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NEXAVAR (SORAFENIB TOSYLATE)
- Differentiated thyroid carcinoma
- Liver cell carcinoma
- Renal cell carcinoma
200 mg tablet
- 2 tablets (400 mg) by oral route 2 times per day
Differentiated thyroid carcinoma
- 1 tablet (200 mg) by oral route once daily
- 1 tablet (200 mg) by oral route 2 times per day
- 2 tablets (400 mg) by oral route 2 times per day
Liver cell carcinoma
- 1 tablet (200 mg) by oral route once daily
- 2 tablets (400 mg) by oral route 2 times per day
- 2 tablets (400 mg) by oral route every other day
- 2 tablets (400 mg) by oral route once daily
Renal cell carcinoma
- 1 tablet (200 mg) by oral route once daily
- 2 tablets (400 mg) by oral route 2 times per day
- 2 tablets (400 mg) by oral route every other day
- 2 tablets (400 mg) by oral route once daily
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- amiodarone
- amiodarone in dextrose,iso-osm
- artemether-lumefantrine
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- calcium-mag-B complex-D3-hrb61
- carbamazepine
- Carbatrol
- Cerebyx
- clozapine
- Clozaril
- Coartem
- Cold & Flu Fighter
- Cordarone
- deferiprone
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- disopyramide
- Donnatal
- dronedarone
- droperidol
- enzalutamide
- Epitol
- Equetro
- Fatigue Relief Complex
- Fazaclo
- Ferriprox
- fosphenytoin
- Geodon
- isoniazid-rifamp-pyrazinamide
- Luminal
- Multaq
- Mycobutin
- Mysoline
- Nexterone
- Norpace
- Norpace Cr
- Orap
- Pacerone
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- pimozide
- primidone
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- St. John's wort
- Tegretol
- Tegretol Xr
- Versacloz
- vit C-St. John wort-elder-hb30
- Women's Complex
- Xtandi
- ziprasidone HCl
- ziprasidone mesylate
Severe
Moderate
- Ablavar
- Advair Diskus
- Advair Hfa
- alfuzosin
- Aloxi
- amantadine HCl
- Anzemet
- Apokyn
- apomorphine
- arsenic trioxide
- Astagraf Xl
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- azithromycin
- bedaquiline
- Betapace
- Betapace Af
- budesonide-formoterol
- Caprelsa
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- Celexa
- chloroquine phosphate
- chlorpromazine
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- citalopram
- Complera
- Corvert
- Coumadin
- crizotinib
- dasatinib
- Diskets
- Docefrez
- docetaxel
- dofetilide
- dolasetron
- Dolophine
- Dulera
- Edurant
- Effexor Xr
- emtricitab-rilpivirine-tenofov
- Eovist
- eribulin
- ezogabine
- Fareston
- felbamate
- Felbatol
- flecainide
- fluticasone-salmeterol
- Foradil Aerolizer
- formoterol fumarate
- foscarnet
- Foscavir
- gadofosveset trisodium
- gadoxetate
- granisetron
- granisetron (PF)
- Granisol
- Halaven
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Hecoria
- ibutilide fumarate
- indapamide
- Invega
- Invega Sustenna
- Invirase
- isradipine
- Istodax
- Jantoven
- Kaletra
- lapatinib
- Levaquin
- Levaquin In 5 % Dextrose
- Levitra
- levofloxacin
- levofloxacin in D5W
- lithium carbonate
- lithium citrate
- Lithobid
- lopinavir-ritonavir
- methadone
- Methadone Intensol
- Methadose
- moexipril
- moexipril-hydrochlorothiazide
- mometasone-formoterol
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Nebupent
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- nilotinib
- norfloxacin
- Noroxin
- Noxafil
- octreotide acetate
- ofloxacin
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- paliperidone
- paliperidone palmitate
- palonosetron
- pasireotide
- pazopanib
- Pentam
- pentamidine
- Perforomist
- posaconazole
- Potiga
- procainamide
- Prograf
- propafenone
- Qualaquin
- quetiapine
- quinine sulfate
- rilpivirine
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- romidepsin
- Rythmol
- salmeterol
- Sancuso
- Sandostatin
- Sandostatin Lar Depot
- saquinavir mesylate
- Serevent Diskus
- Seroquel
- Seroquel Xr
- Signifor
- Sirturo
- Soltamox
- Sorine
- sotalol
- Sotalol Af
- Sprycel
- sunitinib
- Sutent
- Symbicort
- tacrolimus
- tamoxifen
- Tasigna
- Taxotere
- telavancin
- tetrabenazine
- thioridazine
- Tikosyn
- tizanidine
- toremifene
- Trisenox
- Tykerb
- Uniretic
- Univasc
- Uroxatral
- vandetanib
- vardenafil
- vemurafenib
- venlafaxine
- Vfend
- Vfend Iv
- Vibativ
- voriconazole
- Votrient
- warfarin
- Xalkori
- Xenazine
- Zanaflex
- Zelboraf
- Zithromax
- Zithromax Tri-pak
- Zithromax Z-pak
- Zmax
- Zofran
- Zofran Odt
- Zuplenz
- Acute pancreatitis
- Arterial aneurysm
- Arterial dissection
- Congenital long QT syndrome
- Gastrointestinal perforation
- Lactating mother
- Prolonged QT interval
Contraindicated
- Abnormal hepatic function tests
- Acute myocardial infarction
- Angina
- Aseptic necrosis of jaw bone
- Drug-induced hepatitis
- Hemorrhage
- Hypokalemia
- Hypomagnesemia
- Invasive surgical procedure
- Myocardial ischemia
- Pregnancy
- Severe neutropenic disorder
- Severe thrombocytopenia
- Unstable angina pectoris
Severe
Moderate
- Anemia
- Bradycardia
- Chronic heart failure
- Depression
- Hypertension
- Hypocalcemia
- Hypophosphatemia
- Impaired wound healing
- Increased risk of bleeding
- Increased risk of bleeding due to coagulation disorder
NEXAVAR (SORAFENIB TOSYLATE)
- Differentiated thyroid carcinoma
- Liver cell carcinoma
- Renal cell carcinoma
- Anemia
- Depression
- Exfoliative dermatitis
- Gastrointestinal hemorrhage
- Hemorrhage
- Hypertension
- Hypophosphatemia
- Leukopenia
- Lymphopenia
- Neutropenic disorder
- Respiratory tract hemorrhage
- Thrombocytopenic disorder
- Acne vulgaris
- Acute abdominal pain
- Alopecia
- Anorexia
- Arthralgias
- Bone pain
- Constipation
- Diarrhea
- Dry skin
- Dyspepsia
- Dyspnea
- Eczema
- Elevated serum lipase
- Erectile dysfunction
- Erythema
- Fatigue
- Fever
- Flu-like symptoms
- Flushing
- General weakness
- Headache disorder
- Hoarseness
- Hypocalcemia
- Myalgias
- Nausea
- Palmar-plantar erythrodysesthesia
- Peripheral neuropathy
- Pruritus of skin
- Skin rash
- Stomatitis
- Vomiting
- Weight loss
More Frequent
Severe
Less Severe
- Acute myocardial infarction
- Chronic heart failure
- Hypothyroidism
- Myocardial ischemia
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute pancreatitis
- Anaphylaxis
- Angioedema
- Aseptic necrosis of jaw bone
- Cardiac arrhythmia
- Cholecystitis
- Dehydration
- Drug-induced hepatitis
- Erythema multiforme
- Gastrointestinal perforation
- Hepatic failure
- Hyperbilirubinemia
- Hypersensitivity drug reaction
- Hypertensive crisis
- Hypokalemia
- Hyponatremia
- Infection
- Interstitial lung disease
- Intracerebral hemorrhage
- Keratoacanthoma
- Nephrotic syndrome
- Posterior reversible encephalopathy syndrome
- Prolonged QT interval
- Renal failure
- Rhabdomyolysis
- Stevens-johnson syndrome
- Thromboembolic disorder
- Toxic epidermal necrolysis
- Transient cerebral ischemia
Less Severe
- Dysphagia
- Folliculitis
- Gastritis
- Gastroesophageal reflux disease
- Gynecomastia
- Hyperthyroidism
- Pain
- Proteinuria
- Rhinorrhea
- Tinnitus
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Sorafenib
Not studied in pediatrics. No safety and efficacy. Potential risk of bone and bone marrow abnormalities.
- 1 Day – 18 Years
- Not studied in pediatrics. No safety and efficacy. Potential risk of bone and bone marrow abnormalities.
Sorafenib
- Severity Level:
D
- Additional Notes: Use contraception during treatment and for 6 months after; may cause fetal harm
Contraindicated
Sorafenib
Insufficient human data avail; potential for serious adverse effects
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Insufficient human data avail; potential for serious adverse effects |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Differentiated thyroid carcinoma | |
| C73 | Malignant neoplasm of thyroid gland |
| Liver cell carcinoma | |
| C22.0 | Liver cell carcinoma |
| Renal cell carcinoma | |
| C64 | Malignant neoplasm of kidney, except renal pelvis |
| C64.1 | Malignant neoplasm of right kidney, except renal pelvis |
| C64.2 | Malignant neoplasm of left kidney, except renal pelvis |
| C64.9 | Malignant neoplasm of unspecified kidney, except renal pelvis |
| 0-9 | A-Z |
|---|---|
| C22.0 | Liver cell carcinoma |
| C64 | Malignant neoplasm of kidney, except renal pelvis |
| C64.1 | Malignant neoplasm of right kidney, except renal pelvis |
| C64.2 | Malignant neoplasm of left kidney, except renal pelvis |
| C64.9 | Malignant neoplasm of unspecified kidney, except renal pelvis |
| C73 | Malignant neoplasm of thyroid gland |
Formulary Reference Tool