Aprodine (pseudoephedrine hcl/triprolidine hcl) — MAJOR PHARMACEU

Allergic rhinitis
Cold symptoms
Nasal congestion
Allergic conjunctivitis
Atopic rhinitis
Rhinorrhea
Seasonal allergic rhinitis
Sneezing
Vasomotor rhinitis
2.5 mg-60 mg tablet
1 tablet by oral route every 4-6 hours as needed

2.5 mg-60 mg tablet
1 tablet by oral route every 4-6 hours as needed

4 mg-10 mg tablet
Dosage information is not available

2.5 mg-60 mg tablet
1 tablet by oral route every 4-6 hours as needed

4 mg-10 mg tablet
Dosage information is not available

2.5 mg-60 mg tablet
1 tablet by oral route every 4-6 hours as needed

2.5 mg-60 mg tablet
1 tablet by oral route every 4-6 hours as needed

2.5 mg-60 mg tablet
1 tablet by oral route every 4-6 hours as needed

2.5 mg-60 mg tablet
1 tablet by oral route every 4-6 hours as needed

Nasal congestion
Dosage Type: Tablet
1 tablet by oral route every 4 hours as needed
1 tablet by oral route every 4-6 hours as needed
1 tablet by oral route every 6 hours as needed

Rhinorrhea
1 tablet by oral route every 4 hours as needed
1 tablet by oral route every 4-6 hours as needed
1 tablet by oral route every 6 hours as needed

Sneezing
1 tablet by oral route every 4 hours as needed
1 tablet by oral route every 4-6 hours as needed
1 tablet by oral route every 6 hours as needed
Severe Warnings
Benign prostatic hypertrophy
Bladder outflow obstruction
Chronic idiopathic constipation
Diabetes mellitus
Hypertension
Hyperthyroidism
Narrow angle glaucoma
Stenosing peptic ulcer
Urinary retention
Contraindicated
Narrow angle glaucoma
Severe coronary artery disease
Severe uncontrolled hypertension
Urinary retention
Moderate Warnings
Hypertension
Hyperthyroidism
Ocular hypertension
Less Frequent
Severe
None

Less Severe
Anorexia
Dizziness
Drowsy
Dysuria
Feeling agitated
General weakness
Nausea
Nervousness
Pallor
Tachyarrhythmia
Tremors
More Frequent
Severe
None

Less Severe
Drowsy
Headache disorder
Insomnia
Thick bronchial secretions
Rare / Very Rare
Severe
Allergic reactions
Blood dyscrasias
Dyspnea
Extrasystoles
Hallucinations
Hypertension
Ischemic colitis
Seizure disorder
Tonic clonic seizure
Vomiting

Less Severe
Abdominal pain with cramps
Anorexia
Anxiety
Blurred vision
Conduction disorder of the heart
Dizziness
Dry nose
Dry throat
Dyspepsia
Dysuria
Excitement
Headache disorder
Hyperhidrosis
Impaired cognition
Nervousness
Nightmares
Palpitations
Pruritus of skin
Skin photosensitivity
Skin rash
Tachyarrhythmia
Tinnitus
Tremors
Urticaria
Visual changes
Xerostomia
More information
Contraindicated
Pseudoephedrine (Immed.Rel.Solid)
1 Day – 6 Years
High risk of adverse CNS effects. Not recommended for use age < 6 years.
Triprolidine
1 Day – 119 Days
Use not recommended age <4 months. CNS excitation and seizure risk in newborns.
Triprolidine
120 Days – 6 Years
Do not use in pediatrics <6 years of age unless clinician consultation.

Severe Precaution
None

Management or Monitoring Precaution
None
Pseudoephedrine
Severity Level: C
Additional Notes: Fda c w/combo prod; poss risk of gastroschisis/sia with 1st trimester exposure

Triprolidine
Severity Level: C
Additional Notes: Fda category c in combination product

More information
Contraindicated
None

Precaution Exists
Pseudoephedrine
GeneralExcretion PotentialEffect on InfantNotes
Evaluate use carefullyExcretedDrug shown to have adverse effectMay decrease milk supply, and cause irritability
Triprolidine
GeneralExcretion PotentialEffect on InfantNotes
Evaluate use carefullyExcretedNot known; no or inclusive dataInsuf data; other antihistamines may cause irritability, drowsiness in infant

No Known Risk
None
More information
Contraindicated
None

Precaution Exists
Pseudoephedrine
Cardiovascular-Elderly are more sensitive to tachycardia and hypertensive effects. May exacerbate symptomatic coronary insufficiency. Genitourinary-May cause urinary retention. Neuro/Psych-May worsen cognitive impairment in some elderly with dementia. Insomnia risk.
Organ / SystemHEPRENCARDENDONEURO / PSYCHPULM
Increased Risk / Adverse EffectsNYYNYN
BEERS: Y   HEDIS: Y   STOPP: N

Triprolidine
Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Non-sedating antihistamine preferred. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
Organ / SystemHEPRENCARDENDONEURO / PSYCHPULM
Increased Risk / Adverse EffectsNNNNYN
BEERS: Y   HEDIS: Y   STOPP: Y

No Known Risk
None
Allergic conjunctivitis
372.14Chronic allergic conjunctivitis not elsewhere classified
372.3Conjunctivitis not elsewhere classified and not otherwise specified
372.30Conjunctivitis not otherwise specified
372.39Conjunctivitis not elsewhere classified
Allergic rhinitis
477Allergic rhinitis
477.0Rhinitis due to pollen
477.1Allergic rhinitis due to food
477.2Allergic rhinitis due to animal (cat, dog) hair and dander
477.8Allergic rhinitis not elsewhere classified
477.9Allergic rhinitis not otherwise specified
Atopic rhinitis
477.9Allergic rhinitis not otherwise specified
Cold symptoms
460Acute nasopharyngitis
Nasal congestion
478.1Other diseases of nasal cavity and sinuses
478.19Other disease of nasal cavity and sinuses
Rhinorrhea
478.1Other diseases of nasal cavity and sinuses
478.19Other disease of nasal cavity and sinuses
Seasonal allergic rhinitis
477.9Allergic rhinitis not otherwise specified
Sneezing
784.9Other symptom involving head and neck
784.99Other symptoms involving head and neck
Vasomotor rhinitis
477.9Allergic rhinitis not otherwise specified
0-9 A-Z
372.14 Chronic allergic conjunctivitis not elsewhere classified
372.3 Conjunctivitis not elsewhere classified and not otherwise specified
372.30 Conjunctivitis not otherwise specified
372.39 Conjunctivitis not elsewhere classified
460 Acute nasopharyngitis
477 Allergic rhinitis
477.0 Rhinitis due to pollen
477.1 Allergic rhinitis due to food
477.2 Allergic rhinitis due to animal (cat, dog) hair and dander
477.8 Allergic rhinitis not elsewhere classified
477.9 Allergic rhinitis not otherwise specified
477.9 Allergic rhinitis not otherwise specified
477.9 Allergic rhinitis not otherwise specified
477.9 Allergic rhinitis not otherwise specified
478.1 Other diseases of nasal cavity and sinuses
478.1 Other diseases of nasal cavity and sinuses
478.19 Other disease of nasal cavity and sinuses
478.19 Other disease of nasal cavity and sinuses
784.9 Other symptom involving head and neck
784.99 Other symptoms involving head and neck

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Diagnosis codes are provided for reference only. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatement.