Aprodine (pseudoephedrine hcl/triprolidine hcl) — MAJOR PHARMACEU

Allergic rhinitis
Cold symptoms
Nasal congestion
Allergic conjunctivitis
Perennial allergic rhinitis
Rhinorrhea
Seasonal allergic rhinitis
Sneezing
Vasomotor rhinitis
2.5 mg-60 mg tablet
1 tablet by oral route every 4-6 hours as needed

Cold and Allergy 4 mg-10 mg tablet
Dosage information is not available

Cold and Allergy 4 mg-10 mg tablet
Dosage information is not available

Cold and Allergy (triprolidine) 2.5 mg-60 mg tablet
1 tablet by oral route every 4-6 hours as needed

2.5 mg-60 mg tablet
1 tablet by oral route every 4-6 hours as needed

Nasal Decongestant-Antihist 2.5 mg-60 mg tablet
1 tablet by oral route every 4-6 hours as needed

Nasal Decongest-Antihistamine 2.5 mg-60 mg tablet
1 tablet by oral route every 4-6 hours as needed

Wal-Act D Cold and Allergy 2.5 mg-60 mg tablet
1 tablet by oral route every 4-6 hours as needed

Nasal congestion
Dosage Type: Tablet
1 tablet by oral route every 4 hours as needed
1 tablet by oral route every 4-6 hours as needed
1 tablet by oral route every 6 hours as needed

Rhinorrhea
1 tablet by oral route every 4 hours as needed
1 tablet by oral route every 4-6 hours as needed
1 tablet by oral route every 6 hours as needed

Sneezing
1 tablet by oral route every 4 hours as needed
1 tablet by oral route every 4-6 hours as needed
1 tablet by oral route every 6 hours as needed
Severe Warnings
Benign prostatic hyperplasia
Bladder outflow obstruction
Chronic idiopathic constipation
Diabetes mellitus
Hypertension
Hyperthyroidism
Narrow angle glaucoma
Stenosing peptic ulcer
Urinary retention
Contraindicated
Narrow angle glaucoma
Severe coronary artery disease
Severe uncontrolled hypertension
Urinary retention
Moderate Warnings
Hypertension
Hyperthyroidism
Ocular hypertension
Less Frequent
Severe
None

Less Severe
Anorexia
Dizziness
Drowsy
Dysuria
Feeling agitated
General weakness
Nausea
Nervousness
Pallor
Tachyarrhythmia
Tremors
More Frequent
Severe
None

Less Severe
Drowsy
Headache disorder
Insomnia
Thick bronchial secretions
Rare / Very Rare
Severe
Blood dyscrasias
Dyspnea
Extrasystoles
Hallucinations
Hypertension
Ischemic colitis
Seizure disorder
Vomiting

Less Severe
Abdominal pain with cramps
Anorexia
Anxiety
Blurred vision
Conduction disorder of the heart
Diarrhea
Dizziness
Dry nose
Dry throat
Dyspepsia
Dysuria
Excitement
Headache disorder
Hyperhidrosis
Impaired cognition
Insomnia
Irritability
Nervousness
Nightmares
Palpitations
Pruritus of skin
Skin photosensitivity
Skin rash
Tachyarrhythmia
Tinnitus
Tremors
Urinary retention
Urticaria
Vertigo
Visual changes
Xerostomia
More information
Contraindicated
Pseudoephedrine (Immed. Release)
1 Day – 6 Years
High risk of adverse CNS effects. Not recommended for use age < 6 years.
Triprolidine
1 Day – 119 Days
Use not recommended age <4 months. CNS excitation and seizure risk in newborns.
Triprolidine
120 Days – 6 Years
Do not use in pediatrics <6 years of age unless clinician consultation.

Severe Precaution
None

Management or Monitoring Precaution
None
Pseudoephedrine
Severity Level: C
Additional Notes: Fda c w/combo prod; poss risk of gastroschisis/sia with 1st trimester exposure

Triprolidine
Severity Level: C
Additional Notes: Fda category c in combination product

More information
Contraindicated
None

Precaution Exists
Pseudoephedrine
GeneralExcretion PotentialEffect on InfantNotes
Evaluate use carefullyExcretedDrug shown to have adverse effectMay decrease milk supply, and cause irritability
Triprolidine
GeneralExcretion PotentialEffect on InfantNotes
Evaluate use carefullyExcretedNot known; no or inclusive dataInsuf data; other antihistamines may cause irritability, drowsiness in infant

No Known Risk
None
More information
Contraindicated
None

Precaution Exists
Pseudoephedrine
Cardiovascular-Elderly are more sensitive to tachycardia and hypertensive effects. May exacerbate symptomatic coronary insufficiency. Genitourinary-May cause urinary retention. Neuro/Psych-May worsen cognitive impairment in some elderly with dementia. Insomnia risk.
Organ / SystemHEPRENCARDENDONEURO / PSYCHPULM
Increased Risk / Adverse EffectsNYYNYN
BEERS: Y   HEDIS: Y   STOPP: N

Triprolidine
Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Non-sedating antihistamine preferred. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
Organ / SystemHEPRENCARDENDONEURO / PSYCHPULM
Increased Risk / Adverse EffectsNNNNYN
BEERS: Y   HEDIS: Y   STOPP: Y

No Known Risk
None
Allergic conjunctivitis
H10.1Acute atopic conjunctivitis
H10.10Acute atopic conjunctivitis, unspecified eye
H10.11Acute atopic conjunctivitis, right eye
H10.12Acute atopic conjunctivitis, left eye
H10.13Acute atopic conjunctivitis, bilateral
H10.44Vernal conjunctivitis
H10.45Other chronic allergic conjunctivitis
H16.26Vernal keratoconjunctivitis, with limbar and corneal involvement
H16.261Vernal keratoconjunctivitis, with limbar and corneal involvement, right eye
H16.262Vernal keratoconjunctivitis, with limbar and corneal involvement, left eye
H16.263Vernal keratoconjunctivitis, with limbar and corneal involvement, bilateral
H16.269Vernal keratoconjunctivitis, with limbar and corneal involvement, unspecified eye
Allergic rhinitis
J30Vasomotor and allergic rhinitis
J30.0Vasomotor rhinitis
J30.1Allergic rhinitis due to pollen
J30.2Other seasonal allergic rhinitis
J30.5Allergic rhinitis due to food
J30.8Other allergic rhinitis
J30.81Allergic rhinitis due to animal (cat) (dog) hair and dander
J30.89Other allergic rhinitis
J30.9Allergic rhinitis, unspecified
J31.0Chronic rhinitis
Nasal congestion
R09.81Nasal congestion
Rhinorrhea
J31.0Chronic rhinitis
R09.82Postnasal drip
Seasonal allergic rhinitis
J30.1Allergic rhinitis due to pollen
J30.2Other seasonal allergic rhinitis
0-9 A-Z
H10.1 Acute atopic conjunctivitis
H10.10 Acute atopic conjunctivitis, unspecified eye
H10.11 Acute atopic conjunctivitis, right eye
H10.12 Acute atopic conjunctivitis, left eye
H10.13 Acute atopic conjunctivitis, bilateral
H10.44 Vernal conjunctivitis
H10.45 Other chronic allergic conjunctivitis
H16.26 Vernal keratoconjunctivitis, with limbar and corneal involvement
H16.261 Vernal keratoconjunctivitis, with limbar and corneal involvement, right eye
H16.262 Vernal keratoconjunctivitis, with limbar and corneal involvement, left eye
H16.263 Vernal keratoconjunctivitis, with limbar and corneal involvement, bilateral
H16.269 Vernal keratoconjunctivitis, with limbar and corneal involvement, unspecified eye
J30 Vasomotor and allergic rhinitis
J30.0 Vasomotor rhinitis
J30.1 Allergic rhinitis due to pollen
J30.1 Allergic rhinitis due to pollen
J30.2 Other seasonal allergic rhinitis
J30.2 Other seasonal allergic rhinitis
J30.5 Allergic rhinitis due to food
J30.8 Other allergic rhinitis
J30.81 Allergic rhinitis due to animal (cat) (dog) hair and dander
J30.89 Other allergic rhinitis
J30.9 Allergic rhinitis, unspecified
J31.0 Chronic rhinitis
J31.0 Chronic rhinitis
R09.81 Nasal congestion
R09.82 Postnasal drip

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Diagnosis codes are provided for reference only. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatement.