HEPLISAV-B (hepatitis B vaccine recombinant/vaccine adjuvant CpG 1018/PF)

Rare / Very Rare

Severe

• Abnormal hepatic function tests

• Anaphylaxis

• Angioedema

• Apnea

• Bell's palsy

• Bronchospastic pulmonary disease

• Encephalitis

• Encephalopathy

• Erythema multiforme

• Erythema nodosum

• Guillain-barre syndrome

• Herpes zoster

• Lichen planus

• Meningitis

• Muscle weakness

• Myelitis

• Optic neuritis

• Purpura

• Seizure disorder

• Serum sickness

• Stevens-johnson syndrome

• Syncope

• Thrombocytopenic disorder

• Vasculitis

Less Severe

• Abdominal pain with cramps

• Agitation

• Alopecia

• Anorexia

• Arthralgias

• Arthritis

• Back pain

• Chills

• Conjunctivitis

• Constipation

• Diarrhea

• Drowsy

• Dyspepsia

• Earache

• Ecchymosis

• Eczema

• Flu-like symptoms

• Flushing

• General weakness

• Hyperhidrosis

• Hypesthesia

• Hypotension

• Insomnia

• Irritability

• Keratitis

• Lymphadenopathy

• Malaise

• Migraine

• Myalgias

• Nausea

• Neck pain

• Neck stiffness

• Palpitations

• Paresthesia

• Peripheral sensory neuropathy

• Petechiae

• Pruritus of skin

• Shoulder pain

• Skin rash

• Tachycardia

• Tinnitus

• Upper respiratory infection

• Urticaria

• Visual changes

• Vomiting