MIDOL COMPLETE (ACETAMINOPHEN/PYRILAMINE MALEATE/CAFFEINE)
Max St Menstrual 500 mg-60 mg-15 mg tablet
- Dosage information is not available
500 mg-60 mg-15 mg tablet
- Dosage information is not available
500 mg-60 mg-15 mg tablet
- Dosage information is not available
- dipyridamole
Contraindicated
- Acid Reducer (cimetidine)
- Acid Relief (cimetidine)
- Adenocard
- Adenoscan
- adenosine
- adenosine (diagnostic)
- cimetidine
- Heartburn Relief
- Lexiscan
- regadenoson
- Tagamet Hb
Severe
Moderate
- Coumadin
- fluvoxamine
- isoniazid
- isoniazid-rifamp-pyrazinamide
- Jantoven
- lithium carbonate
- lithium citrate
- Lithobid
- Luvox Cr
- Rifamate
- rifampin-isoniazid
- Rifater
- warfarin
- 30 day risk period post-myocardial infarction
- Acetaminophen overdose
- Acute hepatic failure
- Acute hepatitis C
Contraindicated
- Angle-closure glaucoma
- Benign prostatic hyperplasia
- Bladder outflow obstruction
- Chronic idiopathic constipation
- Disease of liver
- Necrotizing enterocolitis
- Peptic ulcer
- Protein-calorie malnutrition
- Severe renal impairment
- Shock
- Stenosing peptic ulcer
- Urinary retention
Severe
Moderate
- Cardiac arrhythmia
- Hypertension
- Hyperthyroidism
- Insomnia
- Ocular hypertension
- Renal disease with moderate to severe impairment
- Seizure disorder
- Severe hepatic disease
MIDOL COMPLETE (ACETAMINOPHEN/PYRILAMINE MALEATE/CAFFEINE)
- None
- Abdominal pain with cramps
- Drowsy
- Gastrointestinal irritation
- Insomnia
- Nervousness
- Thick bronchial secretions
More Frequent
Severe
Less Severe
- Abnormal hepatic function tests
- Excitement
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute generalized exanthematous pustulosis
- Acute hepatic failure
- Agranulocytosis
- Allergic dermatitis
- Angioedema
- Blood dyscrasias
- Drug-induced hepatitis
- Extrasystoles
- Laryngeal edema
- Leukopenia
- Maculopapular rash
- Neutropenic disorder
- Stevens-johnson syndrome
- Thrombocytopenic disorder
- Toxic epidermal necrolysis
Less Severe
- Acute confusion
- Agitation
- Anorexia
- Blurred vision
- Dizziness
- Dry nose
- Dry throat
- Dysuria
- Erythema
- Excitement
- Hyperesthesia
- Hyperglycemia
- Hyperhidrosis
- Irritability
- Medication overuse headache
- Nausea
- Nephrotoxicity
- Nervousness
- Nightmares
- Scotomata
- Skin photosensitivity
- Skin rash
- Symptoms of anxiety
- Tachycardia
- Tinnitus
- Tremor
- Urticaria
- Visual changes
- Vomiting
- Xerostomia
Contraindicated
Pyrilamine
Possible CNS excitation and seizure risk in newborns.
Do not use in pediatrics <6 years of age unless clinician consultation.
- 1 Day – 29 Days
- 1 Possible CNS excitation and seizure risk in newborns.
- 1 Do not use in pediatrics <6 years of age unless clinician consultation.
- 30 Days – 6 Years
- 1 Possible CNS excitation and seizure risk in newborns.
- 1 Do not use in pediatrics <6 years of age unless clinician consultation.
Severe Precaution
None
Management or Monitoring Precaution
Acetaminophen (oral,rectal)
Use weight based dosing in children less than 12 years.
Caution in: seizure disorder, cardiovascular disease, or in premature neonates with renal or hepatic impairment.
Adverse CNS effects of insomnia, restlessness, nervousness, and mild delirium, more severe in children.
- 1 Day – 12 Years
- Use weight based dosing in children less than 12 years.
- 1 Day – 364 Days
- Use weight based dosing in children less than 12 years.
- 1 Years – 13 Years
- Use weight based dosing in children less than 12 years.
Caffeine
Use weight based dosing in children less than 12 years.
Caution in: seizure disorder, cardiovascular disease, or in premature neonates with renal or hepatic impairment.
Adverse CNS effects of insomnia, restlessness, nervousness, and mild delirium, more severe in children.
- 1 Day – 12 Years
- Caution in: seizure disorder, cardiovascular disease, or in premature neonates with renal or hepatic impairment.
- Adverse CNS effects of insomnia, restlessness, nervousness, and mild delirium, more severe in children.
- 1 Day – 364 Days
- Caution in: seizure disorder, cardiovascular disease, or in premature neonates with renal or hepatic impairment.
- Adverse CNS effects of insomnia, restlessness, nervousness, and mild delirium, more severe in children.
- 1 Years – 13 Years
- Caution in: seizure disorder, cardiovascular disease, or in premature neonates with renal or hepatic impairment.
- Adverse CNS effects of insomnia, restlessness, nervousness, and mild delirium, more severe in children.
Acetaminophen
- Severity Level:
2
- Additional Notes: Available data suggest no known risk; otc product, no fda pregnancy warnings
Caffeine
- Severity Level:
C
- Additional Notes: Reports of miscarriage,poor fetal growth possibly assoc w/high doses of caffeine
Pyrilamine
- Severity Level:
2
- Additional Notes: No fda category; incr risk of retrolental fibroplasia seen in premature infants
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Caffeine
High doses may cause hyperactivity and wakefulness in infant.
Use is not recommended; may cause unusual excitement or irritability
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Drug shown to have adverse effect | High doses may cause hyperactivity and wakefulness in infant. |
Pyrilamine
High doses may cause hyperactivity and wakefulness in infant.
Use is not recommended; may cause unusual excitement or irritability
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Drug shown to have adverse effect | Use is not recommended; may cause unusual excitement or irritability |
No Known Risk
Acetaminophen
Low levels excreted with low risk for adverse effects in infant
General | Excretion Potential | Effect on Infant | Notes |
No known risks; does not adversely affect lactation | Excreted | No adverse effect | Low levels excreted with low risk for adverse effects in infant |
Contraindicated
None
Precaution Exists
Acetaminophen (oral,rectal)
Hepatic-Elderly may be more susceptible to hepatotoxicity. Strict adherence to a maximum daily dose is recommended, and the maximum dose recommendation varies between 3000-3800 mg depending on strength used and source of the recommendation.
Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Non-sedating antihistamine preferred. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | N | Y | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
Pyrilamine
Hepatic-Elderly may be more susceptible to hepatotoxicity. Strict adherence to a maximum daily dose is recommended, and the maximum dose recommendation varies between 3000-3800 mg depending on strength used and source of the recommendation.
Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Non-sedating antihistamine preferred. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | N | N | N | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- None