SYMFI (efavirenz/lamivudine/tenofovir disoproxil fumarate)

Moderate

• Advil

• Advil Allergy Sinus

• Advil Allergy-congestion Rlf

• Advil Cold & Sinus

• Advil Congestion Relief

• Advil Liqui-gel

• Advil Migraine

• Advil Pm

• Advil Pm Liqui-gels

• afatinib

• Aleve

• Aleve Cold & Sinus

• Aleve Sinus & Headache

• Aleve-d Sinus & Cold

• Aleve-d Sinus & Headache

• All Day Pain Relief

• All Day Pain Relief Sinus & Co

• All Day Relief

• amlodipine-atorvastatin

• amoxicil-clarithromy-lansopraz

• Anaprox

• Anaprox Ds

• Ansaid

• Arthrotec 50

• atorvastatin

• Biaxin

• Biaxin Xl

• Biaxin Xl Pak

• Caduet

• Caldolor

• Cambia

• Cancidas

• caspofungin

• Cataflam

• Celebrex

• celecoxib

• Child Ibuprofen

• Children's Advil

• Children's Ibu-drops

• Children's Ibuprofen

• Children's Medi-profen

• Children's Motrin

• Children's Profen Ib

• chlorphen-phenyleph-ibuprofen

• chlorphen-pseudoeph-ibuprofen

• cilostazol

• clarithromycin

• Cold & Sinus Pain Relief

• Cold-sinus Relief

• Crixivan

• Daypro

• diclofenac epolamine

• diclofenac potassium

• diclofenac sodium

• diclofenac submicronized

• diclofenac-misoprostol

• didanosine

• Diskets

• Dolophine

• Duexis

• Ec-naprosyn

• etodolac

• ezetimibe-atorvastatin

• ezetimibe-simvastatin

• Feldene

• fenoprofen

• Flanax

• Flector

• flurbiprofen

• fosamprenavir

• Gilotrif

• hydrocodone-ibuprofen

• I-prin

• Ibu-drops

• Ibudone

• ibuprofen

• Ibuprofen Cold

• Ibuprofen Cold-sinus(with Pse)

• Ibuprofen Ib

• Ibuprofen Jr Strength

• ibuprofen lysine (PF)

• Ibuprofen Pm

• ibuprofen-diphenhydramine

• ibuprofen-diphenhydramine HCl

• ibuprofen-famotidine

• ibuprofen-oxycodone

• ibuprofen-phenylephrine HCl

• indinavir

• Indocin

• indomethacin

• indomethacin sodium

• Infant's Ibuprofen

• Infant's Medi-profen

• Infant's Motrin

• Infants Ibu-drops

• Infants Profenib

• Invirase

• Kaletra

• ketoprofen

• ketorolac

• Lexiva

• Lipitor

• Liptruzet

• lopinavir-ritonavir

• Medi-profen

• Mediproxen

• mefenamic acid

• meloxicam

• methadone

• Methadone Intensol

• Methadose

• Midol (naproxen)

• Mobic

• Motrin Ib

• Motrin Pm

• Mycobutin

• nabumetone

• Nalfon

• Naprelan Cr

• Naprosyn

• naproxen

• naproxen sodium

• naproxen-esomeprazole

• naproxen-pseudoephedrine

• Neoprofen (ibuprofen Lysn)(pf)

• niacin-simvastatin

• Omeclamox-pak

• omeprazole-clarith-amoxicillin

• oxaprozin

• Pennsaid

• piroxicam

• Pletal

• Ponstel

• Pravachol

• pravastatin

• Prevpac

• Provil

• pseudoephedrine-ibuprofen

• Reprexain

• rifabutin

• saquinavir mesylate

• Simcor

• simvastatin

• Sinus & Cold-d

• Solaraze

• Sprix

• sulindac

• tolmetin

• Vicoprofen

• Videx 2 Gram Pediatric

• Videx 4 Gram Pediatric

• Videx Ec

• Vimovo

• Voltaren-xr

• Vytorin 10-10

• Vytorin 10-20

• Vytorin 10-40

• Vytorin 10-80

• Wal-profen

• Wal-profen Cold-sinus

• Wal-proxen

• Zipsor

• Zocor

• Zorvolex

Moderate

• Aggressive behavior

• CYp2b6*6/*6 genotype

• Hypercholesterolemia

• Hypertriglyceridemia

• Insomnia

• Kidney disease with likely reduction in GFR

• Osteopenia

• Seizure disorder

Efavirenz

• Severity Level:

  2

• Additional Notes: No fda cat;art preg registry data show no increased risk for major birth defects

Lamivudine

• Severity Level:

  2

• Additional Notes: No fda cat;art preg registry data show no increased risk for major birth defects

Tenofovir

• Severity Level:

  2

• Additional Notes: Available human data show no increased risk for major birth defects

Contraindicated

Efavirenz

Cdc does not recommend breastfeeding in hiv-positive women

Avoid breastfeeding in hiv positive women per cdc

General	Excretion Potential	Effect on Infant	Notes
Drug should not be given to breast feeding mothers	Excreted	Not known; no or inclusive data	Cdc does not recommend breastfeeding in hiv-positive women

Lamivudine

Cdc does not recommend breastfeeding in hiv-positive women

Avoid breastfeeding in hiv positive women per cdc

General	Excretion Potential	Effect on Infant	Notes
Drug should not be given to breast feeding mothers	Excreted	Not known; no or inclusive data	Avoid breastfeeding in hiv positive women per cdc

Precaution Exists

Tenofovir

Limited data suggest no known adverse effects in nursing infant

General	Excretion Potential	Effect on Infant	Notes
Evaluate use carefully	Excreted	Not known; no or inclusive data	Limited data suggest no known adverse effects in nursing infant

No Known Risk

None

General	Excretion Potential	Effect on Infant	Notes
			None

Contraindicated

None

Precaution Exists

Tenofovir Disoproxil

Renal-Adjust dosing interval for CrCL<50mL/min. Fixed dose combinations containing tenofovir are not appropriate if dose adjustment is required. Musculoskeletal-Decreases in bone mineral density have been observed. Consider calcium and vitamin D3 supplementation.

Organ / System	HEP	REN	CARD	ENDO	NEURO / PSYCH	PULM
Increased Risk / Adverse Effects	Y	Y	Y	N	N	N

BEERS: N     HEDIS: N     STOPP: N

No Known Risk

None

0-9	A-Z
B20	Human immunodeficiency virus [HIv] disease
B97.35	Human immunodeficiency virus, type 2 [HIV 2] as the cause of diseases classified elsewhere
O98.7	Human immunodeficiency virus [HIv] disease complicating pregnancy, childbirth and the puerperium
O98.71	Human immunodeficiency virus [HIv] disease complicating pregnancy
O98.711	Human immunodeficiency virus [HIv] disease complicating pregnancy, first trimester
O98.712	Human immunodeficiency virus [HIv] disease complicating pregnancy, second trimester
O98.713	Human immunodeficiency virus [HIv] disease complicating pregnancy, third trimester
O98.719	Human immunodeficiency virus [HIv] disease complicating pregnancy, unspecified trimester
O98.72	Human immunodeficiency virus [HIv] disease complicating childbirth
O98.73	Human immunodeficiency virus [HIv] disease complicating the puerperium
Z21	Asymptomatic human immunodeficiency virus [HIv] infection status