Simbrinza (brinzolamide/brimonidine tartrate) — ALCON LABS.

Open angle glaucoma
Ocular hypertension
1 %-0.2 % eye drops,suspension
Instill 1 drop into affected eye(s) by ophthalmic route 3 times per day

Ocular hypertension
Dosage Type: Suspension, drops(final dosage form)(ml)
Instill 1 drop into both eyes by ophthalmic route 3 times per day
Instill 1 drop into left eye by ophthalmic route 3 times per day
Instill 1 drop into right eye by ophthalmic route 3 times per day
Instill 1 drop into affected eye(s) by ophthalmic route 3 times per day

Open angle glaucoma
Instill 1 drop into both eyes by ophthalmic route 3 times per day
Instill 1 drop into left eye by ophthalmic route 3 times per day
Instill 1 drop into right eye by ophthalmic route 3 times per day
Instill 1 drop into affected eye(s) by ophthalmic route 3 times per day
Severe Warnings
Severe cardiovascular disease
Severe renal disease
Contraindicated
None
Moderate Warnings
Buerger's disease
Cerebrovascular disorder
Depression
Orthostatic hypotension
Raynaud's phenomenon
Less Frequent
Severe
Allergic dermatitis
Blepharitis
Blurred vision
Chemosis
Conjunctival hemorrhage
Corneal erosion
Depression
Dizziness
Erythema
Eyelid edema
Fainting
Gastrointestinal irritation
Headache disorder
Hypertension
Keratitis
Mucopurulent conjunctivitis
Myalgia
Nasal congestion
Nausea
Ocular discharge
Ocular discomfort
Ocular pain
Rhinitis
Sneezing
Visual changes
Vomiting

Less Severe
Anxiety
Conjunctival blanching
Corneal staining
Dry eye
Dysgeusia
Insomnia
Muscle weakness
Ocular crusting
Ocular discomfort
Palpitations
Photophobia
Rhinitis
More Frequent
Severe
Allergic reactions
Conjunctival hyperemia
Follicular conjunctivitis
Headache disorder
Ocular itching
Ocular redness

Less Severe
Allergic conjunctivitis
Blurred vision
Drowsy
Dysgeusia
Eye tearing
Fatigue
Ocular irritation
Xerostomia
Rare / Very Rare
Severe
Allergic reactions
Alopecia
Bradycardia
Chest pain
Conjunctivitis
Diplopia
Disorder of cornea
Dizziness
Dyspnea
Eyelid edema
Hypertonia
Keratoconjunctivitis
Ocular inflammation
Ocular itching
Pharyngitis
Renal colic
Urticaria

Less Severe
Iritis
More information
Contraindicated
Brimonidine (Ophthalmic)
1 Day – 2 Years
Reports of apnea, respiratory depression, bradycardia, hypotension, somnolence. Contraindicated age < 2 years.

Severe Precaution
None

Management or Monitoring Precaution
Brimonidine Tartrate
2 Years – 7 Years
Increased somnolence, decreased alertness observed age 2-7 years.
Brinzolamide
1 Day – 5 Years
Reduced efficacy observed in ages < 5 years.
Brimonidine
Severity Level: B
Additional Notes:

Brinzolamide
Severity Level: C
Additional Notes:

More information
Contraindicated
None

Precaution Exists
Brimonidine
GeneralExcretion PotentialEffect on InfantNotes
Evaluate use carefullyUnknownNot known; no or inclusive dataInsufficient human data available; excreted in animal studies
Brinzolamide
GeneralExcretion PotentialEffect on InfantNotes
Evaluate use carefullyUnknownNot known; no or inclusive dataInsufficient data available

No Known Risk
None
More information
No precaution information has been provided for this patient type.
Ocular hypertension
365Glaucoma
365.0Borderline glaucoma
365.00Preglaucoma not otherwise specified
365.01Open angle with low risk and borderline findings
365.02Anatomical narrow angle
365.03Steroid responders- manifesting increased intraocular pressure
365.04Ocular hypertension
365.05Open angle with borderline findings, high risk
365.06Primary angle closure without glaucoma damage
365.3Steroid-induced glaucoma
365.31Glaucomatous stage of steroid-induced glaucoma
365.32Residual stage of steroid-induced glaucoma
365.44Glaucoma with systemic syndromes
365.62Glaucoma with ocular inflammation
365.63Glaucoma with vascular disorders
365.64Glaucoma with tumors or cysts
365.65Glaucoma with ocular trauma
365.70Unspecified glaucoma stage
365.71Mild stage glaucoma
365.72Moderate stage glaucoma
365.73Severe stage glaucoma
365.74Indeterminate stage glaucoma
365.83Aqueous misdirection
Open angle glaucoma
365Glaucoma
365.01Open angle with low risk and borderline findings
365.05Open angle with borderline findings, high risk
365.1Open-angle glaucoma
365.10Open-angle glaucoma not otherwise specified
365.11Primary open-angle glaucoma
365.15Residual open-angle glaucoma
365.70Unspecified glaucoma stage
365.71Mild stage glaucoma
365.72Moderate stage glaucoma
365.73Severe stage glaucoma
365.74Indeterminate stage glaucoma
0-9 A-Z
365 Glaucoma
365 Glaucoma
365.0 Borderline glaucoma
365.00 Preglaucoma not otherwise specified
365.01 Open angle with low risk and borderline findings
365.01 Open angle with low risk and borderline findings
365.02 Anatomical narrow angle
365.03 Steroid responders- manifesting increased intraocular pressure
365.04 Ocular hypertension
365.05 Open angle with borderline findings, high risk
365.05 Open angle with borderline findings, high risk
365.06 Primary angle closure without glaucoma damage
365.1 Open-angle glaucoma
365.10 Open-angle glaucoma not otherwise specified
365.11 Primary open-angle glaucoma
365.15 Residual open-angle glaucoma
365.3 Steroid-induced glaucoma
365.31 Glaucomatous stage of steroid-induced glaucoma
365.32 Residual stage of steroid-induced glaucoma
365.44 Glaucoma with systemic syndromes
365.62 Glaucoma with ocular inflammation
365.63 Glaucoma with vascular disorders
365.64 Glaucoma with tumors or cysts
365.65 Glaucoma with ocular trauma
365.70 Unspecified glaucoma stage
365.70 Unspecified glaucoma stage
365.71 Mild stage glaucoma
365.71 Mild stage glaucoma
365.72 Moderate stage glaucoma
365.72 Moderate stage glaucoma
365.73 Severe stage glaucoma
365.73 Severe stage glaucoma
365.74 Indeterminate stage glaucoma
365.74 Indeterminate stage glaucoma
365.83 Aqueous misdirection

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Diagnosis codes are provided for reference only. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatement.