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FYCOMPA (PERAMPANEL)
- Focal epilepsy
- Tonic-clonic epilepsy treatment adjunct
10 mg tablet
- 1 tablet (10 mg) by oral route once daily at bedtime
12 mg tablet
- 1 tablet (12 mg) by oral route once daily at bedtime
2 mg tablet
- 1 tablet (2 mg) by oral route once daily at bedtime
4 mg tablet
- 1 tablet (4 mg) by oral route once daily at bedtime
6 mg tablet
- 1 tablet (6 mg) by oral route once daily at bedtime
8 mg tablet
- 1 tablet (8 mg) by oral route once daily at bedtime
0.5 mg/mL oral suspension
- 16 milliliters (8 mg) by oral route once daily at bedtime
Focal epilepsy
- 1 tablet (2 mg) by oral route once daily at bedtime
- 4 milliliters (2 mg) by oral route once daily at bedtime
- 8 milliliters (4 mg) by oral route once daily at bedtime
- 1 tablet (4 mg) by oral route once daily at bedtime
- 2 tablets (4 mg) by oral route once daily at bedtime
- 1 tablet (6 mg) by oral route once daily at bedtime
- 12 milliliters (6 mg) by oral route once daily at bedtime
- 16 milliliters (8 mg) by oral route once daily at bedtime
- 2 tablets (8 mg) by oral route once daily at bedtime
- 1 tablet (8 mg) by oral route once daily at bedtime
- 1 tablet (10 mg) by oral route once daily at bedtime
- 2 tablets (12 mg) by oral route once daily at bedtime
- 1 tablet (12 mg) by oral route once daily at bedtime
- 24 milliliters (12 mg) by oral route once daily at bedtime
Tonic-clonic epilepsy treatment adjunct
- 1 tablet (2 mg) by oral route once daily at bedtime
- 4 milliliters (2 mg) by oral route once daily at bedtime
- 8 milliliters (4 mg) by oral route once daily at bedtime
- 1 tablet (4 mg) by oral route once daily at bedtime
- 2 tablets (4 mg) by oral route once daily at bedtime
- 1 tablet (6 mg) by oral route once daily at bedtime
- 12 milliliters (6 mg) by oral route once daily at bedtime
- 16 milliliters (8 mg) by oral route once daily at bedtime
- 2 tablets (8 mg) by oral route once daily at bedtime
- 1 tablet (8 mg) by oral route once daily at bedtime
- 1 tablet (10 mg) by oral route once daily at bedtime
- 2 tablets (12 mg) by oral route once daily at bedtime
- 1 tablet (12 mg) by oral route once daily at bedtime
- 24 milliliters (12 mg) by oral route once daily at bedtime
- None
Contraindicated
- Altavera (28)
- Alyacen 1/35 (28)
- Alyacen 7/7/7 (28)
- Amethia
- Amethia Lo
- Amethyst
- Apri
- Aranelle (28)
- Aubra
- Aviane
- Azurette (28)
- Balziva (28)
- Beyaz
- Brevicon (28)
- Briellyn
- Camila
- Camrese
- Camrese Lo
- Caziant (28)
- Chateal
- Cryselle (28)
- Cyclafem 1/35 (28)
- Cyclafem 7/7/7 (28)
- Cyclessa (28)
- Dasetta 1/35 (28)
- Dasetta 7/7/7 (28)
- Daysee
- desog-e.estradiol/e.estradiol
- Desogen
- desogestrel-ethinyl estradiol
- drospirenone-e.estradiol-lm.FA
- drospirenone-ethinyl estradiol
- Elinest
- Emoquette
- Enpresse
- Enskyce
- Errin
- Estarylla
- estradiol valerate-dienogest
- Estrostep Fe-28
- ethynodiol diac-eth estradiol
- etonogestrel
- etonogestrel-ethinyl estradiol
- Falmina (28)
- Femcon Fe
- Generess Fe
- Gianvi (28)
- Gildagia
- Gildess
- Gildess Fe
- Heather
- Introvale
- Jencycla
- Jolessa
- Jolivette
- Junel 1.5/30 (21)
- Junel 1/20 (21)
- Junel Fe 1.5/30 (28)
- Junel Fe 1/20 (28)
- Kariva (28)
- Kelnor 1/35 (28)
- Kurvelo
- L norgest&E estradiol-E estrad
- Larin 1/20 (21)
- Larin Fe
- Leena 28
- Lessina
- Levonest (28)
- levonorg-eth estrad triphasic
- levonorgestrel
- levonorgestrel-ethinyl estrad
- Levora 0.15/30 (28)
- Levora-28
- Lo Loestrin Fe
- Loestrin 1.5/30 (21)
- Loestrin 1/20 (21)
- Loestrin Fe 1.5/30 (28)
- Loestrin Fe 1/20 (28)
- Lomedia 24 Fe
- Loryna (28)
- Loseasonique
- Low-ogestrel (28)
- Lutera (28)
- Lyza
- Marlissa
- Microgestin 1.5/30 (21)
- Microgestin 1/20 (21)
- Microgestin Fe 1.5/30 (28)
- Microgestin Fe 1/20 (28)
- Minastrin 24 Fe
- Mircette (28)
- Mirena
- Modicon (28)
- Mono-linyah
- Mononessa (28)
- My Way
- Myzilra
- Natazia
- Necon 0.5/35 (28)
- Necon 1/35 (28)
- Necon 1/50 (28)
- Necon 10/11 (28)
- Necon 7/7/7 (28)
- Nexplanon
- Next Choice One Dose
- Nor-qd
- Nora-be
- norelgestrom-ethinyl estradiol
- noreth-ethinyl estradiol-iron
- norethin-e.estradiol triphasic
- norethin-eth estrad biphasic
- norethindrone (contraceptive)
- norethindrone ac-eth estradiol
- norethindrone-e.estradiol-iron
- norethindrone-ethin estradiol
- norethindrone-mestranol
- norgestimate-ethinyl estradiol
- norgestrel-ethinyl estradiol
- Norinyl 1+35 (28)
- Norinyl 1+50 (28)
- Nortrel 0.5/35 (28)
- Nortrel 1/35 (21)
- Nortrel 1/35 (28)
- Nortrel 7/7/7 (28)
- Nuvaring
- Ocella
- Ogestrel (28)
- Orsythia
- Ortho Evra
- Ortho Micronor
- Ortho Tri-cyclen (28)
- Ortho Tri-cyclen Lo (28)
- Ortho-cept (28)
- Ortho-cyclen (28)
- Ortho-novum 1/35 (28)
- Ortho-novum 7/7/7 (28)
- Ovcon-35 (28)
- Philith
- Pimtrea (28)
- Pirmella
- Plan B One-step
- Portia
- Previfem
- Quartette
- Quasense
- Reclipsen (28)
- Safyral
- Seasonique
- Skyla
- Sprintec (28)
- Sronyx
- Syeda
- Tilia Fe
- Tri-estarylla
- Tri-legest Fe
- Tri-linyah
- Tri-norinyl (28)
- Tri-previfem (28)
- Tri-sprintec (28)
- Trinessa (28)
- Trivora (28)
- Velivet Triphasic Regimen (28)
- Vestura (28)
- Viorele (28)
- Vyfemla (28)
- Wera (28)
- Wymzya Fe
- Yasmin (28)
- Yaz 28
- Zarah
- Zenchent (28)
- Zenchent Fe
- Zeosa
- Zovia 1/35E (28)
- Zovia 1/50E (28)
Severe
Moderate
- isoniazid-rifamp-pyrazinamide
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- None
Contraindicated
- Aggressive behavior
- Alcohol intoxication
- Alcoholism
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Disease of liver
- Homicidal ideation
- Hostility
- Irritability
- Suicidal ideation
Severe
Moderate
- Gait abnormality
FYCOMPA (PERAMPANEL)
- Focal epilepsy
- Tonic-clonic epilepsy treatment adjunct
- Accidental fall
- Hostility
- Acute abdominal pain
- Aggressive behavior
- Ataxia
- Bruising
- Dizziness
- Drowsy
- Fatigue
- Gait abnormality
- General weakness
- Irritability
- Nausea
- Vertigo
- Vomiting
- Weight gain
More Frequent
Severe
Less Severe
- Hyponatremia
- Acute confusion
- Agitation
- Arthralgias
- Back pain
- Blurred vision
- Constipation
- Delusional disorder
- Diplopia
- Dysarthria
- Euphoria
- Hypesthesia
- Memory impairment
- Mood changes
- Myalgias
- Paranoid disorder
- Peripheral edema
- Sedation
- Symptoms of anxiety
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Delirium
- DRESS syndrome
- Drug-induced psychosis
- Eosinophilia
- Hallucinations
- Homicidal ideation
- Suicidal
- Suicidal ideation
Less Severe
- Behavioral disorders
- Personality disorders
- Skin rash
Contraindicated
None
Severe Precaution
Perampanel
Not studied age < 4 years. Risk of neurobehavioral impairment and mood changes. Theoretical risk of CNS changes.
Risk of mood changes, hostility, aggression, suicidal ideation. Monitor behavior. No safety information for treating generalized tonic-clonic seizure age < 12 years.
- 1 Day – 4 Years
- Not studied age < 4 years. Risk of neurobehavioral impairment and mood changes. Theoretical risk of CNS changes.
- Risk of mood changes, hostility, aggression, suicidal ideation. Monitor behavior. No safety information for treating generalized tonic-clonic seizure age < 12 years.
- 4 Years – 18 Years
- Not studied age < 4 years. Risk of neurobehavioral impairment and mood changes. Theoretical risk of CNS changes.
- Risk of mood changes, hostility, aggression, suicidal ideation. Monitor behavior. No safety information for treating generalized tonic-clonic seizure age < 12 years.
Management or Monitoring Precaution
None
Perampanel
- Severity Level:
2
- Additional Notes: Insuff human data avail;consider maternal benefit; animal data sugg dev tox
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Perampanel
Insufficient human data; excreted in rats
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human data; excreted in rats |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Perampanel
General-Maximum frequency for dosage increase is every 2 weeks. Neuro/Psych-Fall risk due to dizziness, gait disturbances, somnolence and fatigue. Monitor for psychiatric or abnormal behavior (e.g. aggression, hostility, irritability, homicidal ideation, suicidal ideation) at the start and during any dose titration. Renal-Titrate dose slowly with moderate impairment. Not recommended in severe CRF. Hepatic-Titrate dose slowly with moderate impairment. Not recommended in severe disease.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | N | Y | N | N |
BEERS: Y HEDIS: N STOPP: Y
No Known Risk
None
- Perampanel may cause or worsen mental/mood disorders. Tell your doctor right away if you or your family/caregiver notice any unusual behavior changes (including aggression, attempts to hurt others, impulsive actions) or other mental/mood changes (including anxiety, irritability, hostile/angry feelings, paranoia, hallucinations, delusions, thoughts of harming others). Be especially watchful for these symptoms when you first start this medication or when the dose is changed.<br /><br />These symptoms may also occur even after stopping perampanel. Do not drink alcoholic beverages while taking perampanel because alcohol may make these symptoms worse.
| Focal epilepsy | |
| G40.0 | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset |
| G40.00 | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, not intractable |
| G40.009 | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, not intractable, without status epilepticus |
| G40.01 | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, intractable |
| G40.019 | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, intractable, without status epilepticus |
| G40.1 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures |
| G40.10 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, not intractable |
| G40.109 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, not intractable, without status epilepticus |
| G40.11 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, intractable |
| G40.119 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, intractable, without status epilepticus |
| G40.2 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures |
| G40.20 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, not intractable |
| G40.209 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, not intractable, without status epilepticus |
| G40.21 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, intractable |
| G40.219 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, intractable, without status epilepticus |
| Tonic-clonic epilepsy treatment adjunct | |
| G40.3 | Generalized idiopathic epilepsy and epileptic syndromes |
| G40.30 | Generalized idiopathic epilepsy and epileptic syndromes, not intractable |
| G40.309 | Generalized idiopathic epilepsy and epileptic syndromes, not intractable, without status epilepticus |
| G40.31 | Generalized idiopathic epilepsy and epileptic syndromes, intractable |
| G40.319 | Generalized idiopathic epilepsy and epileptic syndromes, intractable, without status epilepticus |
| G40.4 | Other generalized epilepsy and epileptic syndromes |
| G40.40 | Other generalized epilepsy and epileptic syndromes, not intractable |
| G40.409 | Other generalized epilepsy and epileptic syndromes, not intractable, without status epilepticus |
| G40.41 | Other generalized epilepsy and epileptic syndromes, intractable |
| G40.419 | Other generalized epilepsy and epileptic syndromes, intractable, without status epilepticus |
| 0-9 | A-Z |
|---|---|
| G40.0 | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset |
| G40.00 | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, not intractable |
| G40.009 | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, not intractable, without status epilepticus |
| G40.01 | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, intractable |
| G40.019 | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, intractable, without status epilepticus |
| G40.1 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures |
| G40.10 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, not intractable |
| G40.109 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, not intractable, without status epilepticus |
| G40.11 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, intractable |
| G40.119 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, intractable, without status epilepticus |
| G40.2 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures |
| G40.20 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, not intractable |
| G40.209 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, not intractable, without status epilepticus |
| G40.21 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, intractable |
| G40.219 | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, intractable, without status epilepticus |
| G40.3 | Generalized idiopathic epilepsy and epileptic syndromes |
| G40.30 | Generalized idiopathic epilepsy and epileptic syndromes, not intractable |
| G40.309 | Generalized idiopathic epilepsy and epileptic syndromes, not intractable, without status epilepticus |
| G40.31 | Generalized idiopathic epilepsy and epileptic syndromes, intractable |
| G40.319 | Generalized idiopathic epilepsy and epileptic syndromes, intractable, without status epilepticus |
| G40.4 | Other generalized epilepsy and epileptic syndromes |
| G40.40 | Other generalized epilepsy and epileptic syndromes, not intractable |
| G40.409 | Other generalized epilepsy and epileptic syndromes, not intractable, without status epilepticus |
| G40.41 | Other generalized epilepsy and epileptic syndromes, intractable |
| G40.419 | Other generalized epilepsy and epileptic syndromes, intractable, without status epilepticus |
Formulary Reference Tool