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ZYNTEGLO (betibeglogene autotemcel)
- anemia due to beta-thalassemia
2 x 10exp6 to 20 x 10exp6 cell/mL intravenous suspension
- Dosage information is not available
- None
Contraindicated
- None
Severe
Moderate
- None
- Lactation
Contraindicated
- None
Severe
Moderate
- None
ZYNTEGLO (betibeglogene autotemcel)
- anemia due to beta-thalassemia
- Anemia
- Leukopenia
- Lymphopenia
- Neutropenic disorder
- Thrombocytopenic disorder
- Acute abdominal pain
- Alopecia
- Constipation
- Cough
- Epistaxis
- Fever
- Headache disorder
- Musculoskeletal pain
- Nausea
- Pruritus of skin
- Stomatitis
- Vomiting
More Frequent
Severe
Less Severe
- Chronic heart failure
- Dyspnea
- Hepatic veno-occlusive disease
- Hyperbilirubinemia
- Hypertension
- Hypokalemia
- Hyponatremia
- Hypophosphatemia
- Hypoxia
- Increased alanine transaminase
- Pneumonia
- Sepsis
- Viral infection
- Anorexia
- Diarrhea
- Dyschromia
- Fatigue
- Hyperglycemia
- Pain in oropharynx
- Pharyngitis
- Rhinitis
- Skin rash
- Upper respiratory infection
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Malignancy
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Betibeglogene
Safety and efficacy not established in children less than 4 years of age.
- 1 Day – 4 Years
- Safety and efficacy not established in children less than 4 years of age.
Betibeglogene Autotemcel
- Severity Level:
2
- Additional Notes: Insufficient human data on developmental toxicity risk
Contraindicated
Betibeglogene Autotemcel
Insuff data avail; manufacturer does not rec
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Insuff data avail; manufacturer does not rec |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Anemia in beta thalassemia | |
| D56.1 | Beta thalassemia |
| D56.2 | Delta-beta thalassemia |
| D56.3 | Thalassemia minor |
| D56.5 | Hemoglobin e-beta thalassemia |
| 0-9 | A-Z |
|---|---|
| D56.1 | Beta thalassemia |
| D56.2 | Delta-beta thalassemia |
| D56.3 | Thalassemia minor |
| D56.5 | Hemoglobin e-beta thalassemia |
Formulary Reference Tool