ANGELIQ (ESTRADIOL/DROSPIRENONE)

Moderate

• A-hydrocort

• A-methapred

• Accupril

• Accuretic

• Aceon

• Advil

• Advil Allergy Sinus

• Advil Allergy-congestion Rlf

• Advil Cold & Sinus

• Advil Congestion Relief

• Advil Liqui-gel

• Advil Migraine

• Advil Pm

• Advil Pm Liqui-gels

• Alagesic Lq

• Aldactazide

• Aldactone

• Aleve

• Aleve Cold & Sinus

• Aleve Sinus & Headache

• Aleve-d Sinus & Cold

• Aleve-d Sinus & Headache

• Alka-seltzer Gold

• All Day Pain Relief

• All Day Pain Relief Sinus & Co

• All Day Relief

• Altace

• amiloride

• amiloride-hydrochlorothiazide

• amlodipine-benazepril

• amlodipine-olmesartan

• amlodipine-valsartan

• amlodipine-valsartan-hcthiazid

• amobarbital

• Amytal

• Anaprox

• Anaprox Ds

• Ansaid

• Anucort-hc

• Anusol-hc

• Aristospan Intra-articular

• Aristospan Intralesional

• Arthrotec 50

• Ascomp With Codeine

• Atacand

• Atacand Hct

• Avalide

• Avapro

• azilsartan med-chlorthalidone

• azilsartan medoxomil

• Azor

• Belladonna-phenobarbital

• benazepril

• benazepril-hydrochlorothiazide

• Benicar

• Benicar Hct

• betamethasone acet & sod phos

• Bivigam

• Brevital

• budesonide

• Bupap

• butabarbital

• Butalbital Compound W/codeine

• Butalbital Compound-codeine

• butalbital-acetaminop-caf-cod

• butalbital-acetaminophen

• butalbital-acetaminophen-caff

• butalbital-aspirin-caffeine

• Butisol

• Caldolor

• Cambia

• candesartan

• candesartan-hydrochlorothiazid

• Capacet

• captopril

• captopril-hydrochlorothiazide

• Carimune Nf Nanofiltered

• Cataflam

• Celebrex

• celecoxib

• Celestone Soluspan

• Ceralyte-70

• Ceraors 75

• Cerasport

• Cerasport Ex1

• Cerebyx

• Child Ibuprofen

• Children's Advil

• Children's Ibu-drops

• Children's Ibuprofen

• Children's Medi-profen

• Children's Motrin

• Children's Profen Ib

• chlorphen-phenyleph-ibuprofen

• chlorphen-pseudoeph-ibuprofen

• codeine-butalbital-ASA-caff

• Cold & Sinus Pain Relief

• Cold-sinus Relief

• Colocort

• Cortef

• Cortenema

• Cortifoam

• cortisone

• Cozaar

• Cytra K Crystals

• Cytra-3

• Cytra-k

• Daypro

• Depo-medrol

• dexamethasone

• Dexamethasone Intensol

• dexamethasone sodium phos (PF)

• dexamethasone sodium phosphate

• Dexpak 10 Day

• Dexpak 13 Day

• Dexpak 6 Day

• diclofenac epolamine

• diclofenac potassium

• diclofenac sodium

• diclofenac submicronized

• diclofenac-misoprostol

• Dilantin

• Dilantin Extended

• Dilantin Infatabs

• Dilantin Kapseal

• Dilantin-125

• Diovan Hct

• DM-GG-potassium citrate

• Donnatal

• Duexis

• Dyazide

• Dyrenium

• Ec-naprosyn

• Edarbi

• Edarbyclor

• Effer-k

• enalapril maleate

• enalapril-hydrochlorothiazide

• enalaprilat

• Entocort Ec

• Epaned

• eplerenone

• eprosartan

• eprosartan-hydrochlorothiazide

• Esgic

• ethotoin

• etodolac

• Evista

• Exforge

• Exforge Hct

• Ez Use Joint-tunnel-trigger

• Feldene

• fenoprofen

• Fioricet

• Fioricet With Codeine

• Fiorinal

• Fiorinal-codeine #3

• First-duke's

• First-mary's Mouthwash

• Flanax

• Flebogamma Dif

• Flector

• Flo-pred

• fludrocortisone

• flurbiprofen

• fosinopril

• fosinopril-hydrochlorothiazide

• fosphenytoin

• Gamastan S/d

• Gammagard Liquid

• Gammagard S-d (iga < 1 Mcg/ml)

• Gammagard S/d

• Gammaked

• Gammaplex

• Gamunex-c

• Grx Hicort 25

• Hemril-30

• heparin (porcine)

• heparin (porcine) in D5W

• heparin(porcine) in 0.45% NaCl

• heparin, porcine (PF)

• Hizentra

• hydrocodone-ibuprofen

• hydrocortisone

• hydrocortisone acetate

• hydrocortisone sod succ (PF)

• hydrocortisone sod succinate

• Hyperlyte Cr

• Hyzaar

• I-prin

• Ibu-drops

• Ibudone

• ibuprofen

• Ibuprofen Cold

• Ibuprofen Cold-sinus(with Pse)

• Ibuprofen Ib

• Ibuprofen Jr Strength

• ibuprofen lysine (PF)

• Ibuprofen Pm

• ibuprofen-diphenhydramine

• ibuprofen-diphenhydramine HCl

• ibuprofen-famotidine

• ibuprofen-oxycodone

• ibuprofen-phenylephrine HCl

• immune glob(IgG)(hum)-maltose

• immune globulin (human) (IgG)

• immune globulin(hum),capr(IgG)

• Indocin

• indomethacin

• indomethacin sodium

• Infant's Ibuprofen

• Infant's Medi-profen

• Infant's Motrin

• Infants Ibu-drops

• Infants Profenib

• Inspra

• irbesartan

• irbesartan-hydrochlorothiazide

• Juxtapid

• K-effervescent

• K-phos No 2

• K-phos Original

• K-phos-neutral

• K-tab

• Kaochlor

• Kenalog

• ketoprofen

• ketorolac

• Klor-con

• Klor-con 10

• Klor-con M10

• Klor-con M15

• Klor-con M20

• Klor-con/ef

• lisinopril

• lisinopril-hydrochlorothiazide

• lomitapide

• losartan

• losartan-hydrochlorothiazide

• Lotensin

• Lotrel

• Luminal

• Margesic

• Marten-tab

• Mavik

• Maxzide

• Maxzide-25Mg

• Medi-lyte

• Medi-profen

• Mediproxen

• Medrol

• Medrol (pak)

• mefenamic acid

• meloxicam

• methohexital

• methylprednisolone

• methylprednisolone acetate

• methylprednisolone sod suc(PF)

• methylprednisolone sodium succ

• methylprednisolone-bupivacaine

• Micardis

• Micardis Hct

• Midol (naproxen)

• Millipred

• Millipred Dp

• Mobic

• moexipril

• moexipril-hydrochlorothiazide

• Motrin Ib

• Motrin Pm

• Mysoline

• nabumetone

• Nalfon

• Nano Vm T/f

• Naprelan Cr

• Naprosyn

• naproxen

• naproxen sodium

• naproxen-esomeprazole

• naproxen-pseudoephedrine

• Nembutal Sodium

• Neoprofen (ibuprofen Lysn)(pf)

• Nutrilyte Ii

• nystatin-hydrocortisone-diphen

• nystatin-TCN-HC-diphenhydramin

• Octagam

• olmesartan

• olmesartan-amlodipin-hcthiazid

• olmesartan-hydrochlorothiazide

• Orapred

• Orapred Odt

• oxaprozin

• Pedialyte

• Pediapred

• Pediatric Electrolyte

• pediatric multivit #18-iron-FA

• PEG 3350-bowel 2,two part prep

• Peganone

• Pennsaid

• pentobarbital sodium

• perindopril erbumine

• phenobarb-hyoscy-atropine-scop

• phenobarbital

• phenobarbital sodium

• Phenytek

• phenytoin

• phenytoin sodium

• phenytoin sodium extended

• Phos-nak

• Phospha 250 Neutral

• Physicians Ez Use M-pred

• piroxicam

• Ponstel

• pot & sod citrate-citric acid

• potassium

• potassium & sodium phosphates

• potassium bicarb & chloride

• potassium bicarb-citric acid

• potassium chlorid-D5-0.45%NaCl

• potassium chloride

• potassium chloride in 0.9%NaCl

• potassium chloride in D5W

• potassium chloride in LR-D5

• potassium chloride-0.45 % NaCl

• potassium chloride-D5-0.2%NaCl

• potassium chloride-D5-0.3%NaCl

• potassium chloride-D5-0.9%NaCl

• potassium citrate

• potassium citrate-citric acid

• potassium Cl-calcium phos-mag

• potassium gluconate

• potassium phosphate dibasic

• potassium phosphate, monobasic

• potassium&sodium monobas phos

• prednisolone

• prednisolone acetate

• prednisolone sodium phosphate

• prednisone

• Prednisone Intensol

• primidone

• Prinivil

• Privigen

• Proctocort

• Provil

• pseudoephedrine-ibuprofen

• quinapril

• quinapril-hydrochlorothiazide

• raloxifene

• ramipril

• Rayos

• Rectacort-hc

• Reprexain

• secobarbital sodium

• Seconal Sodium

• Sinus & Cold-d

• sod & pot chlorid-sod cit-rice

• sod phos,di & mono-K phos mono

• sodium & potassium bicarbonate

• sodium Cl-potassium chloride

• sodium-K+-mag-Ca-chlor-acetate

• sodium-potas-chloride-dextrose

• Solaraze

• Solu-cortef

• Solu-cortef (pf)

• Solu-medrol

• Solu-medrol (pf)

• Sorbutuss

• spironolacton-hydrochlorothiaz

• spironolactone

• Sprix

• Suclear

• sulindac

• Tarka

• Taron-crystals

• telmisartan

• telmisartan-amlodipine

• telmisartan-hydrochlorothiazid

• Tencon

• Teveten

• Teveten Hct

• Theralith Xr

• Thermotabs

• tolmetin

• Tpn Electrolytes

• Tpn Electrolytes Ii

• trandolapril

• trandolapril-verapamil

• triamcinolone acetonide

• triamcinolone hexacetonide

• triamcinolone-lidocaine

• triamterene

• triamterene-hydrochlorothiazid

• Tribenzor

• Tricitrates

• Twynsta

• Uceris

• Uniretic

• Univasc

• Urocit-k 10

• Urocit-k 15

• Urocit-k 5

• valsartan-hydrochlorothiazide

• Vaseretic

• Vasotec

• Veripred 20

• Vicoprofen

• Vimovo

• vit B6-mag cit & ox-potass cit

• Voltaren-xr

• Wal-profen

• Wal-profen Cold-sinus

• Wal-proxen

• Zebutal

• Zestoretic

• Zestril

• Zipsor

• Zorvolex

Moderate

• Asthma

• Depression

• Edema

• Gallbladder disease

• Hepatic porphyria

• Hypertriglyceridemia

• Hypoparathyroidism

• Hypothyroidism

• Migraine

• Seizure disorder

• Systemic lupus erythematosus

• Unspecified lump in breast

• Uterine leiomyoma

Drospirenone

• Severity Level:

  2

• Additional Notes: Available human data show no increased risk for major birth defects.

Estradiol

• Severity Level:

  2

• Additional Notes: Not indicated during pregnancy; no known dev tox

Contraindicated

None

General	Excretion Potential	Effect on Infant	Notes
			None

Precaution Exists

Drospirenone

None

Limited data indicate higher excretion may occur w/vaginal vs transderm admin

General	Excretion Potential	Effect on Infant	Notes
Evaluate use carefully	Excreted	Not known; no or inclusive data	None

Estradiol

None

Limited data indicate higher excretion may occur w/vaginal vs transderm admin

General	Excretion Potential	Effect on Infant	Notes
Evaluate use carefully	Excreted	Not known; no or inclusive data	Limited data indicate higher excretion may occur w/vaginal vs transderm admin

No Known Risk

None

General	Excretion Potential	Effect on Infant	Notes
			None

Contraindicated

None

Precaution Exists

Estrogenic Agents (systemic)

General-Use lowest possible dose for shortest duration and in combination with a progestin as indicated to reduce the risk of endometrial hyperplasia and breast cancer. Cardiovascular-May increase risk for thromboembolic events. Avoid use in patients with known, suspected, or history of arterial or venous thromboembolic disease. Neuro/Psych-May increase the risk for dementia. Genitourinary-May aggravate urinary incontinence.

Organ / System	HEP	REN	CARD	ENDO	NEURO / PSYCH	PULM
Increased Risk / Adverse Effects	N	N	Y	Y	N	N

BEERS: Y     HEDIS: Y     STOPP: Y

No Known Risk

None

0-9	A-Z
N90.5	Atrophy of vulva
N95.1	Menopausal and female climacteric states
N95.2	Postmenopausal atrophic vaginitis
N95.9	Unspecified menopausal and perimenopausal disorder
Z78.0	Asymptomatic menopausal state