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NEXICLON XR (clonidine HCl)
- high blood pressure
0.17 mg tablet,extended release
- 1 tablet (0.17 mg) by oral route once daily
0.17 mg tablet,extended release
- 1 tablet (0.17 mg) by oral route once daily
Default screening record
- 1 tablet (0.17 mg) by oral route once daily
- 1 tablet (0.17 mg) by oral route once daily may increase by increments of 0.09 mg at weekly intervals until desired response, not to exceed 0.52 mg
- 2 tablets (0.34 mg) by oral route once daily
- None
Contraindicated
- acebutolol
- atenolol
- atenolol-chlorthalidone
- Betagan
- Betapace
- Betapace Af
- betaxolol
- Betimol
- Betoptic S
- bisoprolol fumarate
- bisoprolol-hydrochlorothiazide
- Brevibloc
- Brevibloc In Nacl (iso-osm)
- brimonidine-timolol
- Bystolic
- carteolol
- carvedilol
- carvedilol phosphate
- Combigan
- Coreg
- Coreg Cr
- Corgard
- Corzide
- Cosopt
- Cosopt Pf
- dorzolamide-timolol
- dorzolamide-timolol (PF)
- Dutoprol
- esmolol
- esmolol in NaCl (iso-osm)
- Inderal La
- Inderal Xl
- Innopran Xl
- Istalol
- labetalol
- Levatol
- levobunolol
- Lopressor
- Lopressor Hct
- metipranolol
- metoprolol su-hydrochlorothiaz
- metoprolol succinate
- metoprolol ta-hydrochlorothiaz
- metoprolol tartrate
- nadolol
- nadolol-bendroflumethiazide
- nebivolol
- penbutolol
- pindolol
- propranolol
- propranolol-hydrochlorothiazid
- Sectral
- Sorine
- sotalol
- Sotalol Af
- Tenoretic 100
- Tenoretic 50
- Tenormin
- timolol
- timolol maleate
- timolol maleate (PF)
- Timoptic
- Timoptic Ocudose (pf)
- Timoptic-xe
- Toprol Xl
- Trandate
- Zebeta
- Ziac
Severe
Moderate
- amitriptyline
- amitriptyline-chlordiazepoxide
- amoxapine
- Amrix
- Anafranil
- clomipramine
- cyclobenzaprine
- cyclobenzaprine with msm
- desipramine
- doxepin
- imipramine HCl
- imipramine pamoate
- mirtazapine
- Norpramin
- nortriptyline
- Pamelor
- perphenazine-amitriptyline
- protriptyline
- Prudoxin
- Remeron
- Remeron Soltab
- Silenor
- Surmontil
- Tabradol
- Tofranil
- Tofranil-pm
- trimipramine
- Vivactil
- Zonalon
- None
Contraindicated
- Atrioventricular block
- Depression
- Invasive surgical procedure
- Raynaud's phenomenon
- Sinus bradycardia
Severe
Moderate
- Acute myocardial infarction
- Cerebrovascular disorder
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Chronic myocardial ischemia
- Dry eye
NEXICLON XR (clonidine HCl)
- high blood pressure
- None
- Constipation
- Dizziness
- Drowsy
- Fatigue
- General weakness
- Irritability
- Xerostomia
More Frequent
Severe
Less Severe
- Depression
- Abnormal sexual function
- Anorexia
- Dry eye
- Earache
- Erectile dysfunction
- Nasal congestion
- Nausea
- Nervousness
- Ocular irritation
- Ocular itching
- Orthostatic hypotension
- Sore throat
- Upper abdominal pain
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal ECG
- Angioedema
- Atrioventricular block
- Bradycardia
- Chronic heart failure
- Hepatitis
- Hypotension
- Nightmares
- Raynaud's phenomenon
- Syncope
Less Severe
- Accommodation disorder
- Agitation
- Blurred vision
- Cramps in legs
- Delirium
- Delusional disorder
- Dry nose
- Fever
- Gynecomastia
- Hallucinations
- Headache disorder
- Insomnia
- Myalgia
- Nocturia
- Pallor
- Paresthesia
- Sleep disorder
- Symptoms of anxiety
- Urinary retention
- Weight gain
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
None
Clonidine
- Severity Level:
2
- Additional Notes: Insufficient human data available on developmental toxicity risk.
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Clonidine
Potential adverse effects to infant.
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Potential adverse effects to infant. |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Clonidine
Cardiovascular-Risk for orthostatic hypotension, falls. Caution with conduction abnormalities. Neuro/Psych-Risk of somnolence, fatigue.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | Y | N | N |
BEERS: Y HEDIS: N STOPP: Y
No Known Risk
None
- None
| Hypertension | |
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
| 0-9 | A-Z |
|---|---|
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
Formulary Reference Tool