant neoplasm of breast of unspecified site, female |
C50.911 | Malignant neoplasm of unspecified site of right female breast |
C50.912 | Malignant neoplasm of unspecified site of left female breast |
C50.919 | Malignant neoplasm of unspecified site of unspecified female breast |
C65 | Malignant neoplasm of renal pelvis |
C65.1 | Malignant neoplasm of right renal pelvis |
C65.2 | Malignant neoplasm of left renal pelvis |
C65.9 | Malignant neoplasm of unspecified renal pelvis |
C66 | Malignant neoplasm of ureter |
C66.1 | Malignant neoplasm of right ureter |
C66.2 | Malignant neoplasm of left ureter |
C66.9 | Malignant neoplasm of unspecified ureter |
C67 | Malignant neoplasm of bladder |
C67.0 | Malignant neoplasm of trigone of bladder |
C67.1 | Malignant neoplasm of dome of bladder |
C67.2 | Malignant neoplasm of lateral wall of bladder |
C67.3 | Malignant neoplasm of anterior wall of bladder |
C67.4 | Malignant neoplasm of posterior wall of bladder |
C67.5 | Malignant neoplasm of bladder neck |
C67.6 | Malignant neoplasm of ureteric orifice |
C67.8 | Malignant neoplasm of overlapping sites of bladder |
C67.9 | Malignant neoplasm of bladder, unspecified |
Z17.1 | Estrogen receptor negative status [Er-] |
Formulary Reference Tool