Symbicort (budesonide/formoterol fumarate) — ASTRAZENECA

Maintenance therapy for asthma
Bronchospasm prevention with COPD
Maintenance therapy for asthma
Prevention of bronchospasm with chronic bronchitis
Prevention of bronchospasms with emphysema
160 mcg-4.5 mcg/actuation HFA aerosol inhaler
Inhale 2 puffs by inhalation route 2 times per day in the morning andevening

80 mcg-4.5 mcg/actuation HFA aerosol inhaler
Inhale 2 puffs by inhalation route 2 times per day in the morning andevening

Maintenance therapy for asthma
Dosage Type: Hfa aerosol with adapter (gram)
Inhale 2 puffs by inhalation route 2 times per day in the morning andevening
Inhale 2 puffs by inhalation route 2 times per day in the morning andevening

Prevention of bronchospasms with emphysema
Inhale 2 puffs by inhalation route 2 times per day in the morning andevening
Moderate
Ablavar
Advair Diskus
Advair Hfa
alfuzosin
amantadine HCl
amoxicil-clarithromy-lansopraz
Anzemet
arsenic trioxide
asenapine
Astagraf Xl
Avelox
Avelox Abc Pack
Avelox In Nacl (iso-osmotic)
azithromycin
bedaquiline
Betapace
Betapace Af
Biaxin
Biaxin Xl
Biaxin Xl Pak
Caprelsa
Cardene Iv
Cardene Iv In Dextrose
Cardene Iv In Sodium Chloride
Cardene Sr
Celexa
chloroquine phosphate
chlorpromazine
Cipro
Cipro In D5W
Cipro Xr
ciprofloxacin
ciprofloxacin (mixture)
ciprofloxacin in D5W
citalopram
clarithromycin
clozapine
Clozaril
Complera
Corvert
crizotinib
dasatinib
Diflucan
Diskets
dofetilide
dolasetron
Dolophine
Edurant
Effexor Xr
emtricitab-rilpivirine-tenofov
Eovist
eribulin
Erythrocin
erythromycin
erythromycin-sulfisoxazole
escitalopram oxalate
ezogabine
Fareston
Fazaclo
felbamate
Felbatol
flecainide
fluconazole
fluconazole in dextrose(iso-o)
fluconazole in NaCl (iso-osm)
fluticasone-salmeterol
foscarnet
Foscavir
gadofosveset trisodium
gadoxetate
granisetron
granisetron (PF)
Granisol
Halaven
Haldol
Haldol Decanoate
haloperidol
haloperidol decanoate
haloperidol lactate
Hecoria
ibutilide fumarate
indapamide
Invega
Invega Sustenna
Invirase
isradipine
Istodax
itraconazole
Ketek
ketoconazole
lapatinib
Levaquin
Levaquin In 5 % Dextrose
Levitra
levofloxacin
levofloxacin in D5W
Lexapro
lithium carbonate
lithium citrate
Lithobid
methadone
Methadone Intensol
Methadose
moexipril
moexipril-hydrochlorothiazide
moxifloxacin
moxifloxacin in NaCl (iso-osm)
Nebupent
Nexavar
nicardipine
nicardipine in dextrose,iso-os
nicardipine in NaCl (iso-os)
nilotinib
norfloxacin
Noroxin
Noxafil
octreotide acetate
ofloxacin
Omeclamox-pak
omeprazole-clarith-amoxicillin
ondansetron
ondansetron HCl
ondansetron HCl (PF)
Onmel
paliperidone
paliperidone palmitate
pasireotide
pazopanib
Pentam
pentamidine
posaconazole
Potiga
Prevpac
procainamide
Prograf
Qualaquin
quetiapine
quinine sulfate
rilpivirine
Risperdal
Risperdal Consta
Risperdal M-tab
risperidone
risperidone microspheres
romidepsin
salmeterol
Sancuso
Sandostatin
Sandostatin Lar Depot
Saphris
Saphris (black Cherry)
saquinavir mesylate
Serevent Diskus
Seroquel
Seroquel Xr
Signifor
Sirturo
Soltamox
sorafenib
Sorine
sotalol
Sotalol Af
Sporanox
Sporanox Pulsepak
Sprycel
sunitinib
Sutent
tacrolimus
tamoxifen
Tasigna
telavancin
telithromycin
tetrabenazine
Tikosyn
tizanidine
toremifene
Trisenox
Tykerb
Uniretic
Univasc
Uroxatral
vandetanib
vardenafil
vemurafenib
venlafaxine
Versacloz
Vfend
Vfend Iv
Vibativ
voriconazole
Votrient
Xalkori
Xenazine
Zanaflex
Zelboraf
Zithromax
Zithromax Tri-pak
Zithromax Z-pak
Zmax
Zofran
Zofran Odt
Zuplenz
Severe Warnings
Congenital long QT syndrome
Herpes simplex infection
Hypokalemia
Inactive tuberculosis
Ocular herpes simplex
Ocular hypertension
Parasitic infection
Prolonged QT interval
Pulmonary tuberculosis
Varicella contact
Varicella zoster virus infection
Contraindicated
Acutely deteriorating asthma
Moderate Warnings
Brain aneurysm
Cardiac arrhythmia
Cataracts
Chronic myocardial ischemia
Diabetes mellitus
Glaucoma
Hypercortisolism
Hypertension
Oropharyngeal candidiasis
Osteopenia
Osteoporosis
Pheochromocytoma
Seizure disorder
Thyrotoxicosis
Less Frequent
Severe
Chest pain
Pharyngitis
Sinusitis
Tremors

Less Severe
Abdominal pain with cramps
Acute bacterial otitis media
Bronchitis
Bruising
Cramps
Diarrhea
Dizziness
Dysgeusia
Dyspnea
Ecchymosis
Fainting
Fever
Gastroenteritis
General weakness
Headache disorder
Insomnia
Nausea
Pain
Pharyngitis
Rhinitis
Skin rash
Upper respiratory infection
Viral infection
Voice change
Vomiting
Xerostomia
More Frequent
Severe
None

Less Severe
Cough
Dyspepsia
Headache disorder
Nasal congestion
Oral candidiasis
Sinusitis
Sore throat
Voice change
Rare / Very Rare
Severe
Anaphylaxis
Angina
Angioedema
Asthma exacerbation
Atrial fibrillation
Cardiac arrhythmia
Cataracts
Drug-induced psychosis
Eosinophilic granulomatosis with polyangiitis
Gastroenteritis
Glaucoma
Hypercortisolism
Hyperglycemia
Hypertension
Hypokalemia
Hypotension
Immunosuppression
Malaise
Metabolic acidosis
Ocular hypertension
Osteopenia
Paradoxical bronchospasm
Prolonged QT interval
Tachyarrhythmia
Tonsillitis
Urticaria
Ventricular premature beats

Less Severe
Abdominal pain with cramps
Aggressive behavior
Arthralgia
Contact dermatitis
Cough
Depression
Dyspepsia
Esophageal candidiasis
Fatigue
Fever
Flu-like symptoms
Increased sputum
Irritability
Nervousness
Palpitations
Pruritus of skin
Rhinitis
Skin rash
Symptoms of anxiety
Urticaria
More information
Contraindicated
None

Severe Precaution
Budesonide_Formoterol (low dose)
1 Day – 6 Years
Risk of decreased growth rate. Safety and efficacy not established age<6 years.
Glucocorticoid_LA-Beta Agonist
1 Day – 12 Years
Safety and efficacy not established age<12 years. Do not use for acute asthma. Risk of decreased growth rate.

Management or Monitoring Precaution
Budesonide (Aerosol Pwder_Misc)
6 Years – 18 Years
May reduce growth rate; monitor growth and use lowest effective dose.
Glucocorticoid_Formoterol
12 Years – 18 Years
May reduce growth velocity, monitor growth rate. Not for acute asthma event. Titrate to lowest effective dose.
Budesonide (inhal, Nasal)
Severity Level: B
Additional Notes: Current evidence supports use of inhaled corticosteroids for asthma tx in preg

Formoterol Fumarate
Severity Level: 2
Additional Notes: Insufficient human data available

More information
Contraindicated
None

Precaution Exists
Budesonide
GeneralExcretion PotentialEffect on InfantNotes
Evaluate use carefullyExcretedNot known; no or inclusive dataReported amount in breastmilk < 1% of maternal dose w/ inhalation.
Formoterol
GeneralExcretion PotentialEffect on InfantNotes
Evaluate use carefullyUnknownNot known; no or inclusive dataExcret in rat studies;Low plasma levels,amt excret unlikely to be clin signif

No Known Risk
None
More information
Contraindicated
None

Precaution Exists
Formoterol
Cardiovascular-Use caution in severe cardiovascular diseases (e.g. coronary insufficiency, aneurysm) since beta-agonists increase heart rate and blood pressure. Endocrine-Use caution in poorly controlled hyperthyroidism or diabetes.
Organ / SystemHEPRENCARDENDONEURO / PSYCHPULM
Increased Risk / Adverse EffectsNNYYNN
BEERS: N   HEDIS: N   STOPP: N

No Known Risk
None
Bronchospasm prevention with COPD
J44Other chronic obstructive pulmonary disease
J44.9Chronic obstructive pulmonary disease, unspecified
Prevention of bronchospasm with chronic bronchitis
J44Other chronic obstructive pulmonary disease
J44.9Chronic obstructive pulmonary disease, unspecified
J44 Other chronic obstructive pulmonary disease
J44 Other chronic obstructive pulmonary disease
J44.9 Chronic obstructive pulmonary disease, unspecified
J44.9 Chronic obstructive pulmonary disease, unspecified

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Diagnosis codes are provided for reference only. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatement.