Simbrinza (brinzolamide/brimonidine tartrate) — ALCON LABS.

Open angle glaucoma
Ocular hypertension
1 %-0.2 % eye drops,suspension
Instill 1 drop into affected eye(s) by ophthalmic route 3 times per day

Ocular hypertension
Dosage Type: Suspension, drops(final dosage form)(ml)
Instill 1 drop into both eyes by ophthalmic route 3 times per day
Instill 1 drop into left eye by ophthalmic route 3 times per day
Instill 1 drop into right eye by ophthalmic route 3 times per day
Instill 1 drop into affected eye(s) by ophthalmic route 3 times per day

Open angle glaucoma
Instill 1 drop into both eyes by ophthalmic route 3 times per day
Instill 1 drop into left eye by ophthalmic route 3 times per day
Instill 1 drop into right eye by ophthalmic route 3 times per day
Instill 1 drop into affected eye(s) by ophthalmic route 3 times per day
Severe Warnings
Severe cardiovascular disease
Severe renal disease
Contraindicated
None
Moderate Warnings
Buerger's disease
Cerebrovascular disorder
Depression
Orthostatic hypotension
Raynaud's phenomenon
Less Frequent
Severe
Allergic dermatitis
Blepharitis
Blurred vision
Chemosis
Conjunctival hemorrhage
Corneal erosion
Depression
Dizziness
Erythema
Eyelid edema
Fainting
Gastrointestinal irritation
Headache disorder
Hypertension
Keratitis
Mucopurulent conjunctivitis
Myalgia
Nasal congestion
Nausea
Ocular discharge
Ocular discomfort
Ocular pain
Rhinitis
Sneezing
Visual changes
Vomiting

Less Severe
Anxiety
Conjunctival blanching
Corneal staining
Dry eye
Dysgeusia
Insomnia
Muscle weakness
Ocular crusting
Ocular discomfort
Palpitations
Photophobia
Rhinitis
More Frequent
Severe
Conjunctival hyperemia
Follicular conjunctivitis
Headache disorder
Ocular itching
Ocular redness

Less Severe
Allergic conjunctivitis
Blurred vision
Drowsy
Dysgeusia
Eye tearing
Fatigue
Ocular irritation
Xerostomia
Rare / Very Rare
Severe
Alopecia
Bradycardia
Chest pain
Conjunctivitis
Diplopia
Disorder of cornea
Dizziness
Dyspnea
Eyelid edema
Hypertonia
Keratoconjunctivitis
Ocular inflammation
Ocular itching
Pharyngitis
Renal colic
Urticaria

Less Severe
Iritis
More information
Contraindicated
Brimonidine (Ophthalmic)
1 Day – 2 Years
Reports of apnea, respiratory depression, bradycardia, hypotension, somnolence. Contraindicated age < 2 years.

Severe Precaution
None

Management or Monitoring Precaution
Brimonidine Tartrate
2 Years – 7 Years
Increased somnolence, decreased alertness observed age 2-7 years.
Brinzolamide
1 Day – 5 Years
Reduced efficacy observed in ages < 5 years.
Brimonidine
Severity Level: B
Additional Notes:

Brinzolamide
Severity Level: C
Additional Notes:

More information
Contraindicated
None

Precaution Exists
Brimonidine
GeneralExcretion PotentialEffect on InfantNotes
Evaluate use carefullyUnknownNot known; no or inclusive dataInsufficient human data available; excreted in animal studies
Brinzolamide
GeneralExcretion PotentialEffect on InfantNotes
Evaluate use carefullyUnknownNot known; no or inclusive dataInsufficient data available

No Known Risk
None
More information
No precaution information has been provided for this patient type.
Ocular hypertension
H40.05Ocular hypertension
H40.051Ocular hypertension, right eye
H40.052Ocular hypertension, left eye
H40.053Ocular hypertension, bilateral
H40.059Ocular hypertension, unspecified eye
Open angle glaucoma
H40.1Open-angle glaucoma
H40.10Unspecified open-angle glaucoma
H40.10x0Unspecified open-angle glaucoma, stage unspecified
H40.10x1Unspecified open-angle glaucoma, mild stage
H40.10x2Unspecified open-angle glaucoma, moderate stage
H40.10x3Unspecified open-angle glaucoma, severe stage
H40.10x4Unspecified open-angle glaucoma, indeterminate stage
H40.11Primary open-angle glaucoma
H40.11x0Primary open-angle glaucoma, stage unspecified
H40.11x1Primary open-angle glaucoma, mild stage
H40.11x2Primary open-angle glaucoma, moderate stage
H40.11x3Primary open-angle glaucoma, severe stage
H40.11x4Primary open-angle glaucoma, indeterminate stage
H40.12Low-tension glaucoma
H40.121Low-tension glaucoma, right eye
H40.1210Low-tension glaucoma, right eye, stage unspecified
H40.1211Low-tension glaucoma, right eye, mild stage
H40.1212Low-tension glaucoma, right eye, moderate stage
H40.1213Low-tension glaucoma, right eye, severe stage
H40.1214Low-tension glaucoma, right eye, indeterminate stage
H40.122Low-tension glaucoma, left eye
H40.1220Low-tension glaucoma, left eye, stage unspecified
H40.1221Low-tension glaucoma, left eye, mild stage
H40.1222Low-tension glaucoma, left eye, moderate stage
H40.1223Low-tension glaucoma, left eye, severe stage
H40.1224Low-tension glaucoma, left eye, indeterminate stage
H40.123Low-tension glaucoma, bilateral
H40.1230Low-tension glaucoma, bilateral, stage unspecified
H40.1231Low-tension glaucoma, bilateral, mild stage
H40.1232Low-tension glaucoma, bilateral, moderate stage
H40.1233Low-tension glaucoma, bilateral, severe stage
H40.1234Low-tension glaucoma, bilateral, indeterminate stage
H40.129Low-tension glaucoma, unspecified eye
H40.1290Low-tension glaucoma, unspecified eye, stage unspecified
H40.1291Low-tension glaucoma, unspecified eye, mild stage
H40.1292Low-tension glaucoma, unspecified eye, moderate stage
H40.1293Low-tension glaucoma, unspecified eye, severe stage
H40.1294Low-tension glaucoma, unspecified eye, indeterminate stage
H40.13Pigmentary glaucoma
H40.131Pigmentary glaucoma, right eye
H40.1310Pigmentary glaucoma, right eye, stage unspecified
H40.1311Pigmentary glaucoma, right eye, mild stage
H40.1312Pigmentary glaucoma, right eye, moderate stage
H40.1313Pigmentary glaucoma, right eye, severe stage
H40.1314Pigmentary glaucoma, right eye, indeterminate stage
H40.132Pigmentary glaucoma, left eye
H40.1320Pigmentary glaucoma, left eye, stage unspecified
H40.1321Pigmentary glaucoma, left eye, mild stage
H40.1322Pigmentary glaucoma, left eye, moderate stage
H40.1323Pigmentary glaucoma, left eye, severe stage
H40.1324Pigmentary glaucoma, left eye, indeterminate stage
H40.133Pigmentary glaucoma, bilateral
H40.1330Pigmentary glaucoma, bilateral, stage unspecified
H40.1331Pigmentary glaucoma, bilateral, mild stage
H40.1332Pigmentary glaucoma, bilateral, moderate stage
H40.1333Pigmentary glaucoma, bilateral, severe stage
H40.1334Pigmentary glaucoma, bilateral, indeterminate stage
H40.139Pigmentary glaucoma, unspecified eye
H40.1390Pigmentary glaucoma, unspecified eye, stage unspecified
H40.1391Pigmentary glaucoma, unspecified eye, mild stage
H40.1392Pigmentary glaucoma, unspecified eye, moderate stage
H40.1393Pigmentary glaucoma, unspecified eye, severe stage
H40.1394Pigmentary glaucoma, unspecified eye, indeterminate stage
H40.14Capsular glaucoma with pseudoexfoliation of lens
H40.141Capsular glaucoma with pseudoexfoliation of lens, right eye
H40.1410Capsular glaucoma with pseudoexfoliation of lens, right eye, stage unspecified
H40.1411Capsular glaucoma with pseudoexfoliation of lens, right eye, mild stage
H40.1412Capsular glaucoma with pseudoexfoliation of lens, right eye, moderate stage
H40.1413Capsular glaucoma with pseudoexfoliation of lens, right eye, severe stage
H40.1414Capsular glaucoma with pseudoexfoliation of lens, right eye, indeterminate stage
H40.142Capsular glaucoma with pseudoexfoliation of lens, left eye
H40.1420Capsular glaucoma with pseudoexfoliation of lens, left eye, stage unspecified
H40.1421Capsular glaucoma with pseudoexfoliation of lens, left eye, mild stage
H40.1422Capsular glaucoma with pseudoexfoliation of lens, left eye, moderate stage
H40.1423Capsular glaucoma with pseudoexfoliation of lens, left eye, severe stage
H40.1424Capsular glaucoma with pseudoexfoliation of lens, left eye, indeterminate stage
H40.143Capsular glaucoma with pseudoexfoliation of lens, bilateral
H40.1430Capsular glaucoma with pseudoexfoliation of lens, bilateral, stage unspecified
H40.1431Capsular glaucoma with pseudoexfoliation of lens, bilateral, mild stage
H40.1432Capsular glaucoma with pseudoexfoliation of lens, bilateral, moderate stage
H40.1433Capsular glaucoma with pseudoexfoliation of lens, bilateral, severe stage
H40.1434Capsular glaucoma with pseudoexfoliation of lens, bilateral, indeterminate stage
H40.149Capsular glaucoma with pseudoexfoliation of lens, unspecified eye
H40.1490Capsular glaucoma with pseudoexfoliation of lens, unspecified eye, stage unspecified
H40.1491Capsular glaucoma with pseudoexfoliation of lens, unspecified eye, mild stage
H40.1492Capsular glaucoma with pseudoexfoliation of lens, unspecified eye, moderate stage
H40.1493Capsular glaucoma with pseudoexfoliation of lens, unspecified eye, severe stage
H40.1494Capsular glaucoma with pseudoexfoliation of lens, unspecified eye, indeterminate stage
H40.15Residual stage of open-angle glaucoma
H40.151Residual stage of open-angle glaucoma, right eye
H40.152Residual stage of open-angle glaucoma, left eye
H40.153Residual stage of open-angle glaucoma, bilateral
H40.159Residual stage of open-angle glaucoma, unspecified eye
0-9 A-Z
H40.05 Ocular hypertension
H40.051 Ocular hypertension, right eye
H40.052 Ocular hypertension, left eye
H40.053 Ocular hypertension, bilateral
H40.059 Ocular hypertension, unspecified eye
H40.1 Open-angle glaucoma
H40.10 Unspecified open-angle glaucoma
H40.10x0 Unspecified open-angle glaucoma, stage unspecified
H40.10x1 Unspecified open-angle glaucoma, mild stage
H40.10x2 Unspecified open-angle glaucoma, moderate stage
H40.10x3 Unspecified open-angle glaucoma, severe stage
H40.10x4 Unspecified open-angle glaucoma, indeterminate stage
H40.11 Primary open-angle glaucoma
H40.11x0 Primary open-angle glaucoma, stage unspecified
H40.11x1 Primary open-angle glaucoma, mild stage
H40.11x2 Primary open-angle glaucoma, moderate stage
H40.11x3 Primary open-angle glaucoma, severe stage
H40.11x4 Primary open-angle glaucoma, indeterminate stage
H40.12 Low-tension glaucoma
H40.121 Low-tension glaucoma, right eye
H40.1210 Low-tension glaucoma, right eye, stage unspecified
H40.1211 Low-tension glaucoma, right eye, mild stage
H40.1212 Low-tension glaucoma, right eye, moderate stage
H40.1213 Low-tension glaucoma, right eye, severe stage
H40.1214 Low-tension glaucoma, right eye, indeterminate stage
H40.122 Low-tension glaucoma, left eye
H40.1220 Low-tension glaucoma, left eye, stage unspecified
H40.1221 Low-tension glaucoma, left eye, mild stage
H40.1222 Low-tension glaucoma, left eye, moderate stage
H40.1223 Low-tension glaucoma, left eye, severe stage
H40.1224 Low-tension glaucoma, left eye, indeterminate stage
H40.123 Low-tension glaucoma, bilateral
H40.1230 Low-tension glaucoma, bilateral, stage unspecified
H40.1231 Low-tension glaucoma, bilateral, mild stage
H40.1232 Low-tension glaucoma, bilateral, moderate stage
H40.1233 Low-tension glaucoma, bilateral, severe stage
H40.1234 Low-tension glaucoma, bilateral, indeterminate stage
H40.129 Low-tension glaucoma, unspecified eye
H40.1290 Low-tension glaucoma, unspecified eye, stage unspecified
H40.1291 Low-tension glaucoma, unspecified eye, mild stage
H40.1292 Low-tension glaucoma, unspecified eye, moderate stage
H40.1293 Low-tension glaucoma, unspecified eye, severe stage
H40.1294 Low-tension glaucoma, unspecified eye, indeterminate stage
H40.13 Pigmentary glaucoma
H40.131 Pigmentary glaucoma, right eye
H40.1310 Pigmentary glaucoma, right eye, stage unspecified
H40.1311 Pigmentary glaucoma, right eye, mild stage
H40.1312 Pigmentary glaucoma, right eye, moderate stage
H40.1313 Pigmentary glaucoma, right eye, severe stage
H40.1314 Pigmentary glaucoma, right eye, indeterminate stage
H40.132 Pigmentary glaucoma, left eye
H40.1320 Pigmentary glaucoma, left eye, stage unspecified
H40.1321 Pigmentary glaucoma, left eye, mild stage
H40.1322 Pigmentary glaucoma, left eye, moderate stage
H40.1323 Pigmentary glaucoma, left eye, severe stage
H40.1324 Pigmentary glaucoma, left eye, indeterminate stage
H40.133 Pigmentary glaucoma, bilateral
H40.1330 Pigmentary glaucoma, bilateral, stage unspecified
H40.1331 Pigmentary glaucoma, bilateral, mild stage
H40.1332 Pigmentary glaucoma, bilateral, moderate stage
H40.1333 Pigmentary glaucoma, bilateral, severe stage
H40.1334 Pigmentary glaucoma, bilateral, indeterminate stage
H40.139 Pigmentary glaucoma, unspecified eye
H40.1390 Pigmentary glaucoma, unspecified eye, stage unspecified
H40.1391 Pigmentary glaucoma, unspecified eye, mild stage
H40.1392 Pigmentary glaucoma, unspecified eye, moderate stage
H40.1393 Pigmentary glaucoma, unspecified eye, severe stage
H40.1394 Pigmentary glaucoma, unspecified eye, indeterminate stage
H40.14 Capsular glaucoma with pseudoexfoliation of lens
H40.141 Capsular glaucoma with pseudoexfoliation of lens, right eye
H40.1410 Capsular glaucoma with pseudoexfoliation of lens, right eye, stage unspecified
H40.1411 Capsular glaucoma with pseudoexfoliation of lens, right eye, mild stage
H40.1412 Capsular glaucoma with pseudoexfoliation of lens, right eye, moderate stage
H40.1413 Capsular glaucoma with pseudoexfoliation of lens, right eye, severe stage
H40.1414 Capsular glaucoma with pseudoexfoliation of lens, right eye, indeterminate stage
H40.142 Capsular glaucoma with pseudoexfoliation of lens, left eye
H40.1420 Capsular glaucoma with pseudoexfoliation of lens, left eye, stage unspecified
H40.1421 Capsular glaucoma with pseudoexfoliation of lens, left eye, mild stage
H40.1422 Capsular glaucoma with pseudoexfoliation of lens, left eye, moderate stage
H40.1423 Capsular glaucoma with pseudoexfoliation of lens, left eye, severe stage
H40.1424 Capsular glaucoma with pseudoexfoliation of lens, left eye, indeterminate stage
H40.143 Capsular glaucoma with pseudoexfoliation of lens, bilateral
H40.1430 Capsular glaucoma with pseudoexfoliation of lens, bilateral, stage unspecified
H40.1431 Capsular glaucoma with pseudoexfoliation of lens, bilateral, mild stage
H40.1432 Capsular glaucoma with pseudoexfoliation of lens, bilateral, moderate stage
H40.1433 Capsular glaucoma with pseudoexfoliation of lens, bilateral, severe stage
H40.1434 Capsular glaucoma with pseudoexfoliation of lens, bilateral, indeterminate stage
H40.149 Capsular glaucoma with pseudoexfoliation of lens, unspecified eye
H40.1490 Capsular glaucoma with pseudoexfoliation of lens, unspecified eye, stage unspecified
H40.1491 Capsular glaucoma with pseudoexfoliation of lens, unspecified eye, mild stage
H40.1492 Capsular glaucoma with pseudoexfoliation of lens, unspecified eye, moderate stage
H40.1493 Capsular glaucoma with pseudoexfoliation of lens, unspecified eye, severe stage
H40.1494 Capsular glaucoma with pseudoexfoliation of lens, unspecified eye, indeterminate stage
H40.15 Residual stage of open-angle glaucoma
H40.151 Residual stage of open-angle glaucoma, right eye
H40.152 Residual stage of open-angle glaucoma, left eye
H40.153 Residual stage of open-angle glaucoma, bilateral
H40.159 Residual stage of open-angle glaucoma, unspecified eye

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Diagnosis codes are provided for reference only. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatement.