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CRINONE (progesterone, micronized)
- Amenorrhea secondary to ovarian dysfunction
- Amenorrhea secondary to ovarian dysfunction
- Infertility secondary to progesterone deficiency
4 % vaginal gel
- Insert 1 applicatorful (90 mg) by vaginal route every other day up toa total of six doses
8 % vaginal gel
- Insert 1 applicatorful (90 mg) by vaginal route once daily
Amenorrhea secondary to ovarian dysfunction
- Insert 1 applicatorful (90 mg) by vaginal route every other day up toa total of six doses
Infertility secondary to progesterone deficiency
- Insert 1 applicatorful (90 mg) by vaginal route once daily
- Insert 1 applicatorful (90 mg) by vaginal route 2 times per day
- None
Contraindicated
- None
Severe
Moderate
- None
- Carcinoma of breast
- Cerebrovascular accident
- Disease of liver
- Malignant neoplasm of liver
- Porphyria
- Predisposition to thrombosis
- Pulmonary thromboembolism
- Thromboembolic disorder
- Thrombophlebitis
Contraindicated
- Hypertension
Severe
Moderate
- Asthma
- Chronic heart failure
- Depression
- Diabetes mellitus
- Hyperlipidemia
- Kidney disease with reduction in GFR
- Migraine
- Seizure disorder
CRINONE (progesterone, micronized)
- Amenorrhea secondary to ovarian dysfunction
- Amenorrhea secondary to ovarian dysfunction
- Infertility secondary to progesterone deficiency
- Abdominal distension
- Abnormal vaginal bleeding
- Irregular menstrual periods
- Appetite changes
- Edema
- Fatigue
- Headache disorder
- Myalgias
- Vaginitis
- Weight loss
More Frequent
Severe
Less Severe
- None
- Dizziness
- Dyspepsia
- Hypertonia
- Irritability
- Vaginal discharge
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Anaphylaxis
- Angioedema
- Back pain
- Chest pain
- Cystitis
- Depression
- Ectopic pregnancy
- Erythema multiforme
- Erythema nodosum
- Galactorrhea not associated with childbirth
- Hepatitis
- Hypersensitivity drug reaction
- Malignant neoplasm of the ovary
- Menorrhagia
- Obstructive hyperbilirubinemia
- Optic neuritis
- Ovarian cyst
- Pancreatitis
- Pruritus of skin
- Pulmonary thromboembolism
- Retinal thrombosis
- Skin rash
- Thromboembolic disorder
- Thrombophlebitis
Less Severe
- Acne vulgaris
- Alopecia
- Amenorrhea
- Body fluid retention
- Cervical discharge
- Chloasma
- Constipation
- Drowsy
- Erosion of cervix
- Fever
- Hirsutism
- Hyperglycemia
- Insomnia
- Limb pain
- Mastalgia
- Migraine
- Nausea
- Nervousness
- Urticaria
- Weight gain
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Progesterone
Safety and efficacy in pediatrics have not been established.
- 1 Day – 18 Years
- Safety and efficacy in pediatrics have not been established.
Progesterone
- Severity Level:
B
- Additional Notes: Insufficient human data; animal data do not suggest dev tox
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
Progesterone
Data suggest low amount excreted with no adverse effects on infants
| General | Excretion Potential | Effect on Infant | Notes |
| No known risks; does not adversely affect lactation | Excreted | Not known; no or inclusive data | Data suggest low amount excreted with no adverse effects on infants |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Amenorrhea secondary to ovarian dysfunction | |
| E28.8 | Other ovarian dysfunction |
| E28.9 | Ovarian dysfunction, unspecified |
| N91.0 | Primary amenorrhea |
| N91.1 | Secondary amenorrhea |
| N91.2 | Amenorrhea, unspecified |
| Infertility secondary to progesterone deficiency | |
| N97.8 | Female infertility of other origin |
| 0-9 | A-Z |
|---|---|
| E28.8 | Other ovarian dysfunction |
| E28.9 | Ovarian dysfunction, unspecified |
| N91.0 | Primary amenorrhea |
| N91.1 | Secondary amenorrhea |
| N91.2 | Amenorrhea, unspecified |
| N97.8 | Female infertility of other origin |
Formulary Reference Tool